Identification of the enterprise financialization motivation on crowding out R&D innovation: evidence from listed companies in China

Enterprise financial asset allocation depends on its motivation, which significantly influences its R&D innovation. In this study, we theoretically analyzed the motivation behind the crowding-out effect of enterprise financialization on R&D innovation and constructed a panel data model to identify enterprise financialization behavior. Furthermore, we analyzed the characteristics of enterprises with two types of effects on R&D innovation: Crowding-out and non-crowding-out. Using disclosed data from listed companies in China as the sample, the following conclusions were drawn. First, there are two types of motivation for enterprise financial assets: reservoir motivation and substitute motivation. This difference in motivation leads to whether there is a crowding-out effect of enterprise financialization on R&D innovation. Second, based on whether there is a crowding-out effect on enterprise R&D innovation, we found that the difference in reservoir motivation between the two types of samples is reflected in the intensity of inhibition, while the difference in substitute motivation is reflected in significance. Third, there are differences in the mechanism variables of financialization motivation among different samples. The moderating effect of equity concentration is reflected in its intensity, while the moderating effect of financing constraints is reflected in its significance

An Improved D-α-Tocopherol-Based Nanocarrier for Targeted Delivery of Doxorubicin with Reversal of Multidrug Resistance

Nanocarriers have recently emerged as an attractive platform for delivery of various types of therapeutics including anticancer agents. Previously, we developed an improved TPGS delivery system (PEG5K-VE2) which demonstrated improved colloidal stability and greater in vivo antitumor activity. Nevertheless, the application of this system is still limited by a relatively low drug loading capacity (DLC). In this study we report that incorporation of a fluorenylmethyloxycarbonyl (Fmoc) motif at the interfacial region of PEG5K-VE2 led to significant improvement of the system through the introduction of an additional mechanism of drug/carrier interaction. Doxorubicin (DOX) could be effectively loaded into PEG5K-Fmoc-VE2 micelles at a DLC of 39.9%, which compares favorably to most reported DOX nanoformulations. In addition, PEG5K-Fmoc-VE2/DOX mixed micelles showed more sustained release of DOX in comparison to the counterpart without Fmoc motif. MTT assay showed that PEG5K-Fmoc-VE2/DOX exerted significantly higher levels of cytotoxicity over DOX, Doxil as well as PEG5K-VE2/DOX in PC-3 and 4T1.2 cells. Cytotoxicity assay with NCI/ADR-RES, a drug resistant cell line, suggested that PEG5K-Fmoc-VE2 may have a potential to reverse the multidrug resistance, which was supported by its inhibition on P-gp ATPase. Pharmacokinetics (PK) and biodistribution studies showed an increased half-life in blood circulation and more effective tumor accumulation for DOX formulated in PEG5K-Fmoc-VE2 micelles. More importantly, DOX-loaded PEG5K-Fmoc-VE2 micelles showed an excellent safety profile with a MTD (~30 mg DOX/kg) that is about 3 times as much as that for free DOX. Finally, superior antitumor activity was demonstrated for PEG5K-Fmoc-VE2/DOX in both drug-sensitive (4T1.2 and PC-3) and drug-resistant (KB 8-5) tumor models compared to DOX, Doxil, and PEG5K-VE2/DOX

Clinical efficacy analysis of paxlovid in children with hematological diseases infected with the omicron SARS-CoV-2 new variant

ObjectiveTo summarize the clinical characteristics of children with hematological malignancies co-infected with novel coronavirus and explore the safety and effectiveness of Paxlovid treatment.MethodsFrom December 10, 2022, to January 20, 2023, the clinical data of children with hematological diseases diagnosed with novel coronavirus infection in the outpatient and emergency department of the Seventh Affiliated Hospital of Sun Yat-sen University were retrospectively analyzed.ResultsAccording to whether to give paxlovid or not, it is divided into group A (paxlovid group) and group B (non-paxlovid group). The length of fever was 1–6 days in group A and 0–3 days in group B. The viral clearance time was shorter in group A than in group B. The inflammatory indexes CRP and PCT were significantly higher in group A than in group B (P < 0.05). Twenty patients were followed up for 1 month after leaving the hospital, and there were 5 cases of reappearance of fever, 1 case of increased sleep, 1 case of physical fatigue and 1 case of loss of appetite within 2 weeks.ConclusionsPaxlovid has no apparent adverse reactions in children 12 years old and younger with underlying hematological diseases infected with the new coronavirus. Focusing on the interaction between paxlovid and other drugs is necessary during the treatment

The United States COVID-19 Forecast Hub dataset

Academic researchers, government agencies, industry groups, and individuals have produced forecasts at an unprecedented scale during the COVID-19 pandemic. To leverage these forecasts, the United States Centers for Disease Control and Prevention (CDC) partnered with an academic research lab at the University of Massachusetts Amherst to create the US COVID-19 Forecast Hub. Launched in April 2020, the Forecast Hub is a dataset with point and probabilistic forecasts of incident cases, incident hospitalizations, incident deaths, and cumulative deaths due to COVID-19 at county, state, and national, levels in the United States. Included forecasts represent a variety of modeling approaches, data sources, and assumptions regarding the spread of COVID-19. The goal of this dataset is to establish a standardized and comparable set of short-term forecasts from modeling teams. These data can be used to develop ensemble models, communicate forecasts to the public, create visualizations, compare models, and inform policies regarding COVID-19 mitigation. These open-source data are available via download from GitHub, through an online API, and through R packages

