Biocompatible dendrimer for the solubility enhancement and sustained release of piroxicam

Piroxicam (PRM) a nonsteroidal anti-inflammatory medication is an oxicam-class used orally to treat gout, arthritis, and other inflammatory diseases. However, its poor aqueous solubility and bioavailability has hampered further clinical applications in health industries. This work emphasize on development of four types of functionalised biocompatible dendrimer with generation 0 and 1and examine its solubility, drug release and antibacterial activity. The maximum solubility enhancement of PRM up to 48 folds has been achieved by PAMAM (G1)-CH3 at a concentration of 9.9×10-4 M. The in vitro release gets sustained up to 450 mins for releasing 90% of drug from PAMAM (G1)-COCH3 compared to its parent dendrimer which is 120 min. The anti-bacterial studies reflected that when dendrimers are used as drug carriers, the inherent property of drug is not disturbed, instead the activity has been increased. The activity interms of zone of inhibition results in 1.5-2.0 folds increase and it is more pronounced in the case of B. subtilis rather than E.coli. This observation indicates evidence that dendrimer and their derivatives are promising candidates for drug solubility enhancer and effective delivery of drugs with drastic reduction in side effect and improved efficiency

AN ASSESSMENT OF VARIOUS NANOADDITIVES AND TRIBO-CORROSION WITH WASTE COOKING BIODIESEL FUELED IN A DIESEL ENGINE

The waste cooking biodiesel's steady-state coefficient of friction rate of fuel blends are B90 (18.2%), B60 (7.2%), B20 (16.72%), B10 (30.8%), and diesel (38.77%) higher compared with B40 fuel blend and wear scar diameter of the fuel blends from B40 to B100 had a minimal range of 0.5mm. The flash temperature parameter results higher from B40 to B100 fuel blends, and the corrosion rate was minimal for B40 and B50 fuel blends. Afterward, the fuel blend B40 (40% WCO+60% Diesel fuel) was chosen as fuel, along with Cerium (25ppm), Zinc (25ppm), and Titanium nanoparticles (25ppm) were selected as fuel additives. The B40+D60+Titanium (25ppm) blend resulted in improved BTE and 3.83% lowered BSEC comparison with diesel fuel. Then the fuel blend, B40+D80+Titanium (25ppm), resulted in 2.08% reduced HC, 36.36% CO, and 16.25% smoke emissions, along with marginally 8.5% higher NOx emissions comparison with diesel fuel. Also, the fuel blend, B40+D80+Titanium (25ppm) combustions characteristics are the equivalent trend of cylinder pressure (58.82 bar) and HRR (66.65 J/deg CA) related to diesel fuel at peak load.The accepted manuscript in pdf format is listed with the files at the bottom of this page. The presentation of the authors' names and (or) special characters in the title of the manuscript may differ slightly between what is listed on this page and what is listed in the pdf file of the accepted manuscript; that in the pdf file of the accepted manuscript is what was submitted by the author

POWER QUALITY IMPROVEMENT BY VOLTAGE CONTROL USING DSTATCOM IN MATLAB

ABSTRACT This paper proposes a new topology by Distribution Static Compensator using Matlab. This proposed method of power quality improvement achieves UPF which is not possible in previous methods. Maximum UPF is maintained, while regulating voltage at the load terminal, during fluctuation of load. Dstatcom solves Power quality issues by achieving PF correction, harmonic elimination, load balancing, and voltage regulation based on the load requirement

Solar Photovoltaic Option for Meeting Power Demand at Pondicherry Engineering College

