Basal information of patient with different <i>TP53</i> codon72 SNP.

<p>Basal information of patient with different <i>TP53</i> codon72 SNP.</p

Association of <i>TP53</i> codon72 polymorphism and female infertility.

<p>Association of <i>TP53</i> codon72 polymorphism and female infertility.</p

Influence of <i>TP</i>53 Codon 72 Polymorphism Alone or in Combination with <i>HDM</i>2 SNP309 on Human Infertility and IVF Outcome

<div><p>To evaluate the association of the <i>TP</i>53 codon 72 (rs 1042522) alone or in combination with <i>HDM</i>2 SNP309 (rs 2279744) polymorphisms with human infertility and IVF outcome, we collected 1450 infertility women undergoing their first controlled ovarian stimulation for IVF treatment and 250 fertile controls in the case-control study. Frequencies, distribution, interaction of genes, and correlation with infertility and IVF outcome of clinical pregnancy were analyzed. We found a statistically significant association between <i>TP</i>53 codon 72 polymorphism and IVF outcome (52.10% vs. 47.40%, OR = 0.83, 95%CI:0.71–0.96, p = 0.01). No significant difference was shown between <i>TP</i>53 codon 72, <i>HDM</i>2 SNP309 polymorphisms, human infertility, and between <b>the combination of two genes polymorphisms</b> and the clinical pregnancy outcome of IVF. The data support C allele as a protective factor for IVF pregnancy outcome. Further researches should be focused on the mechanism of these associations.</p></div

Basic information of female patients with different <i>HDM</i>2 SNP309.

<p>Basic information of female patients with different <i>HDM</i>2 SNP309.</p

Association of <i>HDM</i>2 SNP309 polymorphism and female infertility.

<p>Association of <i>HDM</i>2 SNP309 polymorphism and female infertility.</p

Association of female <i>HDM</i>2 SNP309 and IVF outcome.

<p>Association of female <i>HDM</i>2 SNP309 and IVF outcome.</p

Conjoint analysis between pregnancy outcome and female polymorphism of <i>TP53</i> codon72 and <i>HDM</i>2 SNP309.

<p>Conjoint analysis between pregnancy outcome and female polymorphism of <i>TP53</i> codon72 and <i>HDM</i>2 SNP309.</p

Frequencies of female <i>TP53</i> codon72 polymorphism among women with different IVF outcome.

<p>Frequencies of female <i>TP53</i> codon72 polymorphism among women with different IVF outcome.</p

Additional file 1: of Enabling multiplexed testing of pooled donor cells through whole-genome sequencing

Note S1–2. working example of the method and comparison of the method against PRISM. (PDF 278 kb

Additional file 2 of Enabling multiplexed testing of pooled donor cells through whole-genome sequencing

Table S1–6. all supplementary tables. (XLSX 638 kb