Mechanisms of alkane reactions over platinum and tungsten carbide catalysts.

Doctorat en Sciencesinfo:eu-repo/semantics/nonPublishe

Prediction of depression onset risk among middle-aged and elderly adults using machine learning and Canadian Longitudinal Study on Aging cohort

This research was undertaken, in part, thanks to funding from the Canada Research Chairs program, Alberta Innovates, Mental Health Foundation, MITACS Accelerate program, Simon & Martina Sochatsky Fund for Mental Health, the Alberta Synergies in Alzheimer's and Related Disorders (SynAD) program and University of Alberta Hospital Foundation.Peer reviewedPostprin

circGprc5a Promoted Bladder Oncogenesis and Metastasis through Gprc5a-Targeting Peptide

Bladder cancer is a serious cancer in the world, especially in advanced countries. Bladder cancer stem cells (CSCs) drive bladder tumorigenesis and metastasis. Circular RNAs (circRNAs) are involved in many biological processes, but their roles in bladder oncogenesis and bladder CSCs are unclear. Here, we identified that circGprc5a is upregulated in bladder tumors and CSCs. circGpr5a knockdown impairs the self-renewal and metastasis of bladder CSCs, and its overexpression exerts an opposite role. circGpr5a has peptide-coding potential and functions through a peptide-dependent manner. circGprc5a-peptide binds to Gprc5a, a surface protein highly expressed in bladder CSCs. Gprc5a knockout inhibits the bladder CSC self-renewal and metastasis. circGprc5a-peptide-Gprc5a can be utilized to target bladder cancer and bladder CSCs. Keywords: bladder cancer, cancer stem cells, Gprc5a, peptid