Microplastics in Surface Waters and Sediments from Guangdong Coastal Areas, South China

Microplastic is an emerging global pollutant that have attracted a great deal of attention from researchers and the public. Guangdong Province has a large population and a relatively well-developed economy, but lacks a modern pollution control system. Guangdong has a long coastline with varying levels of pollution, and little research has been conducted on microplastics. Therefore, we investigated the level of microplastic pollution in coastal areas of Guangdong Province, and the abundance of microplastics in surface waters and sediments at 13 sampling sites. The abundance of microplastics in surface water and sediment samples ranged from 850 to 3500 items/L and 433.3 to 4166.3 items/kg, respectively. Fiber is the main type of microplastics in both surface water and sediment. The sampled microplastics were typically transparent. Raman results show that the surface water sample mainly includes rayon (38.2%), polyethylene terephthalate (16.4%), and ethylene/vinyl acetate copolymer (12.7%). This study used the pollution load index method to evaluate the pollution risk of microplastics along the coast of Guangdong, and provided the basis for the formulation of environmental policy

Early Pulmonary Fibrosis-like Changes in the Setting of Heat Exposure: DNA Damage and Cell Senescence

It is well known that extreme heat events happen frequently due to climate change. However, studies examining the direct health impacts of increased temperature and heat waves are lacking. Previous reports revealed that heatstroke induced acute lung injury and pulmonary dysfunction. This study aimed to investigate whether heat exposure induced lung fibrosis and to explore the underlying mechanisms. Male C57BL/6 mice were exposed to an ambient temperature of 39.5 ± 0.5 °C until their core temperature reached the maximum or heat exhaustion state. Lung fibrosis was observed in the lungs of heat-exposed mice, with extensive collagen deposition and the elevated expression of fibrosis molecules, including transforming growth factor-β1 (TGF-β1) and Fibronectin (Fn1) (p p p p < 0.05). In summary, we reported a new finding that heat exposure contributed to the development of early pulmonary fibrosis-like changes through the DNA damage-activated cGAS–STING pathway followed by cellular senescence

Mechanistic Insights into 1,2-bis(2,4,6-tribromophenoxy)ethane-Induced Male Reproductive Toxicity in Zebrafish

The novel brominated flame retardant, 1,2-bis(2,4,6-tribromophenoxy)ethane (BTBPE), has increasingly been detected in environmental and biota samples. However, limited information is available regarding its toxicity, especially at environmentally relevant concentrations. In the present study, adult male zebrafish were exposed to varying concentrations of BTBPE (0, 0.01, 0.1, 1, and 10 μg/L) for 28 days. The results demonstrated underperformance in mating behavior and reproductive success of male zebrafish when paired with unexposed females. Additionally, a decline in sperm quality was confirmed in BTBPE-exposed male zebrafish, characterized by decreased total motility, decreased progressive motility, and increased morphological malformations. To elucidate the underlying mechanism, an integrated proteomic and phosphoproteomic analysis was performed, revealing a predominant impact on mitochondrial functions at the protein level and a universal response across different cellular compartments at the phosphorylation level. Ultrastructural damage, increased expression of apoptosis-inducing factor, and disordered respiratory chain confirmed the involvement of mitochondrial impairment in zebrafish testes. These findings not only provide valuable insights for future evaluations of the potential risks posed by BTBPE and similar chemicals but also underscore the need for further research into the impact of mitochondrial dysfunction on reproductive health