2 research outputs found
A Smart DNA Tetrahedron That Isothermally Assembles or Dissociates in Response to the Solution pH Value Changes
This communication reports a DNA
tetrahedron whose self-assembly
is triggered by an acidic environment. The key element is the formation/dissociation
of a short, cytosine (C)-containing, DNA triplex. As the solution
pH value oscillates between 5.0 and 8.0, the DNA triplex will form
and dissociate that, in turn, leads to assembly or disassembly of
the DNA tetrahedron, which has been demonstrated by native polyacrylamide
gel electrophoresis (PAGE). We believe that such environment-responsive
behavior will be important for potential applications of DNA nanocages
such as on-demand drug release
Artificial, Parallel, Left-Handed DNA Helices
This communication reports an engineered DNA architecture.
It contains
multiple domains of half-turn-long, standard B-DNA duplexes. While
each helical domain is right-handed and its two component strands
are antiparallel, the global architecture is left-handed and the two
component DNA strands are oriented parallel to each other