4 research outputs found
Protective effect of <i style="">Ocimum sanctum </i>L after high-dose <sup>131</sup>iodine exposure in mice:An <i style="">in vivo</i> study
647-652Radioprotective
effect of aqueous extract of Ocimum
sanctum (40 mg/kg body weight, for 15 days) in mice exposed to high-doses (3.7 MBq) of oral 131iodine
was investigated by studying the organ weights, lipid peroxidation and
antioxidant defense enzymes in various target organs like liver, kidneys,
salivary glands and stomach at 24 hr after exposure in adult Swiss mice. The
mean weight of the salivary glands showed significant increase after 131iodine
administration. 131iodine exposure significantly increased lipid
peroxidation in kidneys and salivary glands in comparison to control animals. Pretreatment
with O. sanctum in radioiodine
exposed group showed significant reduction in lipid peroxidation in both
kidneys and salivary glands. In liver, reduced glutathione (GSH) levels showed
significant reduction after radioiodine exposure while pretreatment with O. sanctum exhibited less depletion in
GSH level even after 131iodine exposure. However, no such changes
were observed in stomach. The results indicate the possibility of using aqueous
extract of O. sanctum for
ameliorating 131Iodine induced damage to the salivary glands
Effect of <i>Ocimum sanctum</i>, turmeric extract and vitamin E supplementation on the salivary gland and bone marrow of radioiodine exposed mice
566-571Significant increase in the salivary gland
weight was observed after exposure to single therapeutic dose of 3.7 MBq
of 131I in mice. Pre-supplementation of antioxidants, O. sanctum
leaf extract, turmeric extract and vitamin E for 15 days before 131I
exposure demonstrated significant reduction in the salivary gland weight. No
major histopathological changes were observed in the salivary gland of
experimental animals at 24 h of exposure. Micronuclei index in the bone marrow
of polychromatic (PCEs) and normochromatic erythrocytes (NCEs) remained
unchanged in all the experimental groups. However, PCE/NCE ratio in the bone
marrow decreased significantly in all the 131I exposed animals
irrespective of antioxidant supplementation status. The normalization of
salivary gland weight by antioxidant pre-supplementation in radioiodine exposed
mice is suggestive of the possible ameliorating effect of antioxidants on the
salivary gland weight recommending further detailed studies regarding the
functional aspect of the salivary gland in higher animals