Study on window-opening habit of urban residential buildings in Liaoning province

Residents' window-opening behavior is the most basic method to obtain fresh air and improve the indoor environment, and is also an important factor affecting building energy consumption. The behavior of opening and closing windows of urban residents will be different due to regional differences. However, there are less of the thorough enough research on the time and seasonal habit of residents’ window-opening behavior in Liaoning. This paper investigated the window-opening behavior and its influencing factors of 28 typical urban households in natural ventilation and mechanical ventilation houses in Liaoning province by questionnaire survey and on-site testing. The opening and closing behavior of residents’ windows were continuously monitored online for one year by using magnetic sensors of XIAOMI brand. The long-term monitoring results showed that the window-opening behavior of residents in Liaoning has strong seasonality. In summer, the window-opening time is relatively longer, and often more than 24 hours. What’s more, most local residents have the habit of opening windows for ventilation when they get up in the morning, even in the cold winter. The understanding of the window-opening behavior of residents in this area can provide strong support for architectural design or renovation strategy

Analysis of Acoustic Wave Frequency Spectrum Characters of Rock Mass under Blasting Damage Based on the HHT Method

The limitation associated with Fourier transform and wavelet analysis that they often fail to produce satisfactory resolution simultaneously in time and frequency when dealing with nonlinear and nonstationary signals is frequently encountered. Therefore, this paper aims at using the HHT (Hilbert–Huang transform) method, which is built on the basis of the EMD- (empirical mode decomposition-) based wavelet threshold denoising technique and the Hilbert transform, to analyze the blasting vibration signals in a south China lead-zinc mine. The analysis is conducted in terms of three-dimensional Hilbert spectrum, marginal spectrum, and instantaneous energy spectrum. The results indicate that the frequencies of the blasting vibration signals lie mainly within 0∼200 Hz, which consists of more than 90% of the total signal energy. At the onset of the blasting, the vibration frequency tends to be low, with the frequency that is less than 50 Hz being dominant. By using instantaneous energy spectrum, which can reveal the condition of energy release for detonator explosion, the initiation moments of detonators with 7 time-lag levels are accurately identified. This accurate identification demonstrates the superiority of the HHT method in coping with nonlinear and nonstationary signals. Additionally, the HHT method that is characterized by adaptivity, completeness, strong reconfigurability, and high accuracy provides an opportunity for reflecting signals’ change features with regard to time domain, frequency domain, and energy irrespective of the limitation of the Heisenberg uncertainty principle

Youth hawkerprise campaign

This paper presents the Youth Hawkerprise Campaign, the first-ever communication campaign in Singapore to encourage youths to join the hawker trade, organised by four final year students from the Wee Kim Wee School of Communication and Information. Targeted at youths aged 17-35, this campaign aims to raise awareness of the lack of youths in the hawker trade and challenge negative hawker stereotypes by utilising positive images and success stories of existing youth hawkers. Focusing on interactive platforms such as a photo exhibition and a workshop with networking opportunities, the campaign strives to provide opportunities for youths with the passion in culinary arts to consider the potential of honing their abilities and setting up a viable food business at a hawker centre. It seeks to keep the street food culture in Singapore alive and ensure that affordable dining will be available for generations of Singaporeans to come. This paper summarises the primary and secondary research that formulated key campaign strategies. It outlines the process from creative conception to execution of the campaign initiatives and examines the campaign’s tactical effectiveness through extensive evaluative measures. Evaluation includes pre- and post-campaign surveys, metrics from online and mass media publications, as well as an analysis of all media coverage. This report also provides future recommendations for the continuation of the campaign’s pioneering initiatives in the hawker industry. Detailed appendices that support the main text with precise graphs, tables and charts as well as original collateral designs are accompanied for further reference.Bachelor of Communication Studie

Youth hawkerprise campaign

This paper presents the Youth Hawkerprise Campaign, the first-ever communication campaign in Singapore to encourage youths to join the hawker trade, organised by four final year students from the Wee Kim Wee School of Communication and Information. Targeted at youths aged 17-35, this campaign aims to raise awareness of the lack of youths in the hawker trade and challenge negative hawker stereotypes by utilising positive images and success stories of existing youth hawkers. Focusing on interactive platforms such as a photo exhibition and a workshop with networking opportunities, the campaign strives to provide opportunities for youths with the passion in culinary arts to consider the potential of honing their abilities and setting up a viable food business at a hawker centre. It seeks to keep the street food culture in Singapore alive and ensure that affordable dining will be available for generations of Singaporeans to come. This paper summarises the primary and secondary research that formulated key campaign strategies. It outlines the process from creative conception to execution of the campaign initiatives and examines the campaign’s tactical effectiveness through extensive evaluative measures. Evaluation includes pre- and post-campaign surveys, metrics from online and mass media publications, as well as an analysis of all media coverage. This report also provides future recommendations for the continuation of the campaign’s pioneering initiatives in the hawker industry. Detailed appendices that support the main text with precise graphs, tables and charts as well as original collateral designs are accompanied for further reference.Bachelor of Communication Studie