Using NASA-TLX to evaluate the flight deck design in Design Phase of Aircraft

AbstractSafety is the most important consideration in civil aviation, and human factors directly influence the safety of an aircraft. This paper focused on implementing the human factors by using improved NASA-TLX to enhance the safety of aircraft in the design phase

Pseudorandomness Analysis of the Lai-Massey Scheme

At Asiacrypt’99, Vaudenay modified the structure in the IDEA cipher to a new scheme, which they called as the Lai-Massey scheme. It is proved that 3-round Lai-Massey scheme is sufficient for pseudorandomness and 4-round Lai-Massey scheme is sufficient for strong pseudorandomness. But the author didn’t point out whether three rounds and four rounds are necessary for the pseudorandomness and strong pseudorandomness of the Lai-Massey Scheme. In this paper we find a two round pseudorandomness distinguisher and a three-round strong pseudorandomness distinguisher, thus prove that three rounds is necessary for the pseudorandomness and four rounds is necessary for the strong pseudorandomness

Toll-like receptor-mediated innate immunity against herpesviridae infection: a current perspective on viral infection signaling pathways

BACKGROUND: In the past decades, researchers have demonstrated the critical role of Toll-like receptors (TLRs) in the innate immune system. They recognize viral components and trigger immune signal cascades to subsequently promote the activation of the immune system. MAIN BODY: Herpesviridae family members trigger TLRs to elicit cytokines in the process of infection to activate antiviral innate immune responses in host cells. This review aims to clarify the role of TLRs in the innate immunity defense against herpesviridae, and systematically describes the processes of TLR actions and herpesviridae recognition as well as the signal transduction pathways involved. CONCLUSIONS: Future studies of the interactions between TLRs and herpesviridae infections, especially the subsequent signaling pathways, will not only contribute to the planning of effective antiviral therapies but also provide new molecular targets for the development of antiviral drugs

Metabolic and senescence characteristics associated with the immune microenvironment in ovarian cancer

Ovarian cancer is a highly malignant gynecological cancer influenced by the immune microenvironment, metabolic reprogramming, and cellular senescence. This review provides a comprehensive overview of these characteristics. Metabolic reprogramming affects immune cell function and tumor growth signals. Cellular senescence in immune and tumor cells impacts anti-tumor responses and therapy resistance. Targeting immune cell metabolism and inducing tumor cell senescence offer potential therapeutic strategies. However, challenges remain in identifying specific targets and biomarkers. Understanding the interplay of these characteristics can lead to innovative therapeutic approaches. Further research is needed to elucidate mechanisms, validate strategies, and improve patient outcomes in ovarian cancer

(Li0.84Fe0.16)OHFe0.98Se superconductor: Ion-exchange synthesis of large single crystal and highly two-dimensional electron properties

A large and high-quality single crystal (Li0.84Fe0.16)OHFe0.98Se, the optimal superconductor of newly reported (Li1-xFex)OHFe1-ySe system, has been successfully synthesized via a hydrothermal ion-exchange technique. The superconducting transition temperature (Tc) of 42 K is determined by magnetic susceptibility and electric resistivity measurements, and the zero-temperature upper critical magnetic fields are evaluated as 79 and 313 Tesla for the field along the c-axis and the ab-plane, respectively. The ratio of out-of-plane to in-plane electric resistivity,\r{ho}c/\r{ho}ab, is found to increases with decreasing temperature and to reach a high value of 2500 at 50 K, with an evident kink occurring at a characteristic temperature T*=120 K. The negative in-plane Hall coefficient indicates that electron carriers dominate in the charge transport, and the hole contribution is significantly reduced as the temperature is lowered to approach T*. From T* down to Tc, we observe the linear temperature dependences of the in-plane electric resistivity and the magnetic susceptibility for the FeSe layers. Our findings thus reveal that the normal state of (Li0.84Fe0.16)OHFe0.98Se becomes highly two-dimensional and anomalous prior to the superconducting transition, providing a new insight into the mechanism of high-Tc superconductivity.Comment: 11 pages, 4 figures, supplementary information is not uploade

Pseudorandomness analysis of the (extended) Lai–Massey scheme

In this paper we find that the two-round (extended) Lai–Massey scheme is not pseudorandom and three-round (extended) Lai–Massey scheme is not strong pseudorandom. Combined with previous work, we prove that three rounds are necessary and sufficient for the pseudorandomness and four rounds are necessary and sufficient for the strong pseudorandomness