Devil\u27s Game: The Civil War Intrigues of Charles A. Dunham

Termite of historical truth Author deduces the motives of the war\u27s biggest con artist It was, I believe, Sir Winston Churchill who pronounced the American Civil War the last war between gentlemen. There is truth in that. Many officers, North and South, were professionals who had...

Mid-Atlantic Orchard Monitoring Guide (NRAES 75)

This 361 page publication (NRAES-75) was originally published by the Northeast Regional Agricultural Engineering Service (NRAES, later known as the Natural Resource, Agriculture, and Engineering Service), a multi-university program in the Northeast US disbanded in 2011. Plant and Life Sciences Publishing (PALS) was subsequently formed to manage the NRAES catalog. Ceasing operations in 2018, PALS was a program of the Department of Horticulture in the College of Agriculture and Life Sciences (CALS) at Cornell University. PALS assisted university faculty in publishing, marketing and distributing books for small farmers, gardeners, land owners, workshops, college courses, and consumers.The tree fruit industry represents a complex agroecosystem that requires numerous management decisions in diverse areas in order to maintain profitability in an increasingly competitive global market. Wise decisions begin with a thorough knowledge of the various production components and an awareness of their status in the orchard. Monitoring is the tool for acquiring periodic information about the orchard situation so that timely decisions can be made and action can be taken. It seemed appropriate to assemble the collective expertise of numerous individuals into a regional guide for orchard monitoring because there are more similarities than differences in the production of tree fruits in the mid-Atlantic region. Our goal was to develop a user-friendly, multi-disciplinary guide for use by fruit growers, consultants, chemical field representatives, and research and extension personnel. This Mid-Atlantic Orchard Monitoring Guide is authored by 37 fruit researchers and extension specialists from land grant universities in Maryland, New Jersey, Pennsylvania, Virginia, and West Virginia, as well as researchers from the Pennsylvania Department of Agriculture and the United States Department of Agriculture (USDA). Authors for the various sections of the guide were selected by discipline chairs in entomology, plant pathology/ nematology and horticulture. Discipline chairs were responsible for collecting and assembling written material and photos from the authors for submission to the editor

Functional Analysis and Fine Mapping of the 9p22.2 Ovarian Cancer Susceptibility Locus

Genome-wide association studies have identified 40 ovarian cancer risk loci. However, the mechanisms underlying these associations remain elusive. In this study, we conducted a two-pronged approach to identify candidate causal SNPs and assess underlying biological mechanisms at chromosome 9p22.2, the first and most statistically significant associated locus for ovarian cancer susceptibility. Three transcriptional regulatory elements with allele-specific effects and a scaffold/matrix attachment region were characterized and, through physical DNA interactions, BNC2 was established as the most likely target gene. We determined the consensus binding sequence for BNC2 in vitro, verified its enrichment in BNC2 ChIP-seq regions, and validated a set of its downstream target genes. Fine-mapping by dense regional genotyping in over 15,000 ovarian cancer cases and 30,000 controls identified SNPs in the scaffold/matrix attachment region as among the most likely causal variants. This study reveals a comprehensive regulatory landscape at 9p22.2 and proposes a likely mechanism of susceptibility to ovarian cancer. SIGNIFICANCE: Mapping the 9p22.2 ovarian cancer risk locus identifies BNC2 as an ovarian cancer risk gene.See related commentary by Choi and Brown, p. 439.status: publishe