Comment; Eco-Ethica and Environmental Ethics

千葉大学公共研究センター21世紀プログラム「持続可能な福祉社会に向けた公共研究拠点

DBU-Based Protic Ionic Liquids for CO₂ Capture

The applications of the novel anion-functionalized protic ionic liquid (ILs), prepared from superbase 1,8-diazabicyclo[5.4.0]­undec-7-ene (DBU) with imidazole, in the CO₂ absorption have been investigated. It has been detected that this ionic liquid can reversibly capture about 1 mol of CO₂ per mole ionic liquid. In addition, the influence of temperature, pressure, water, and substituent of anions has been uncovered. The capture of CO₂ was significantly affected by the substituents in imidazole-based anion, suggesting that electric-charge distribution in imidazole ring system can play an important role in determining the reaction of ILs with CO₂

Influence of C2–H of Imidazolium-Based Ionic Liquids on the Interaction and Vapor–Liquid Equilibrium of Ethyl Acetate + Ethanol System: [Bmim]BF₄ vs [Bmmim]BF₄

The effect of C2–H of alkylimidazolium tetrafluoroborate ionic liquids on the interaction and vapor–liquid equilibrium (VLE) of the ethyl acetate + ethanol mixture was studied using spectroscopy and the COSMO-RS method. Concentration-dependent ¹H NMR chemical shifts of ethyl acetate + ethanol + [Bmim]­BF₄ or [Bmmim]­BF₄ (<i>x</i>_IL = 0.1 and 0.3) systems show that the interaction between [Bmim]­BF₄ and ethanol is much stronger than that between [Bmmim]­BF₄ and ethanol. Moreover, the experimental and predicted VLE demonstrate that the improvement of relative volatility of ethyl acetate to ethanol by [Bmim]­BF₄ is better than that by [Bmmim]­BF₄. Also, σ-profile obtained from COSMO-RS method indicates that the hydrogen bonding donator ability of [Bmim]⁺ is greater than that of [Bmmim]⁺. Therefore, it can be deduced that the acidic C2–H plays an important role in the interaction differentiation of the ionic liquids and their effect on the VLE of the ethyl acetate + ethanol system, resulting from the interaction of the acidic C2–H with the ethanol that is much stronger than with the ethyl acetate

Regiodivergent Kinetic Resolution of Terminal and Internal <i>rac</i>-Aziridines with Malonates under Dinuclear Schiff Base Catalysis

Regiodivergent parallel kinetic resolution of aziridines with malonates was achieved under dinuclear Schiff base catalysis. The regiodivergent reaction proceeded under catalyst-control irrespective of the substituents on the aziridines, and 2.5–10 mol % of a Y­(OTf)₃/La­(O<i>i</i>Pr)₃/a dinucleating Schiff base = 1:1:1 mixture gave versatile γ-amino acid derivatives in 96 → >99.5% ee. Not only terminal but also internal racemic aziridines reacted smoothly under suitably combined Lewis acid/Brønsted base catalysis

Data File 1: General study of asymmetrical crossed Czerny–Turner spectrometer

Spectrogram values of mercury and CCL4 Originally published in Applied Optics on 20 November 2015 (ao-54-33-9966

Data File 9: High sensitivity and resolution integrated optical system for portable Raman spectrometer

Underlying values of the glass rod spectrogram tested by the independent probe and monochromator and the integrated optical system. Originally published in Applied Optics on 10 September 2016 (ao-55-26-7195

Data File 5: High sensitivity and resolution integrated optical system for portable Raman spectrometer

Underlying values of the CCL4 spectrogram tested by two shortpass dichroic filters. Originally published in Applied Optics on 10 September 2016 (ao-55-26-7195

Calcitonin Inhibits Phenotypic Switching of Aortic Smooth Muscle Cells and Neointimal Hyperplasia through the AMP-Activated Protein Kinase/Mechanistic Target of Rapamycin Pathway

Calcitonin (CT) is a peptide hormone secreted by the parafollicular C cells of the thyroid gland, salmon calcitonin was originally extracted from the hind cheek of salmon. Neointimal hyperplasia refers to the excessive proliferation and migration of vascular smooth muscle cells (VSMCs). In this study, a rat model of restenosis was employed to explore the impact of calcitonin on neointima proliferation. Calcitonin was administered via continuous injections for a duration of 14 days postsurgery, and the expression of proteins associated with proliferation, migration, and phenotypic switching was assessed using the vascular smooth muscle cells. Additionally, metabolomic analyses were conducted to shed light on the mechanisms that underlie the role of calcitonin in the development of cardiovascular disease. In our study, we found that calcitonin possesses the capability to dispute the proliferation, migration, and phenotypic transformation of VSMCs induced by platelet-derived growth factor-BB (PDGF-BB) and 15% fetal bovine serum in vitro. Calcitonin has demonstrated a favorable impact on smooth muscle cells, both in vitro and in vivo. More specifically, it has been observed to mitigate phenotypic switching, proliferation, and migration of these cells. Moreover, calcitonin has been identified as a protective factor against phenotypic switching and the formation of neointima, operating through the AMP-activated protein kinase/mechanistic target of rapamycin (mTOR) pathway