Safety-aware Semi-end-to-end Coordinated Decision Model for Voltage Regulation in Active Distribution Network

Prediction plays a vital role in the active distribution network voltage regulation under the high penetration of photovoltaics. Current prediction models aim at minimizing individual prediction errors but overlook their collective impacts on downstream decision-making. Hence, this paper proposes a safety-aware semi-end-to-end coordinated decision model to bridge the gap from the downstream voltage regulation to the upstream multiple prediction models in a coordinated differential way. The semi-end-to-end model maps the input features to the optimal var decisions via prediction, decision-making, and decision-evaluating layers. It leverages the neural network and the second-order cone program (SOCP) to formulate the stochastic PV/load predictions and the var decision-making/evaluating separately. Then the var decision quality is evaluated via the weighted sum of the power loss for economy and the voltage violation penalty for safety, denoted by regulation loss. Based on the regulation loss and prediction errors, this paper proposes the hybrid loss and hybrid stochastic gradient descent algorithm to back-propagate the gradients of the hybrid loss with respect to multiple predictions for enhancing decision quality. Case studies verify the effectiveness of the proposed model with lower power loss for economy and lower voltage violation rate for safety awareness

Synthesis of a Dual Functional Anti-MDR Tumor Agent PH II-7 with Elucidations of Anti-Tumor Effects and Mechanisms

Multidrug resistance mediated by P-glycoprotein in cancer cells has been a major issue that cripples the efficacy of chemotherapy agents. Aimed for improved efficacy against resistant cancer cells, we designed and synthesized 25 oxindole derivatives based on indirubin by structure-activity relationship analysis. The most potent one was named PH II-7, which was effective against 18 cancer cell lines and 5 resistant cell lines in MTT assay. It also significantly inhibited the resistant xenograft tumor growth in mouse model. In cell cycle assay and apoptosis assay conducted with flow cytometry, PH II-7 induced S phase cell cycle arrest and apoptosis even in resistant cells. Consistently revealed by real-time PCR, it modulates the expression of genes related to the cell cycle and apoptosis in these cells, which may contributes to its efficacy against them. By side-chain modification and FITC-labeling of PH II-7, we were able to show with confocal microscopy that not only it was not pumped by P-glycoprotein, it also attenuated the efflux of Adriamycin by P-glycoprotein in MDR tumor cells. Real-time PCR and western blot analysis showed that PH II-7 down-regulated MDR1 gene via protein kinase C alpha (PKCA) pathway, with c-FOS and c-JUN as possible mediators. Taken together, PH II-7 is a dual-functional compound that features both the cytotoxicity against cancer cells and the inhibitory effect on P-gp mediated drug efflux

The critical role of carbon in marrying silicon and graphite anodes for high‐energy lithium‐ion batteries

Abstract Increasing the energy density of conventional lithium‐ion batteries (LIBs) is important for satisfying the demands of electric vehicles and advanced electronics. Silicon is considered as one of the most‐promising anodes to replace the traditional graphite anode for the realization of high‐energy LIBs due to its extremely high theoretical capacity, although its severe volume changes during lithiation/delithiation have led to a big challenge for practical application. In contrast, the co‐utilization of Si and graphite has been well recognized as one of the preferred strategies for commercialization in the near future. In this review, we focus on different carbonaceous additives, such as carbon nanotubes, reduced graphene oxide, and pyrolyzed carbon derived from precursors such as pitch, sugars, heteroatom polymers, and so forth, which play an important role in constructing micrometer‐sized hierarchical structures of silicon/graphite/carbon (Si/G/C) composites and tailoring the morphology and surface with good structural stability, good adhesion, high electrical conductivity, high tap density, and good interface chemistry to achieve high capacity and long cycling stability simultaneously. We first discuss the importance and challenge of the co‐utilization of Si and graphite. Then, we carefully review and compare the improved effects of various types of carbonaceous materials and their associated structures on the electrochemical performance of Si/G/C composites. We also review the diverse synthesis techniques and treatment methods, which are also significant factors for optimizing Si/G/C composites. Finally, we provide a pertinent evaluation of these forms of carbon according to their suitability for commercialization. We also make far‐ranging suggestions with regard to the selection of proper carbonaceous materials and the design of Si/G/C composites for further development

