A Wasserstein distance-based spectral clustering method for transaction data analysis

With the rapid development of online payment platforms, it is now possible to record massive transaction data. Clustering on transaction data significantly contributes to analyzing merchants' behavior patterns. This enables payment platforms to provide differentiated services or implement risk management strategies. However, traditional methods exploit transactions by generating low-dimensional features, leading to inevitable information loss. In this study, we use the empirical cumulative distribution of transactions to characterize merchants. We adopt Wasserstein distance to measure the dissimilarity between any two merchants and propose the Wasserstein-distance-based spectral clustering (WSC) approach. Based on the similarities between merchants' transaction distributions, a graph of merchants is generated. Thus, we treat the clustering of merchants as a graph-cut problem and solve it under the framework of spectral clustering. To ensure feasibility of the proposed method on large-scale datasets with limited computational resources, we propose a subsampling method for WSC (SubWSC). The associated theoretical properties are investigated to verify the efficiency of the proposed approach. The simulations and empirical study demonstrate that the proposed method outperforms feature-based methods in finding behavior patterns of merchants

PO-257 Application of biochemical index monitoring in Chinese hearing-impaired table tennis team

  Objective Using the theory of sports biochemistry, we can better complete the formulation of the training plan, the evaluations of training effect and the athlete's fatigue status, the real-time monitoring of training intensity and training amount as well as the function level of athletes and the comprehensive evaluation of nutritional status. To provide some theoretical guidance for the daily training of Chinese hearing-impaired table tennis team and to gradually establish the biochemical monitoring model for the Chinese Deaf Table tennis team, this subject has applied biochemical index monitoring to this team. Methods 2.1 Research Object 8 Athletes (male 4 female 4) of the Chinese hearing-impaired table tennis team were studied. The average height, weight, and age were 174.3±5.1cm, 65.4±11.6kg, 23.5±4.9 years respectively.2.2 Research Methods 2.2.1 Literature To find out the energy-supplying and metabolic characteristics of table tennis as well as the modes to accelerate the recovery period of body fatigue, we have searched a variety of literature on this purpose. The investigation of athletes' nutrition regulation, physical training and rehabilitation and other related research results lays a good foundation for the implementation of the project. 2.2.2 Expert Interview This paper discusses the energy metabolism characteristics of the hearing-impaired table tennis players by discussing with the coaches, athletes and experts and scholars of the national Hearing Impairment project group. The evaluation index and standard of athlete's body function, the method of training load monitoring, the way of nutrition regulation, the means of fatigue recovery and the process of physical training were discussed. 3.2.3 Field Investigation From April, 20th, 2017 to July, 10th, 2017, two researchers have long been in the center of national table tennis training located at Zheng Ding, Hebei province, to complete training monitoring and research services. Results 3 Research Results Phlebotomizing 7 of the Chinese hearing-impaired table tennis players in June,2nd,2017 and June 7th, 2017 respectively, The blood samples were analyzed by the team of experts and researchers in the Sports Physiology and Biochemistry Laboratory in Beijing Sport University. Part of the results was shown below in table 1, table 2. (1) Training intensity monitoring Huang Mengping had a slightly higher creatine kinase, a slight decrease in testosterone, a slight rise in cortisol, a lower testosterone/cortisol value, as well as an insignificant reduction in body function than the previous time. She should focus on the recovery of her body condition after training. In general, the testosterone, cortisol and testosterone/cortisol level in this team is slightly higher than the last time, blood urea lower than the previous. Strengthening the monitoring of exercise and nutrition and continuing to maintain a high body synthesis ability are favorable to intense competition. The overall creatinine level decreased, whereas 4 members of the team had insignificantly high creatinine, especially for Huang Mengping who first had appeared high level of it. Although this condition was not too severe to focus on, we should strengthen the regulation of athlete muscle injury and protect their kidney functions. (2) Monitoring of endocrine system indicators Both males and females had higher testosterone synthesis capabilities. They should continue to take the nutritional supplements. The T/C ratio of Tian Jiping has escalated sharply, but it was lower than that of other players. We should pay attention to his training load and promote the recovery training. (3) Monitoring of Iron Metabolic Index Huang Mengping's hemoglobin value and RBC value have been slightly elevated this time. It is suggested that she should keep on to take nutritional supplements and strengthen aerobic endurance training. Hemoglobin for Wang Zhe and Lin Huan (slightly decreased this time) was higher than their counterparts. The ability to transport oxygen was excellent, and it is agreeable to keep on. They need to continue to maintain and promote the body's oxygen reserve capacity. At the same time, they can also upgrade their overall red blood cell levels. Men have seen a high level of hemoglobin and the number of red blood cells as well as robust capabilities of oxymoron reservation and transportation. It is recommended to enhance aerobic endurance training, mainly improving the aerobic capacity. The serum iron of Tian Jiping was promoted quickly. He needs to build up the amount of iron nutrient intake and support the body synthesis. The full iron metabolic indicators were normal, but Zhang Chaoyue and Lin Lin Huan have been seen the lack of the abilities to synthesis iron. So we need to pay attention to iron metabolism-related nutrition intake. In general, iron protein level and the capability to reserve iron have declined. It is recommended to take more iron nutrients, Especially for Shi Ce. (4) Food surveillance After the diet regulation, the indicators for the team's blood fat were within the normal range. Zhang Chaoyue and Wang Zhe should control the high-fat food intake, thus reducing the amount of low-density lipoprotein. (5) Surveillance of immune Indicators The white cell, blood cell classification and immunoglobulin (IgG, IgM, IgA) of the team are all normal, Wang Zhe’s immunoglobulin A and Xu You’s immunoglobulin M are slightly low, we should pay attention to protection. Conclusions  Through the overall monitoring and analysis of the biochemical indexes of the leading athletes of Chinese hearing-impaired table tennis team, The characteristics of biochemical indexes of the high-level hearing-impaired table tennis players are mastered. On the basis of the overall characteristics of the individual, we carried out personalized monitoring and evaluation to give coaches and athletes advice on training, rehabilitation and other aspects related to practice. Biochemical tracking in China's hearing-impaired table tennis team has achieved an excellent application results that have been unanimously recognized by the coaches and athletes. &nbsp

