Additional file 1 of Adrenarche-accompanied rise of adrenal sex steroid precursors prevents NAFLD in Young Female rats by converting into active androgens and inactivating hepatic Srebf1 signaling

Supplementary Material 1

Additional file 1: of Decreased MUC1 in endometrium is an independent receptivity marker in recurrent implantation failure during implantation window

Table S1. Relationship between female age and receptivity markers. Table S2. H-score comparison between endometritis/endometriosis and non-endometritis/non-endometriosis women. (DOCX 16 kb

Does non-cavity distorting intramural fibroid affect endometrium around the time of embryo implantation?

The effect of the intramural fibroids not distorting the cavity remains controversial on implantation and pregnancy. The aim of this study was to examine the impact of non-cavity distorting intramural fibroids on endometrium. Fifty-six women with non-cavity distorting intramural fibroid were recruited in this study. Paired endometrial specimens, one from beneath the fibroid (ipsilateral endometrium) and the other from the opposite side of uterine cavity, away from the fibroid (contralateral endometrium) were obtained 7–9 days after the luteinizing hormone surge in a natural cycle. Histological dating, Mucin1 and Glycodelin expression and uterine natural killer (uNK) cell density were compared between the paired samples. The median (IQR) H-score of Mucin1 staining in the ipsilateral luminal epithelium was 210% (142–230%), which was significantly (p < 0.05) higher than that of the contralateral luminal endometrium (157%, IQR 114–176%). There was no significant difference in Mucin1 expression in the glandular epithelium. There was no significant difference in Glycodelin expression in luminal and glandular epithelium, uNK cells density or histological dating results between the paired endometrial samples. In conclusion, it is uncertain whether the altered expression of Mucin1 in luminal epithelium alone may have impact on implantation when other markers are not changed.</p

A photon-level broadband dual-comb interferometer for turbulent open-air trace gases detection application

Open-path dual-comb spectroscopy (DCS) significantly enhances our understanding of regional trace gases. However, due to technical challenges, cost considerations, and eye-safety regulations, its sensing range and flexibility remain limited. The photon-counting DCS demonstrated recently heralds potential innovations over open-path DCS. Nevertheless, a major challenge in open-air applications of this approach lies in accurately extracting information from the arrival time of photons that have traversed the turbulent atmosphere. Here, we demonstrate a photon-level dual-comb interferometer for field deployment in open-air environments, uniquely designed to counteract the impact of optical path-length variations caused by atmospheric turbulence and fiber-length wandering. Under variable optical path-length conditions, 20nm broadband absorption spectrum of H13C14N is acquired, with the power per comb line detected as low as 4 attowatt . Furthermore, this photon-level DCS achieves comb-line resolution with a quantum-noise-limited signal-to-noise (SNR). This paves the way for novel open-path DCS applications, including non-cooperative target sensing and sensing over a hundred-kilometers range, all within a portable, fieldable, eye-safety and low power consumption system

L'Auto-vélo : automobilisme, cyclisme, athlétisme, yachting, aérostation, escrime, hippisme / dir. Henri Desgranges

03 avril 19361936/04/03 (A37,N12892)

Unsupervised clustering of all gene expression in 9 paired samples, 3 with recurrent implantation failure (RIF), 3 with recurrent miscarriage (RM), and 3 fertile controls (C).

<p>Unsupervised clustering of all gene expression in 9 paired samples, 3 with recurrent implantation failure (RIF), 3 with recurrent miscarriage (RM), and 3 fertile controls (C).</p

The median expression of genes in each paired samples.

<p>The median expression of genes in each paired samples.</p

Histogram showing the coefficients of Spearman's rank correlation in different groups.

<p>Results shown were mean ± SE. *t test p = 0.027; SE: standard error; RIF: recurrent implantation failure; RM: recurrent miscarriage; C: fertile control.</p

Scattered plots showed positive correlation of transcriptome in paired samples of each subjects.

<p>RIF: recurrent implantation failure; RM: recurrent miscarriage; C: fertile control.</p

Distribution and demographic characteristics of the study population.

<p>Distribution and demographic characteristics of the study population.</p