Impacts of Cultivated Land Reclamation on the Climate and Grain Production in Northeast China in the Future 30 Years

China, as a large agricultural country as well as a major country with great demand for grain, has played a more and more important role in the international grain market. As Northeast China is one of the major commodity grain bases in China as well as one of the regions with the highest intensity of human activities, it plays an important role in influencing the global food security. This study first generally analyzed the cultivated land reclamation and the climate change of temperature and precipitation in Northeast China during 2000–2010. Then, on the basis of these data, the climatic effects of cultivated land reclamation in Northeast China during 2030–2040 were simulated by the weather research forecast (WRF) model. Finally, the possible effects of the climate change on the grain yield and the potential influence on the food security were analyzed. The simulation result indicated that the temperature in Northeast China would be increasing on the whole, while the precipitation would be decreasing. The result of this study can provide some theoretical support to the agricultural economic development in Northeast China and serve the national macropolicy and food security strategy of the whole China

Lower gut abundance of Eubacterium rectale is linked to COVID-19 mortality

IntroductionEmerging preclinical and clinical studies suggest that altered gut microbiome composition and functions are associated with coronavirus 2019 (COVID- 19) severity and its long-term complications. We hypothesize that COVID-19 outcome is associated with gut microbiome status in population-based settings.MethodsGut metagenomic data of the adult population consisting of 2871 subjects from 16 countries were obtained from ExperimentHub through R, while the dynamic death data of COVID-19 patients between January 22, 2020 and December 8, 2020 in each country was acquired from Johns Hopkins Coronavirus Resource Center. An adjusted stable mortality rate (SMR) was used to represent these countries’ mortality and correlated with the mean relative abundance (mRA) of healthy adult gut microbiome species.ResultsAfter excluding bacterial species with low prevalence (prevalence <0.2 in the included countries), the β-diversity was significantly higher in the countries with high SMR when compared with those with median or low SMR (p <0.001). We then identified the mRA of two butyrate producers, Eubacterium rectale and Roseburia intestinalis, that were negatively correlated with SMR during the study period. And the reduction of these species was associated with severer COVID-19 manifestation.ConclusionPopulation-based microbiome signatures with the stable mortality rate of COVID-19 in different countries suggest that altered gut microbiome composition and functions are associated with mortality of COVID-19

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two

Background The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd. Methods We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background. Results First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001). Conclusions In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival

Stakeholders of Voluntary Forest Carbon Offset Projects in China: An Empirical Analysis

Climate change is one of the defining challenges facing the planet. Voluntary forest carbon offset project which has the potential to boost forest carbon storage and mitigate global warming has aroused the global concern. The objective of this paper is to model the game situation and analyze the game behaviors of stakeholders of voluntary forest carbon offset projects in China. A stakeholder model and a Power-Benefit Matrix are constructed to analyze the roles, behaviors, and conflicts of stakeholders including farmers, planting entities, communities, government, and China Green Carbon Foundation. The empirical analysis results show that although the stakeholders have diverse interests and different goals, a win-win solution is still possible through their joint participation and compromise in the voluntary forest carbon offset project. A wide governance structure laying emphasis on benefit balance, equality, and information exchanges and being regulated by all stakeholders has been constructed. It facilitates the agreement among the stakeholders with conflicting or different interests. The joint participation of stakeholders in voluntary forest carbon offset projects might change the government-dominated afforestation/reforestation into a market, where all participators including government are encouraged to cooperate with each other to improve the condition of fund shortage and low efficiency

Interactions between Climate, Socioeconomics, and Land Dynamics in Qinghai Province, China: A LUCD Model-Based Numerical Experiment

This simulation-based research produces a set of forecast land use data of Qinghai Province, China, applying the land use change dynamics (LUCD) model. The simulation results show that the land use pattern will almost keep being consistent in the period from 2010 to 2050 with that in 2000 in Qinghai Province. Grassland and barren or sparsely vegetated land will cover more than 80% of the province’s total area. The land use change will be inconspicuous in the period from 2010 to 2050 involving only 0.49% of the province’s land. The expansion of urban and built-up land, grassland, and barren or sparsely vegetated land and the area reduction of mixed dryland/irrigated cropland and pasture, water bodies, and snow or ice will dominate land use changes of the case study area. The changes of urban and built-up land and mixed dryland/irrigated cropland and pasture will slow down over time. Meanwhile, the change rates of water bodies, snow and ice, barren or sparsely vegetated land, and grassland will show an inverted U-shaped trajectory. Except for providing underlying surfaces for RCMs for future climate change assessment, this empirical research of regional land use change may enhance the understanding of land surface system dynamics

A Framework for the Land Use Change Dynamics Model Compatible with RCMs

A framework of land use change dynamics (LUCD) model compatible with regional climate models (RCMs) is introduced in this paper. The LUCD model can be subdivided into three modules, namely, economic module, vegetation change module, and agentbased module. The economic module is capable of estimating the demand of land use changes in economic activities maximizing economic utility. A computable general equilibrium (CGE) modeling framework is introduced and an approach to introduce land as a production factor into the economic module is proposed. The vegetation change module provides the probability of vegetation change driven by climate change. The agroecological zone (AEZ) model is supposed to be the optimal option for constructing the vegetation change module. The agent-based module identifies whether the land use change demand and vegetation change can be realized and provides the land use change simulation results which are the underlying surfaces needed by RCM. By importing the RCMs&apos; simulation results of climate change and providing the simulation results of land use change for RCMs, the LUCD model would be compatible with RCMs. The coupled simulation system composed of LUCD and RCMs can be very effective in simulating the land surface processes and their changing patterns

A Framework for the Land Use Change Dynamics Model Compatible with RCMs

A framework of land use change dynamics (LUCD) model compatible with regional climate models (RCMs) is introduced in this paper. The LUCD model can be subdivided into three modules, namely, economic module, vegetation change module, and agent-based module. The economic module is capable of estimating the demand of land use changes in economic activities maximizing economic utility. A computable general equilibrium (CGE) modeling framework is introduced and an approach to introduce land as a production factor into the economic module is proposed. The vegetation change module provides the probability of vegetation change driven by climate change. The agroecological zone (AEZ) model is supposed to be the optimal option for constructing the vegetation change module. The agent-based module identifies whether the land use change demand and vegetation change can be realized and provides the land use change simulation results which are the underlying surfaces needed by RCM. By importing the RCMs' simulation results of climate change and providing the simulation results of land use change for RCMs, the LUCD model would be compatible with RCMs. The coupled simulation system composed of LUCD and RCMs can be very effective in simulating the land surface processes and their changing patterns

Impacts of Future Urban Expansion on Regional Climate in the Northeast Megalopolis, USA

In this paper, evidences for influences of future urban expansion on regional climate in the Northeast megalopolis, USA, are presented. The model-based analysis shows that future urban expansion will significantly result in regional climate change. An average annual temperature increase ranging from 2°C to 5°C in new urban area and an average annual temperature decrease ranging from 0.40°C to 1.20°C in the south of the megalopolis will be caused by future urban expansion. The average annual precipitation of the simulation area will decrease due to future urban expansion by 5.75 mm, 7.10 mm, and 8.35 mm in the periods of 2010–2020, 2040–2050, and 2090–2100, respectively. The warming effect of future urban expansion in original and new urban area and drought effects in nonurban area will be more serious in summer than in winter. A cooling effect will turn up in original urban area in winter. This research further shows that a study at the scale of megalopolis helps to understand the integrated effect of combination and interaction of multiple cities and their surrounding areas which may crucially determine regional climate pattern and should be highly valued in the future