A new inductive debris sensor based on dual-excitation coils and dual-sensing coils for online debris monitoring

Lubricants are of key importance for mechanical processing, and exist in nearly every mechanical system. When the equipment is in operation, debris particles will be generated in mechanical lubricants. The detection of debris particles can indicate the wear degree of machinery components, and provide prognosis warning for the system before the fault occurs. In this work, a novel type of inductive debris sensor consisting of two excitation coils and two sensing coils is proposed for online debris monitoring. The developed sensor was proven to be of high sensitivity through experimental verification. The testing results show that, using the designed sensor, ferrous metal debris with a size of 115 μm and nonferrous metal debris with a size of 313 μm in a pipe with an inner diameter of 12.7 mm can be effectively detected. Moreover, the proposed inductive debris sensor structure has better sensitivity at higher throughput and its design provides a useful insight into the development of high-quality sensors with superior performances

Staphylococcus aureus increases Prostaglandin E2 secretion in cow neutrophils by activating TLR2, TLR4, and NLRP3 inflammasome signaling pathways

IntroductionIn clinical settings, dairy cows are often attacked by pathogenic bacteria after delivery, especially Staphylococcus aureus (S. aureus). Neutrophils have long been regarded as essential for host defense against S. aureus. Prostaglandin E2 (PGE2) can additionally be used as an inflammatory mediator in pathological conditions to promote the repair of inflammatory injuries. However, whether S. aureus can promote the accumulation of PGE2 after the infection of neutrophils in cows and its mechanism remain unclear. Lipoprotein is an important immune bioactive ingredient of S. aureus.MethodsIn this study, the changes in neutrophils were monitored in dairy cows infected with wild-type S. aureus (SA113) and an S. aureus lipoprotein-deficient strain (Δlgt); meanwhile, we established whether pattern recognition receptors mediate this process and whether S. aureus lipoproteins are necessary for causing the release of PGE2 from cow neutrophils.ResultsThe results showed that Δlgt was less effective than SA113 in inducing the production of IL-1β, IL-6, IL-8, IL-10, and PGE2 within neutrophils; furthermore, TLR2, TLR4, and NLRP3 receptors were found to mediate the inducible effect of lipoprotein on the above inflammation mediators and cytokines, which depended on MAPK and Caspase-1 signaling pathways. In addition, TLR2, TLR4, and NLRP3 inhibitors significantly inhibited PGE2 and cytokine secretion, and PGE2 was involved in the interaction of S. aureus and neutrophils in dairy cows, which could be regulated by TLR2, TLR4, and NLRP3 receptors. We also found that S. aureus was more likely to be killed by neutrophils when it lacked lipoprotein and TLR2, TLR4, and NLRP3 were involved, but PGE2 seemed to have no effect.DiscussionTaken together, these results suggest that lipoprotein is a crucial component of S. aureus in inducing cytokine secretion by neutrophils as well as killing within neutrophils, which could be accomplished by the accumulation of PGE2 by activating MAPK and the Caspase-1 signaling pathways through TLR2, TLR4, and NLRP3 receptors. These results will contribute to a better understanding of the interaction between S. aureus and host immune cells in dairy cows

Modes Control of Lamb Wave in Plates Using Meander-Line Electromagnetic Acoustic Transducers

The multimode and dispersion characteristics of Lamb waves make them difficult to apply to nondestructive evaluation. This paper presents a paired configuration of a meander-line coil electromagnetic acoustic transducer (EMAT) to generate a single-mode symmetric and antisymmetric Lamb wave in aluminum plates. In the paired structure, the bias magnetic field of the EMAT that generates symmetric mode Lamb waves is perpendicular to the plate surface, while the bias magnetic field of the EMAT that generates antisymmetric Lamb waves is parallel to the plate surface. The symmetric and antisymmetric exciting forces generated by these two EMATs are consistent with the dispersion equations of single symmetric and antisymmetric Lamb wave modes, respectively. The numerical simulations and experiments verified that the presented paired configurations of meander-line coil EMATs can effectively control the generation of single-mode Lamb waves at low frequencies

