Датчик угла поворота генераторного типа с элементом на поверхностных акустических волнах

Разработан интеллектуализированный датчик угла поворота с акустоэлектронным элементом оригинальной конструкции, выполняющим роль линии задержки.Представлено результати розробки інтелектуалізованого датчика кута повороту з елементом на поверхневих акустичних хвилях (ПАХ). Описано структурну схему сенсора генераторного типу, в якому елемент на ПАХ грає роль відповідної лінії затримки. Представлено основні характеристики датчика, показано область його застосування.·The results of intellectualized angle of rotation sensor with an element on the surface acoustic waves (SAW) development are presented. The generating type sensor block diagram, in which the element on SAW plays a role of the appropriate line of a delay is described. The sensor basic characteristics are given and the area of its application are shown

DOCK2 is involved in the host genetics and biology of severe COVID-19

「コロナ制圧タスクフォース」COVID-19疾患感受性遺伝子DOCK2の重症化機序を解明 --アジア最大のバイオレポジトリーでCOVID-19の治療標的を発見--. 京都大学プレスリリース. 2022-08-10.Identifying the host genetic factors underlying severe COVID-19 is an emerging challenge. Here we conducted a genome-wide association study (GWAS) involving 2, 393 cases of COVID-19 in a cohort of Japanese individuals collected during the initial waves of the pandemic, with 3, 289 unaffected controls. We identified a variant on chromosome 5 at 5q35 (rs60200309-A), close to the dedicator of cytokinesis 2 gene (DOCK2), which was associated with severe COVID-19 in patients less than 65 years of age. This risk allele was prevalent in East Asian individuals but rare in Europeans, highlighting the value of genome-wide association studies in non-European populations. RNA-sequencing analysis of 473 bulk peripheral blood samples identified decreased expression of DOCK2 associated with the risk allele in these younger patients. DOCK2 expression was suppressed in patients with severe cases of COVID-19. Single-cell RNA-sequencing analysis (n = 61 individuals) identified cell-type-specific downregulation of DOCK2 and a COVID-19-specific decreasing effect of the risk allele on DOCK2 expression in non-classical monocytes. Immunohistochemistry of lung specimens from patients with severe COVID-19 pneumonia showed suppressed DOCK2 expression. Moreover, inhibition of DOCK2 function with CPYPP increased the severity of pneumonia in a Syrian hamster model of SARS-CoV-2 infection, characterized by weight loss, lung oedema, enhanced viral loads, impaired macrophage recruitment and dysregulated type I interferon responses. We conclude that DOCK2 has an important role in the host immune response to SARS-CoV-2 infection and the development of severe COVID-19, and could be further explored as a potential biomarker and/or therapeutic target

The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

「コロナ制圧タスクフォース」COVID-19患者由来の血液細胞における遺伝子発現の網羅的解析 --重症度に応じた遺伝子発現の変化には、ヒトゲノム配列の個人差が影響する--. 京都大学プレスリリース. 2022-08-23.Coronavirus disease 2019 (COVID-19) is a recently-emerged infectious disease that has caused millions of deaths, where comprehensive understanding of disease mechanisms is still unestablished. In particular, studies of gene expression dynamics and regulation landscape in COVID-19 infected individuals are limited. Here, we report on a thorough analysis of whole blood RNA-seq data from 465 genotyped samples from the Japan COVID-19 Task Force, including 359 severe and 106 non-severe COVID-19 cases. We discover 1169 putative causal expression quantitative trait loci (eQTLs) including 34 possible colocalizations with biobank fine-mapping results of hematopoietic traits in a Japanese population, 1549 putative causal splice QTLs (sQTLs; e.g. two independent sQTLs at TOR1AIP1), as well as biologically interpretable trans-eQTL examples (e.g., REST and STING1), all fine-mapped at single variant resolution. We perform differential gene expression analysis to elucidate 198 genes with increased expression in severe COVID-19 cases and enriched for innate immune-related functions. Finally, we evaluate the limited but non-zero effect of COVID-19 phenotype on eQTL discovery, and highlight the presence of COVID-19 severity-interaction eQTLs (ieQTLs; e.g., CLEC4C and MYBL2). Our study provides a comprehensive catalog of whole blood regulatory variants in Japanese, as well as a reference for transcriptional landscapes in response to COVID-19 infection

Azimuthal Anisotropy of the Megaregolith at the Apollo 14 Landing Site

The characterization of the megaregolith on the Moon has been investigated in various ways including analysis of lunar meteorites, remote sensing of mineralogy and gravity, and deriving a seismic velocity profile. In this study, we propose a method for analyzing azimuthal anisotropy of the megaregolith. We call this method deep-moonquake seismic interferometry applied to S-wave coda (DMSI-S). DMSI-S can turn the records of deep moonquakes into recordings from virtual active sources. The retrieved virtual sources coincide with the station positions, and thus, we obtain virtual zero-offset (pulse-echo) measurements. DMSI-S is applied to seven clusters of deep moonquakes recorded at the Apollo 14 landing site, resulting in virtual zero-offset measurements at the Apollo station 14. We use the S-wave recordings retrieved from DMSI-S to analyze azimuthal anisotropy. We find weak anisotropy at the layer where the megaregolith is assumed to be present. We interpret our result to show that the megaregolith at this site is characterized by a layer (or layers) of impact material, following the Imbrium impact, with internal alignment of the crushed material

Azimuthal Anisotropy of the Megaregolith at the Apollo 14 Landing Site

The characterization of the megaregolith on the Moon has been investigated in various ways including analysis of lunar meteorites, remote sensing of mineralogy and gravity, and deriving a seismic velocity profile. In this study, we propose a method for analyzing azimuthal anisotropy of the megaregolith. We call this method deep-moonquake seismic interferometry applied to S-wave coda (DMSI-S). DMSI-S can turn the records of deep moonquakes into recordings from virtual active sources. The retrieved virtual sources coincide with the station positions, and thus, we obtain virtual zero-offset (pulse-echo) measurements. DMSI-S is applied to seven clusters of deep moonquakes recorded at the Apollo 14 landing site, resulting in virtual zero-offset measurements at the Apollo station 14. We use the S-wave recordings retrieved from DMSI-S to analyze azimuthal anisotropy. We find weak anisotropy at the layer where the megaregolith is assumed to be present. We interpret our result to show that the megaregolith at this site is characterized by a layer (or layers) of impact material, following the Imbrium impact, with internal alignment of the crushed material