152 research outputs found
A NECESSARY AND SUFFICIENT CONDITION FOR A KERNEL TO BE A WEAK POTENTIAL KERNEL OF A RECURRENT MARKOV CHAIN
Some properties of Markov processes associated with time dependent Dirichlet forms (Dedicated to Professor Takesi Watanabe on his 60th birthday)
ROCK-I regulates closure of the eyelids and ventral body wall by inducing assembly of actomyosin bundles
Rho-associated kinase (ROCK) I mediates signaling from Rho to the actin cytoskeleton. To investigate the in vivo functions of ROCK-I, we generated ROCK-I–deficient mice. Loss of ROCK-I resulted in failure of eyelid closure and closure of the ventral body wall, which gave rise to the eyes open at birth and omphalocele phenotypes in neonates. Most ROCK-I−/− mice died soon after birth as a result of cannibalization of the omphalocele by the mother. Actin cables that encircle the eye in the epithelial cells of the eyelid were disorganized and accumulation of filamentous actin at the umbilical ring was impaired, with loss of phosphorylation of the myosin regulatory light chain (MLC) at both sites, in ROCK-I−/− embryos. Stress fiber formation and MLC phosphorylation induced by EGF were also attenuated in primary keratinocytes from ROCK-I−/− mice. These results suggest that ROCK-I regulates closure of the eyelids and ventral body wall through organization of actomyosin bundles
ジクウ キョクメン デ トクイ ニ ヘンドウ スル カクサン カテイ ノ ケンキュウ
本研究の目的は、時間的に一様でない場合の拡散過程の挙動、特に時間と共に変動する変動する領域への到達可能性について調べる事及び到達した後の境界上での挙動について調べる事であった
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