The growth and shape of the eyeball and crystalline lens in utero documented by fetal MR imaging

Purpose: To study the growth model, shape, and developmental relationship of lens and eyeball, we used two-dimensional Magnetic Resonance (MR) imaging to investigate gestationally age-related changes in the selected ocular parameters in vivo. Materials and methods: We retrospectively reviewed the MR images from 126 fetuses ranging from 21 to 39 weeks' gestation. Ocular parameters on MR imaging of transverse plane were measured including lens diameter (LD), anteroposterior lens diameter (APLD), lens surface area (LS), globe diameter (GD), anteroposterior globe diameter (APGD), globe surface area (GS). The growth model of each biometric against gestational age (GA), aspect ratio of lens and globe (LD/APLD and GD/APGD), and growing relationship between the ratio of lens and globe surface area (LS/GS) were studied by statistical analysis. Results: The growth model of most biometry for gestational age is logarithmic, except for the diameter of the ocular globe (GD and APGD) showing a quadratic growth pattern. Our study showed that the lens was consistently larger in the transverse than the anteroposterior diameters during 21–39 weeks(P < 0.001). Besides, the ratio of surface area (LS/GS) was not significantly changing with GA(P = 0.4908), while the increase of LS was significantly accorded with that of GS(P < 0.001). Conclusion: The lens shape throughout fetal life may take part in the process, shape changing from vertical ellipsoid, spherical to transversal ellipsoid, based on the logarithmically increased ratio of lens transverse and anteroposterior diameters. In the meanwhile, the aspect ratio of eyeball in late fetal life may imply a gradually spherical shape during gestation. Nomogram data from this study may provide appropriate information about morphological changes in the fetal lens and the synchronous relationship between lens and eyeball

Medical Application of Spirulina platensis

Along with the development of marine biological pharmaceutical research, high-effective and low-toxic drugs and functional foods isolated from marine organisms have become a new field of pharmacy and bromatology. The pharmacological actions, such as anti-inflammation, antioxidation, antitumor, immunological enhancement, and hepatorenal protection of C-phycocyanin (C-PC) from Spirulina platensis, have been reported, and C-PC has important value of development and utilization either as drug or as functional food. There are many researches about the various pharmacological actions and mechanisms of C-PC, but related reports are only to some extent integrated deeply and accurately enough, which put some limitations to the further application of C-PC in medicine. Particularly, with the improvement of living standards and attention to health issues, C-PC being a functional food is preferred by more and more people. C-PC is easy to get, safe, and nontoxic; thus, it has a great potential of research and development as a drug or functional food. Here, the separation and purification, physicochemical properties, physiological and pharmacological activities, safety, and some applications are reviewed to provide relevant basis for the development of natural medicine and applied products

Mechanical properties of the hierarchical honeycombs with stochastic Voronoi sub-structures

The introduction of hierarchy into structures has been credited with changing mechanical properties. In this study, periodically hierarchical honeycomb with irregular sub-structure cells has been designed based on the Voronoi tessellation algorithm. Numerical investigation has been performed to determine the influence of structural hierarchy and irregularity on the in-plane elastic properties. Irregular hierarchical honeycombs can be up to 3 times stiffer than regular hexagonal honeycombs on an equal density basis. Both the stiffness and Poisson's ratio of the hierarchical honeycomb are insensitive to the degree of regularity, and depend on the cell-wall thickness-to-length ratio of the super-structure. Increasing the relative lengths of the super- and sub-structures results in the increment of Young's modulus, whereas Poisson's ratio almost remains constant varying from 1.0 to 0.7

A novel two-level approach to defect detection in braided CFRP using Air-coupled ultrasonic testing

