Monolithic Metamaterial-Integrated Graphene Terahertz Photodetector with Wavelength and Polarization Selectivity

The frequency spectra and polarization states of terahertz waves can convey significant information about physical interactions and material properties. Compact and miniaturized on-chip platforms for effective capturing of these quantities are being extensively investigated because of their promising potential for paramount applications of terahertz technology such as in situ sensing and characterization. Here, we present a metamaterial–graphene hybrid device that integrates the functions of photodetection, wavelength, and polarization selectivity into a monolithic architecture. Leveraging the ultrahigh design freedom of metamaterial optical properties and the electronically controllable hot-carrier-assisted photothermoelectric effect in graphene, our detector shows resonantly enhanced photoresponse at two specific target wavelengths with orthogonal polarizations. We demonstrate its versatile capabilities for spectrally selective and polarization resolved imaging on a single-chip platform that is free from advanced optical components. Our strategy is beneficial to the future development of multifunctional, compact, and low-cost terahertz sensors

Multivariate analysis of the factors related to post-operative distant metastasis.

<p>OR, odd ratio.</p

Cox model regression analysis of the breast cancer prognostic factors.

<p>Cox model regression analysis of the breast cancer prognostic factors.</p

Correlations between Ki67 distribution pattern and distant metastasis (n(%)).

<p>Correlations between Ki67 distribution pattern and distant metastasis (n(%)).</p

Correlations between distribution pattern of Ki67 expression and clinic-pathological features (n = 1086).

<p><i>P₁</i>_, Ki67⁺ group compared to Ki67⁻ group; <i>P₂</i>_, Diffuse type compared to Ki67− group; <i>P₃</i>_, borderline type compared to diffuse type.</p

Nanosecond-Response Speed Sensor Based on Perovskite Single Crystal Photodetector Array

A nanosecond-response speed sensor is demonstrated based on a CH₃NH₃PbI₃ perovskite single crystal photodetector array. The responsivity of the CH₃NH₃PbI₃ photodetector unit is as high as 1.55 × 10² A/W under 1.93 × 10^–2 mW/cm² illumination with a 532 nm laser. The ultrafast response time of less than 12.5 ns makes it possible for ultra-high-speed detection. Owing to the uniformity of as-prepared CH₃NH₃PbI₃ single crystals, each array element shows a consistent performance. When a shelter moves across the photodetector array, the time delay of the photoresponses between two neighboring array elements can be recorded promptly. Therefore, the speed of the moving shelter can be calculated easily. Besides speed sensing, the ability to capture the trajectory of a moving object is also demonstrated. The nanosecond-response speed sensor presented here demonstrates great potential for applying in high-speed detection

Plasma Metabolomic Profiling to Reveal Antipyretic Mechanism of <i>Shuang-Huang-Lian</i> Injection on Yeast-Induced Pyrexia Rats

<div><p><i>Shuang-huang-lian</i> injection (<i>SHLI</i>) is a famous Chinese patent medicine, which has been wildly used in clinic for the treatment of acute respiratory tract infection, pneumonia, influenza, etc. The existing randomized controlled trial (RCT) studies suggested that <i>SHLI</i> could afford a certain anti-febrile action. However, seldom does research concern the pharmacological mechanisms of <i>SHLI</i>. In the current study, we explored plasma metabolomic profiling technique and selected potential metabolic markers to reveal the antipyretic mechanism of <i>SHLI</i> on yeast-induced pyrexia rat model using UPLC-Q-TOF/MS coupled with multivariate statistical analysis and pattern recognition techniques. We discovered a significant perturbance of metabolic profile in the plasma of fever rats and obvious reversion in <i>SHLI</i>-administered rats. Eight potential biomarkers, i.e. 1) 3-hydeoxybutyric acid, 2) leucine, 3) 16∶0 LPC, 4) allocholic acid, 5) vitamin B₂, 6) Cys-Lys-His, 7) 18∶2 LPC, and 8) 3-hydroxychola-7, 22-dien-24-oic acid, were screened out by OPLS-DA approach. Five potential perturbed metabolic pathways, i.e. 1) valine, leucine, and isoleucine biosynthesis, 2) glycerophospholipid metabolism, 3) ketone bodies synthesis and degradation, 4) bile acid biosynthesis, and 5) riboflavin metabolism, were revealed to relate to the antipyretic mechanisms of <i>SHLI</i>. Overall, we investigated antipyretic mechanisms of <i>SHLI</i> at metabolomic level for the first time, and the obtained results highlights the necessity of adopting metabolomics as a reliable tool for understanding the holism and synergism of Chinese patent drug.</p></div

Metabolites selected by OPLS-DA with VIP >1 and significant test <i>P</i><0.05 between the pyretic model group and the normal control group.

<p>Note: ^aMetabolites were identified based on database information in METLIN, Lipid MAPs or HMDB; ↑showed up-regulated metabolites and ↓showed down-regulated metabolites; ^#<i>p<0.05</i>, ^{# #}<i>p<0.01</i>, ^{# # #}<i>p<0.001</i> Model vs. normal control; *<i>p<0.05</i>, **<i>p<0.01</i>, ***<i>p<0.001</i> SHLI vs. Model.</p

The changing trend of rectal temperatures in NC, M and <i>SHLI</i> treatment group.

<p>Data was expressed as mean ± SD. ^###<i>P</i><0.001 vs., NC group; **<i>P</i><0.01 vs., M group.</p

Typical base peak intensity (BPI) chromatograms ofplasma samples from each groups.

<p>(A) NC at positive ion mode. (B) M at positive ion mode (C) <i>SHLI</i> treatment at positive mode (Blue arrows show drug induced components).</p