The critical role of carbon in marrying silicon and graphite anodes for high‐energy lithium‐ion batteries

Abstract Increasing the energy density of conventional lithium‐ion batteries (LIBs) is important for satisfying the demands of electric vehicles and advanced electronics. Silicon is considered as one of the most‐promising anodes to replace the traditional graphite anode for the realization of high‐energy LIBs due to its extremely high theoretical capacity, although its severe volume changes during lithiation/delithiation have led to a big challenge for practical application. In contrast, the co‐utilization of Si and graphite has been well recognized as one of the preferred strategies for commercialization in the near future. In this review, we focus on different carbonaceous additives, such as carbon nanotubes, reduced graphene oxide, and pyrolyzed carbon derived from precursors such as pitch, sugars, heteroatom polymers, and so forth, which play an important role in constructing micrometer‐sized hierarchical structures of silicon/graphite/carbon (Si/G/C) composites and tailoring the morphology and surface with good structural stability, good adhesion, high electrical conductivity, high tap density, and good interface chemistry to achieve high capacity and long cycling stability simultaneously. We first discuss the importance and challenge of the co‐utilization of Si and graphite. Then, we carefully review and compare the improved effects of various types of carbonaceous materials and their associated structures on the electrochemical performance of Si/G/C composites. We also review the diverse synthesis techniques and treatment methods, which are also significant factors for optimizing Si/G/C composites. Finally, we provide a pertinent evaluation of these forms of carbon according to their suitability for commercialization. We also make far‐ranging suggestions with regard to the selection of proper carbonaceous materials and the design of Si/G/C composites for further development

MH1 domain of SMAD4 binds N-terminal residues of the homeodomain of Hoxc9

Smad family proteins mediate signaling initiated by bone morphogenetic proteins (BMPs). Upon BMP stimulation, the Smads such as Smad4 can interact directly with Hox proteins and suppress their DNA-binding activity. Although the interaction between the MAD-homology 1 (MH1) domain of Smad4 and Hox was found to regulate the transcription activity of Hox proteins, the molecular mechanism is not well characterized and direct contact residues remain to be elucidated. in the present study, the interaction between the recombinant homeodomain (HD) of Hoxc9 and MH1 domain of Smad4 was investigated with the use of the GST pull-down assay, surface plasmon resonance (SPR) analysis as well as multidimensional nuclear magnetic resonance (NMR) techniques. The Hoxc9-HD was precipitated with the GST-fused Smad4-MH1 but not with GST alone, demonstrating a direct interaction between Hoxc9-HD and Smad4-MH1 in vitro. SPR measurement further confirmed a moderately strong interaction (K-d approximate to 400 nM) between these two domains. Moreover, NMR titration experiments showed that a strong and specific binding occurred between Smad4-MH1 and Hoxc9-HD. NMR triple-resonance experiments and backbone assignments revealed that the N-terminal arm of Hoxc9-HD, spanning the positive-charged DNA-binding segment of Arg190-Arg196, was intimately involved in the interaction with Smad4-MH1. Ala-substitutions ofArg190-Arg196 led to the loss of interaction between Hoxc9-HD and Smad4-MH1 in both GST-pull down assay and SPR analysis; further provided functional evidence for the critical role of this positive-charged region in binding to Smad4-MH1. This suggested that Smad4-MH1 could occupy one of the DNA binding sites of Hoxc9 and consequently inhibits its transcription activity. The above results are in good agreement and yield the first insight into the interaction between the homeodomain of Hox proteins and the conserved MH1 domain of Smad family proteins. (c) 2008 Elsevier B.V. All rights reserved