Air-coupled ultrasonic testing and C-scan technique has been increasingly applied to the braided CFRP structures owing to its non-destruction, non-contact and high visualization characteristics. Due to the noise, structural vibration, and airflow in the process of detection, the accuracy of defect identification is easily deteriorated. To address this issue and further determine the relationship between the ultrasonic acoustical pressure attenuation and structural parameters, a novel two-level identification method based on the modified two-dimensional variational mode decomposition (2D-VMD) has been proposed. In the first level, C-scan images have been sparsely decomposed into ensembles of modes by 2D-VMD method. Then, the modes have been screened by mutual information method to realize the reconstruction of new image in the second level. Experimental results have shown that the proposed method has the good ability to identify defects with a minimum detectable diameter of 1~2mm. It has been noted that the ultrasonic acoustical pressure attenuation has become remarkably higher in the twill weave CFRP than the plain weave CFRP and the ratio of pressure attenuation between two weave types of CFRP has decreased with the defect depth increase. Meanwhile, shadows around defects in C-scan images have been suppressed to a great extent. It has been demonstrated that the capability of denoising has enabled the developed method with the accurate detection in terms of the shape, size, depth and weave type. With these advantages, the proposed method has provided valuable insights into the development of an effective method for defect detection of braided CFRP structures

Enhanced tunable fracture properties of the high stiffness hierarchical honeycombs with stochastic Voronoi substructures

For multifunctional optimization design of honeycomb structures, the high stiffness hierarchical honeycombs with stochastic Voronoi substructures (HHSVS) are proposed by substituting cell walls of the regular hexagonal honeycombs (ORHH) with Voronoi honeycomb lattices of equal mass. In this study, the tunable linear elastic fracture properties of the HHSVS are investigated by finite element analysis. Results demonstrate that size effect on fracture toughness of the HHSVS is noticeable and a brittleness number is suggested to determine it. At the same time, compared with the ORHH and conventional Voronoi honeycombs of equal mass/density, the in-plane fracture toughness of the HHSVS could be more than 2 times larger and regardless of the cell regularity and hierarchical parameters, fracture toughness of the HHSVS exhibits a weaker quadratic dependence on the relative density and is the highest. As a whole, the HHSVS exhibit the combined properties of tunable Poisson’s ratio, higher stiffness, enhanced tunable fracture toughness, lower imperfection sensitivity and better structural-acoustic performance etc. The research provides a novel strategy for the multifunctional optimization design of the honeycombs structures widely used in the engineering fields. Keywords: Hierarchical honeycombs with stochastic Voronoi substructures (HHSVS), Tunable fracture toughness, Size effect, T-stres

Assessment and Spatial-Temporal Evolution Analysis of Land Use Conflict within Urban Spatial Zoning: Case of the Su-Xi-Chang Region

As China rapidly urbanizes, land resources tend to deplete. This paper aims to identify and propose a resolution of land use conflicts to promote sustainable land use and coordinate the interaction between humans and the environment in urban areas. The methodology of land use conflict assessment within spatial zoning of the Su–Xi–Chang region was evaluated. Taking into consideration the intensity of human activities and the background condition of the natural environment, we divided the study area into a few regions. Furthermore, we developed a methodology by calculating landscape complexity, fragility, and stability based on spatial zoning so as to derive the spatio-temporal characteristics of the land use conflict index (LUCI) in the Su–Xi–Chang region. The results indicate the following: (1) According to the urban spatial attribute index (USAI) statistics, we delineate the core, fringe, and suburban zones of the Su–Xi–Chang region, which accounted for 9.61%, 11.06%, and 79.33% of urban agglomerations respectively; (2) from 1990 to 2018, the fragility index (FI) and LUCI showed S-shaped curves, while the complexity (CI) and the stability indices (SI) exhibited minor fluctuations in the fringe and suburb zones; and (3) intensive and severe conflict is concentrated in core areas due to quite intense human activities and in fringe areas due to an increased interaction between humans and land, while moderate conflict is mainly found in rural and suburban areas that pose as a natural environmental space. The results can serve as a theoretical framework for an effective identification of the LUCI in an urban agglomeration and coordination of the optimal allocation of regional land resources