Instanton Effects in QCD Sum Rules for the 0++0^{++} Hybrid

In this paper, we study instanton contributions to the correlator of the hybrid current $g\bar q \sigma_{\mu\nu}G^a_{\nu\mu}T^a q$. These contributions are then included in a QCD sum-rule analysis of the isoscalar $0^{++}$ hybrid mass. We find a mass at 1.83 GeV for the $(\bar uug+\bar ddg)/\sqrt{2}$ hybrid. However, for the $\bar ssg$ hybrid, we find the sum rules are unstable. We also study non-zero width effects, which affect the mass prediction. The mixing effects between these two states are studied and we find QCD sum rules support the existence of a flavor singlet hybrid with mass at around 1.9 GeV. Finally, we study the mixing effects between hybrid and glueball currents. The mixing between the $(\bar uug+\bar ddg)/\sqrt{2}$($\bar ssg$) and the glueball causes two states, one in the region 1.4-1.8 GeV(1.4-2.2 GeV), and the other in the range 1.8-2.2 GeV(2.2-2.6 GeV).Comment: 12 pages, revised versio

Effects of Different Scraping Techniques on Body Surface Blood Perfusion Volume and Local Skin Temperature of Healthy Subjects

ObjectiveTo study the mechanism and effects of different scraping techniques on body surface blood perfusion volume and local skin temperature of healthy subjects and to provide a baseline for microcirculation and energy metabolism for the evaluation of the therapeutic effects of scraping.MethodsChanges of the local blood perfusion volume and skin temperature of healthy subjects before and after applying different scraping techniques were observed with a laser Doppler imager combined with an infrared thermographic device and the resulting data was analyzed with imaging and processing software for statistical analysis.ResultsLocal blood perfusion volume and skin temperature all increased after both reinforcing and reducing scraping techniques. The value of blood flow 60 and 90 min after the reducing technique was significantly higher than that after the reinforcing technique (P<0.01), while the skin temperature increased after both techniques but was not significantly different between the two (P>0.05)ConclusionScraping can significantly improve the local blood perfusion volume, increase skin temperature and promote local blood circulation and metabolism of tissues

A Comparative Analysis of Gene-Expression Data of Multiple Cancer Types

A comparative study of public gene-expression data of seven types of cancers (breast, colon, kidney, lung, pancreatic, prostate and stomach cancers) was conducted with the aim of deriving marker genes, along with associated pathways, that are either common to multiple types of cancers or specific to individual cancers. The analysis results indicate that (a) each of the seven cancer types can be distinguished from its corresponding control tissue based on the expression patterns of a small number of genes, e.g., 2, 3 or 4; (b) the expression patterns of some genes can distinguish multiple cancer types from their corresponding control tissues, potentially serving as general markers for all or some groups of cancers; (c) the proteins encoded by some of these genes are predicted to be blood secretory, thus providing potential cancer markers in blood; (d) the numbers of differentially expressed genes across different cancer types in comparison with their control tissues correlate well with the five-year survival rates associated with the individual cancers; and (e) some metabolic and signaling pathways are abnormally activated or deactivated across all cancer types, while other pathways are more specific to certain cancers or groups of cancers. The novel findings of this study offer considerable insight into these seven cancer types and have the potential to provide exciting new directions for diagnostic and therapeutic development

A miniaturized sandwich immunoassay platform for the detection of protein-protein interactions