Device-Independent Quantum Key Distribution Based on the Mermin-Peres Magic Square Game

Device-independent quantum key distribution (DIQKD) is information-theoretically secure against adversaries who possess a scalable quantum computer and who have supplied malicious key-establishment systems; however, the DIQKD key rate is currently too low. Consequently, we devise a DIQKD scheme based on the quantum nonlocal Mermin-Peres magic square game: our scheme asymptotically delivers DIQKD against collective attacks, even with noise. Our scheme outperforms DIQKD using the Clauser-Horne-Shimony-Holt game with respect to the number of game rounds, albeit not number of entangled pairs, provided that both state visibility and detection efficiency are high enough.Comment: Numerical errors are corrected while main claims remain unchanged. 6+4 pages. Comments are welcom

A Scorpion Defensin BmKDfsin4 Inhibits Hepatitis B Virus Replication in Vitro

Hepatitis B virus (HBV) infection is a major worldwide health problem which can cause acute and chronic hepatitis and can significantly increase the risk of liver cirrhosis and primary hepatocellular carcinoma (HCC). Nowadays, clinical therapies of HBV infection still mainly rely on nucleotide analogs and interferons, the usage of which is limited by drug-resistant mutation or side effects. Defensins had been reported to effectively inhibit the proliferation of bacteria, fungi, parasites and viruses. Here, we screened the anti-HBV activity of 25 scorpion-derived peptides most recently characterized by our group. Through evaluating anti-HBV activity and cytotoxicity, we found that BmKDfsin4, a scorpion defensin with antibacterial and Kv1.3-blocking activities, has a comparable high inhibitory rate of both HBeAg and HBsAg in HepG2.2.15 culture medium and low cytotoxicity to HepG2.2.15. Then, our experimental results further showed that BmKDfsin4 can dose-dependently decrease the production of HBV DNA and HBV viral proteins in both culture medium and cell lysate. Interestingly, BmKDfsin4 exerted high serum stability. Together, this study indicates that the scorpion defensin BmKDfsin4 also has inhibitory activity against HBV replication along with its antibacterial and potassium ion channel Kv1.3-blocking activities, which shows that BmKDfsin4 is a uniquely multifunctional defensin molecule. Our work also provides a good molecule material which will be used to investigate the link or relationship of its antiviral, antibacterial and ion channel–modulating activities in the future

Superior biological performance and osteoinductive activity of Si-containing bioactive bone regeneration particles for alveolar bone reconstruction

Bone grafting materials for repair of alveolar bone deficits have improved markedly in recent years, increasing the applicability and success of oral implantology. The long-term success rate of dental implant surgery is strongly dependent on the quality and stability of residual bone tissue. Therefore, reconstruction of resorbed alveolar bone is a challenge for clinicians. In the present study, we have developed bioactive bone regeneration particles (BRPs) using amorphous calcium phosphate and 58S bioglass as raw materials. The structural characteristics, biocompatibility, and osteoinductivity of these BRPs were compared to commercially available bovine spongy bone (BSB) without organic components. X-ray diffractometry (XRD) and scanning electron microscopy (SEM) showed that BRPs were composed of β-tricalcium phosphate (β-TCP) and calcium silicate in the form of hexagonal crystals, while BSB was mainly hydroxyapatite (HA) arranged in orderly nano-sized crystals. The viability of human bone marrow mesenchymal stem cells (hBMSCs) cultured in BRP-containing medium was roughly equal to that of hBMSCs in control medium. Moreover, hBMSCs in BRP medium exhibited greater proliferation rates, substrate attachment, alkaline phosphatase (ALP) activity, alizarin red staining intensity, and expression levels of osteogenic-related genes (COL-I, OCN, Runx-2, ALP, BSP) than hBMSCs in BSB medium, indicating the superior osteoinductivity of BRPs. Silicon ions released from BRPs during cell culture were crucial for these enhanced biological properties. BRPs also demonstrated superior osteoconduction and osteoinduction properties for bone defect repair, suggesting promise for alveolar bone repair surgery

Reversing tumor stemness via orally targeted nanoparticles achieves efficient colon cancer treatment

The acquisition of stemness in colorectal cancer (CRC) attributed to the recurrence and metastasis in CRC treatment. Therefore, targeting the stemness of CRC forms a basis for the development of novel therapeutic approaches. However, the pain and systemic side effect from long-term of venipuncture injection remain great challenges to neoplastic treatment. Here, we introduce an oral drug delivery system for sustained release of BMI-1 inhibitor (PTC209) that reverse the stemness of CRC to over-come these obstacles. In this system, nanoparticles modified with hyaluronic acid (HA) showed high-affinity to CD44 / CD168 overexpressed-CRC cells, and efficiently targeted to tumor site in a metastatic orthotropic colon cancer mouse model by oral administration. Significantly, the observed tumor growth inhibition is accompanied by decreased expression of stemness markers in the tumor tissues. Furthermore, HA-NPs-PTC209 also significantly prevented metastasis to the gastrointestinal system, while failing to exhibit acute side effects. In summary, we have developed an orally active, easily synthesized nanomedicine that shows promise for the treatment of colon cancer