1,419 research outputs found
Little String Amplitudes (and the Unreasonable Effectiveness of 6D SYM)
We study tree level scattering amplitudes of four massless states in the
double scaled little string theory, and compare them to perturbative loop
amplitudes in six-dimensional super-Yang-Mills theory. The little string
amplitudes are computed from correlators in the cigar coset CFT and in N=2
minimal models. The results are expressed in terms of integrals of conformal
blocks and evaluated numerically in the alpha' expansion. We find striking
agreements with up to 2-loop scattering amplitudes of massless gluons in 6D
SU(k) SYM at a Z_k invariant point on the Coulomb branch. We comment on the
issue of UV divergence at higher loop orders in the gauge theory and discuss
the implication of our results.Comment: 58 pages, 5 figures, 3 tables, comments added, references adde
Topological Defect Lines and Renormalization Group Flows in Two Dimensions
We consider topological defect lines (TDLs) in two-dimensional conformal
field theories. Generalizing and encompassing both global symmetries and
Verlinde lines, TDLs together with their attached defect operators provide
models of fusion categories without braiding. We study the crossing relations
of TDLs, discuss their relation to the 't Hooft anomaly, and use them to
constrain renormalization group flows to either conformal critical points or
topological quantum field theories (TQFTs). We show that if certain
non-invertible TDLs are preserved along a RG flow, then the vacuum cannot be a
non-degenerate gapped state. For various massive flows, we determine the
infrared TQFTs completely from the consideration of TDLs together with modular
invariance.Comment: 101 pages, 63 figures, 2 tables; v3: minor changes, added footnotes
and references, published versio
Deformations with maximal supersymmetries part 2: off-shell formulation
Continuing our exploration of maximally supersymmetric gauge theories (MSYM) deformed by higher dimensional operators, in this paper we consider an off-shell approach based on pure spinor superspace and focus on constructing supersymmetric deformations beyond the first order. In particular, we give a construction of the Batalin-Vilkovisky action of an all-order non-Abelian Born-Infeld deformation of MSYM in the non-minimal pure spinor formalism. We also discuss subtleties in the integration over the pure spinor superspace and the relevance of Berkovits-Nekrasov regularization.Kavli Institute for Theoretical Physics (Graduate Fellowship)Alfred P. Sloan Foundation. FellowshipSimons Foundation (Simons Investigator Award)National Science Foundation (U.S.) (Award PHY-0847457
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Assessing the validity of SafeGraph data for visitor monitoring in Yellowstone National Park
Monitoring visitor demographics and temporal visitation patterns will help park managers allocate resources, develop infrastructure, and predict the demands of visitors. Previous studies have only validated temporal visitation patterns with big data and traditional survey data, while research on validation national park visitor demographics using mobile data is scant.
This study compares SafeGraph data (a type of mobile Location-based Service data) and survey/count data, assessing visitor demographics and temporal visitation patterns in Yellowstone National Park. The comparison between two data sources suggests that SafeGraph data can serve as an additional and complementary source of information to traditional visitor use study/count data. However, biases of SafeGraph data, such as data at an aggregation level and data only in the United States, resulting in differences compared to traditional survey/count data. This study contributes to understanding visitors in national parks by validating a new data source
CCN2 Enhances Resistance to Cisplatin-Mediating Cell Apoptosis in Human Osteosarcoma
Osteosarcoma (OS) is the most common form of malignant bone tumor and is an aggressive malignant neoplasm exhibiting osteoblastic differentiation. Cisplatin is one of the most efficacious antitumor drugs for osteosarcoma patients. However, treatment failures are common due to the development of chemoresistance. CCN2 (also known as CTGF), is a secreted protein that binds to integrins, modulates the invasive behavior of certain human cancer cells. However, the effect of CCN2 in cisplatin-mediated chemotherapy is still unknown. Here, we found that CCN2 was upregulated in human osteosarcoma cells after treatment with cisplatin. Moreover, overexpression of CCN2 increased the resistance to cisplatin-mediated cell apoptosis. In contrast, reduction of CCN2 by CCN2 shRNA promoted the chemotherapeutic effect of cisplatin. We also found that CCN2 provided resistance to cisplatin-induced apoptosis through upregulation of Bcl-xL and survivin. Knockdown of Bcl-xL or survivin removed the CCN2-mediated resistance to apoptosis induced by cisplatin. On the other hand, CCN2 also promoted FAK, MEK, and ERK survival signaling pathways to enhance tumor survival during cisplatin treatment. In a mouse xenograft model, overexpression of CCN2 promoted resistance to cisplatin. However, knockdown of CCN2 increased the therapeutic effect of cisplatin. Therefore, our data suggest that CCN2 might be a critical oncogene of human osteosarcoma for cisplatin-resistance and supported osteosarcoma cell growth in vivo and in vitro
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