<p>Abstract</p> <p>Background</p> <p>Analysis of protein-protein interactions (PPIs) is a valuable approach for the characterization of huge networks of protein complexes or proteins of unknown function. Co-immunoprecipitation (coIP) using affinity resins coupled to protein A/G is the most widely used method for PPI detection. However, this traditional large scale resin-based coIP is too laborious and time consuming. To overcome this problem, we developed a miniaturized sandwich immunoassay platform (MSIP) by combining antibody array technology and coIP methods.</p> <p>Results</p> <p>Based on anti-FLAG antibody spotted aldehyde slides, MSIP enables simple, rapid and large scale detection of PPIs by fluorescent labeling anti-myc antibody. By analyzing well-known interacting and non-interacting protein pairs, MSIP was demonstrated to be highly accurate and reproducible. Compared to traditional resin-based coIP, MSIP results in higher sensitivity and enhanced throughput, with the additional benefit of digital read-outs. In addition, MSIP was shown to be a highly useful validation platform to confirm PPI candidates that have been identified from yeast two hybrid systems.</p> <p>Conclusions</p> <p>In conclusion, MSIP is proved to be a simple, cost-saving and highly efficient technique for the comprehensive study of PPIs.</p

Secondary cutaneous Epstein-Barr virus-associated diffuse large B-cell lymphoma in a patient with angioimmunoblastic T-cell lymphoma: a case report and review of literature

Only a few cases of extranodal Epstein-Barr virus (EBV)-associated B-cell lymphomas arising from patients with angioimmunoblastic T-cell lymphoma (AITL) have been described. We report a case of AITL of which secondary cutaneous EBV-associated diffuse large B-cell lymphoma (DLBCL) developed after the initial diagnosis of AITL. A 65-year-old Chinese male patient was diagnosed as AITL based on typical histological and immunohistochemical characteristics in biopsy of the enlarged right inguinal lymph nodes. The patient initially received 6 cycles of chemotherapy with CHOP regimen (cyclophosphamide, vincristine, adriamycin, prednisone), but his symptoms did not disappear. Nineteen months after initial diagnosis of AITL, the patient was hospitalized again because of multiple plaques and nodules on the skin. The skin biopsy was performed, but this time the tumor was composed of large, polymorphous population of lymphocytes with CD20 and CD79a positive on immunohistochemical staining. The tumor cells were strong positive for EBER by in situ hybridization. The findings of skin biopsy were compatible with EBV-associated DLBCL. CHOP-R chemotherapy (cyclophosphamide, doxorubicin, vincristine, prednisone and rituximab) was then administered, resulting in partial response of the disease with pancytopenia and suppression of cellular immunity. To our knowledge, this is the first case of cutaneous EBV-associated DLBCL originated from AITL in Chinese pepole. We suggest the patients with AITL should perform lymph node and skin biopsies regularly in the course of the disease to detect the progression of secondary lymphomas

Social network site use and materialistic values: The roles of self-control and self-acceptance

Background While prior studies have established a close association between the use of social network sites (SNSs) and materialistic values, there is limited understanding of the mediating and moderating mechanisms related to important self-related processes, such as self-control and self-acceptance. This paper explores whether and how these factors play a role in comprehending online behavior. One could state that frequent SNS use may pose a risk of virtual addiction, may be related to decreased self-control capacity, and may increase attention to material information on SNS, thereby making it more likely that users affiliate with behaviors associated with materialistic values. In contrast, self-acceptance, as a stable self-process indicating a genuine alignment with one’s true self and the ability to make decisions based on inner needs, may be related with reduced engagement in complex information on SNSs. Consequently, this could serve as a buffer against excessive SNS use and its potential associations with issues of self-control and materialistic values. Methods A total of 706 Chinese college students were surveyed in a cross-sectional study. They completed self-report questionnaires including the WeChat use intensity scale, the Material Value Scale, the Trait Self-control Scale, and the Self-acceptance Questionnaire. A moderated mediation model was examined to test predictions. Results SNS use intensity was positively associated with materialistic values, and self-control partially mediated this association. That is, higher intensity SNS users are more likely lower in self-control, which relates to stronger materialistic values. In addition, the indirect effect through self-control was moderated by self-acceptance, such that this indirect effect was significant only for individuals with low levels of self-acceptance. Conclusions This study reveals that self-acceptance may be a protective factor that helps to mitigate excessive SNS use and its potential effects on self-control and materialistic values. It further suggests that psychological interventions targeting the enhancement of self-acceptance and self-control could hold promise in alleviating the negative association between SNS use and materialistic values