ABSTRACT: The depletion of fossil fuel resources on a worldwide basis has necessitated an urgent search for alternative energy sources to meet up the present day demands. Solar energy is clean, inexhaustible and environmentfriendly potential resource among renewable energy options. But neither a standalone solar photovoltaic system nor a wind energy system can provide a continuous supply of energy due to seasonal and periodic variations. Therefore, in order to satisfy the load demand, grid connected energy systems are now being implemented that combine solar and conventional conversion units. Solar photovoltaic option for meeting power demand at Pondicherry engineering college is fully theoretical based project. The main objective of this project are Meteorological data for the site ,Load forecasting at Pondicherry engineering college, Component selection ,Design layout of solar photovoltaic plant ,Testing and analysis of system design by using PVSYST software .Finally obtained electricity consumption by load forecasting technique can be validated by using PVSYST software. KEYWORDS: grid connected, solar photovoltaic system, Meteorological data for the site, load forecasting, design layout, testing and analysis using PVSYST software I.INTRODUCTION Energy plays a pivotal role in our daily activities. The degree of development and civilization of a country is measured by the amount of utilization of energy by human beings. Energy demand is increasing day by day due to increase in population, urbanization and industrialization. The world's fossil fuel viz., coal, petroleum and natural gas will thus deplete in few hundred years. The rate of energy consumption increasing, supply is depleting resulting in inflation and energy shortage. This is called energy crisis. Hence alternative or renewable sources of energy have to be developed to meet future energy requirement. WE PREFER GRID CONNECTED PV SYSTEM Because as day by day the demand of electricity is increased and that much demand cannot be meeting up by the conventional power plants. And also these plants create pollution. So if we go for the renewable energy it will be better but throughout the year the generation of all renewable energy power plants. Grid tied PV system is more reliable than other PV system. No use of battery reduces its capital cost so we go for the grid connected topology. If generated solar energy is integrated to the conventional grid, it can supply the demand from morning to afternoon (total 6 hours mainly in sunny days) that is the particular time range when the SPV system can fed to grid. As no battery backup is there, that means the utility will continue supply to the rest of the time period. Grid-connected systems have demonstrated an advantage in natural disasters by providing emergency power capabilities when utility power was interrupted. Although PV power is generally more expensive than utility-provided power, the use of grid connected systems is increasing. II. METHODOLOGY OF THIS PROJECT The methodologies of the projects are as follows Meteorological Data for the site Load calculation at Pondicherry engineering college Selection of components System sizing and specificatio

Biocompatible dendrimer for the solubility enhancement and sustained release of piroxicam

647-657Piroxicam (PRM) a nonsteroidal anti-inflammatory medication is an oxicam-class used orally to treat gout, arthritis, and other inflammatory diseases. However, its poor aqueous solubility and bioavailability has hampered further clinical applications in health industries. This work emphasize on development of four types of functionalised biocompatible dendrimer with generation 0 and 1and examine its solubility, drug release and antibacterial activity. The maximum solubility enhancement of PRM up to 48 folds has been achieved by PAMAM (G1)-CH3 at a concentration of 9.9×10-4 M. The in vitro release gets sustained up to 450 mins for releasing 90% of drug from PAMAM (G1)-COCH3 compared to its parent dendrimer which is 120 min. The anti-bacterial studies reflected that when dendrimers are used as drug carriers, the inherent property of drug is not disturbed, instead the activity has been increased. The activity interms of zone of inhibition results in 1.5-2.0 folds increase and it is more pronounced in the case of B. subtilis rather than E.coli. This observation indicates evidence that dendrimer and their derivatives are promising candidates for drug solubility enhancer and effective delivery of drugs with drastic reduction in side effect and improved efficiency

Genotoxicity evaluation of medical devices: A regulatory perspective

This review critically evaluates our current regulatory understanding of genotoxicity testing and risk assessment of medical devices. Genotoxicity risk assessment of these devices begins with the evaluation of materials of construction, manufacturing additives and all residual materials for potential to induce DNA damage. This is followed by extractable and/or leachable (E&L) studies to understand the worst case and/or clinical exposures, coupled with risk assessment of extractables or leachables. The TTC (Threshold of Toxicological Concern) approach is used to define acceptable levels of genotoxic chemicals, when identified. Where appropriate, in silico predictions may be used to evaluate the genotoxic potentials of identifiable chemicals with limited toxicological data and above the levels defined by TTC. Devices that could not be supported by E&L studies are evaluated by in vitro genotoxicity studies conducted in accordance with ISO10993-3 and 33. Certain endpoints such as ‘site of contact genotoxicity’ that are specific for certain classes of medical devices are currently not addressed in the current standards. The review also illustrates the potential uses of recent advances to achieve the goal of robust genotoxicity assessment of medical devices which are being increasingly used for health benefits. The review also highlights the gaps for genotoxicity risk assessment of medical devices and suggests possible approaches to address them taking into consideration the recent advances in genotoxicity testing including their potential uses in biocompatibility assessment