PERICYTES ARE MORE THAN MSCS: A COMPARISON OF THREE CELL POPULATIONS

Master'sMASTER OF ENGINEERIN

THE APPLICATION OF BLOOD-DERIVED ANGIOGENIC CELLS (BDACS) IN A MURINE HIND LIMB ISCHEMIA MODEL

Ph.DDOCTOR OF PHILOSOPH

All-cause mortality in metabolically healthy individuals was not predicted by overweight and obesity

BACKGROUND Metabolically healthy obesity (MHO) and metabolically healthy overweight (MH-OW) have been suggested to be important and emerging phenotypes with an increased risk of cardiovascular disease (CVD). However, whether MHO and MH-OW are associated with all-cause mortality remains inconsistent. METHODS The association of MHO and MH-OW and all-cause mortality was determined in a Chinese community-based prospective cohort study (the Kailuan study), including 93,272 adults at baseline. Data were analyzed from 2006 to 2017. Participants were categorized into 6 mutually exclusive groups, according to BMI and metabolic syndrome (MetS) status. The primary outcome was all-cause death, and accidental deaths were excluded. RESULTS During a median follow-up of 11.04 years (interquartile range, 10.74-11.22 years), 8977 deaths occurred. Compared with healthy participants with normal BMI (MH-NW), MH-OW participants had the lowest risk of all-cause mortality (multivariate-adjusted HR [aHR], 0.926; 95% CI, 0.861-0.997), whereas there was no increased or decreased risk for MHO (aHR, 1.009; 95% CI, 0.886-1.148). Stratified analyses and sensitivity analyses further validated that there was a nonsignificant association between MHO and all-cause mortality. CONCLUSIONS Overweight and obesity do not predict increased risk of all-cause mortality in metabolic healthy Chinese individuals

Genome wide association study on feed conversion ratio using imputed sequence data in chickens

Objective Feed consumption contributes a large percentage for total production costs in the poultry industry. Detecting genes associated with feeding traits will be of benefit to improve our understanding of the molecular determinants for feed efficiency. The objective of this study was to identify candidate genes associated with feed conversion ratio (FCR) via genome-wide association study (GWAS) using sequence data imputed from single nucleotide polymorphism (SNP) panel in a Chinese indigenous chicken population. Methods A total of 435 Chinese indigenous chickens were phenotyped for FCR and were genotyped using a 600K SNP genotyping array. Twenty-four birds were selected for sequencing, and the 600K SNP panel data were imputed to whole sequence data with the 24 birds as the reference. The GWAS were performed with GEMMA software. Results After quality control, 8,626,020 SNPs were used for sequence based GWAS, in which ten significant genomic regions were detected to be associated with FCR. Ten candidate genes, ubiquitin specific peptidase 44, leukotriene A4 hydrolase, ETS transcription factor, R-spondin 2, inhibitor of apoptosis protein 3, sosondowah ankyrin repeat domain family member D, calmodulin regulated spectrin associated protein family member 2, zinc finger and BTB domain containing 41, potassium sodium-activated channel subfamily T member 2, and member of RAS oncogene family were annotated. Several of them were within or near the reported FCR quantitative trait loci, and others were newly reported. Conclusion Results from this study provide valuable prior information on chicken genomic breeding programs, and potentially improve our understanding of the molecular mechanism for feeding traits

Development of a Nonlinear Piezoelectric Energy Harvester for Alternating Air Load

The demand for energy-harvesting technology is steadily growing in the field of self-powered wireless sensor systems for use in pneumatic systems. The purpose of this research was to study an energy harvester excited by alternating air load in a pneumatic system. The harvester was designed to consist of a power chamber and a compressed chamber, and to the bottom of the power chamber a piezoelectric patch as been affixed. The harvester is excited by the changing pressure, which can be adjusted through changing volume, and the alternating air pressure energy can be harvested through the deformation of the piezoelectric patch. A test system was built and a prototype device was tested under various experimental conditions. The test results show that the energy generation performance of the harvester can be influenced by varying the volume compression parameters, with the output voltage increasing when the flow increases. The maximal output voltage and power are 24.7 V and 1.06 mW, respectively. An effective power of 0.28 mW was measured across the 200 kΩ resistor at a pressure of 200 kPa and a cycle time of 2.5 s with a flow of 150 L/min

Classification de l’îlot de chaleur urbain et des journées chaudes en été grâce aux Types de Temps Sensibles (TTS) à l’échelle de l’aire grenobloise (2019-2022)

La méthode de classification des types de temps sensible (TTS) permet d’identifier des situations météorologiques locales par la classification de cinq variables météorologiques : l’amplitude thermique journalière, les précipitations, l’humidité spécifique, la direction et la vitesse du vent. L’objectif de cette étude est l’identification des TTS pertinents pour caractériser les îlots de chaleur urbains (ICU) et les journées chaudes à l’échelle grenobloise.Les données utilisées concernent les données de réanalyse ERA5 pour la période 2002‐2022.Pour atteindre l’objectif ciblé et prendre en compte les biais des données, les variables d’entrée de la méthode originale ont été adaptées en convertissant les précipitations en une variable catégorielle fondée sur des seuils et en supprimant la variable de la direction du vent.En combinant les résultats de la classification avec les données de l’été 2019‐2022 et en attribuant les résultats de TTS au passé, il ressort qu’une classe de TTS locale identifie les ICU et les journées chaudes caractérisées par de fortes amplitudes thermiques diurnes, l’absence de précipitations, une humidité spécifique élevée et de faibles vitesses de vent, et que le nombre de ce TTS a augmenté entre le passé (1960‐2001) et le présent

Practice of PBL in the Reading Teaching Strategies

Combined PBL with some advanced foreign reading teaching strategies, we choose the most suitable way to give lessons and bring up students ability to think of questions. Based on teaching experience for several years, we propose some teaching strategies in English reading teaching to help students improve the efficiency and accuracy of reading with the help of PBL. After practice, students’ innovation and cooperation are strengthened and the width and depth of their questions are improved