2 research outputs found
Accurate and High-Resolution Particle Mass Measurement Using a Peak Filtering Algorithm
Charge
detection quadrupole ion trap mass spectrometry (CD-QIT
MS) is an effective way of achieving the mass analysis of microparticles
with ultrahigh mass. However, its mass accuracy and resolution are
still poor. To enhance the performance of CD-QIT MS, the resolution Rpeak of each peak in the mass spectra resulting
from an individual particle was assessed, and a peak filtering algorithm
that can filter out particle adducts and clusters with a lower Rpeak was proposed. By using this strategy, more
accurate mass information about the analyzed particles could be obtained,
and the mass resolution of CD-QIT MS was improved by nearly 2-fold,
which was demonstrated by using the polystyrene (PS) particle size
standards and red blood cells (RBCs). Benefiting from these advantages
of the peak filtering algorithm, the baseline separation and relative
quantification of 3 and 4 μm PS particles were achieved. To
prove the application value of this algorithm in a biological system,
the mass of yeast cells harvested at different times was measured,
and it was found that the mixed unbudded and budded yeast cells, which
otherwise would not be differentiable, were distinguished and quantified
with the algorithm
Data_Sheet_1_Rescue subthalamic stimulation after unsatisfactory outcome of pallidal stimulation in Parkinson's disease: a case series and review.PDF
BackgroundSubthalamic nucleus (STN) and globus pallidus interna (GPi) are two main structures primarily targeted by deep brain stimulation (DBS) to treat advanced Parkinson's disease (PD). A subset of cases with unsatisfactory outcomes may benefit from rescue DBS surgery targeting another structure, while these patients' characteristics have not been well described and this phenomenon has not been well reviewed.MethodsThis monocentric retrospective study included patients with PD, who underwent rescue STN DBS following an unsatisfactory outcome of the initial bilateral GPi DBS in a retrospective manner. A short review of the current literature was conducted to report the clinical outcome of rescue DBS surgeries.ResultsEight patients were identified, and six of them were included in this study. The rescue STN DBS was performed 19.8 months after the initial GPi DBS. After 8.8 months from the rescue STN DBS, patients showed a significant off-medication improvement by 29.2% in motor symptoms compared to initial GPi DBS. Non-motor symptoms and the health-related quality of life were also significantly improved.ConclusionOur findings suggest that the rescue STN DBS may improve off-medication motor and non-motor symptoms and quality of life in patients with failure of initial GPi DBS. The short review of the current literature showed that the target switching from GPi to STN was mainly due to poor initial outcomes and was performed by target substitution, whereas the switching from STN to GPi was mainly due to a gradual waning of benefits, long-term axial symptoms, dyskinesia, and dystonia and was performed by target addition.</p