Table_1_Prediction of bronchodilation test in adults with chronic cough suspected of cough variant asthma.docx

BackgroundMany patients with cough variant asthma (CVA) are underdiagnosed and undertreated due to the atypical symptoms, low diagnostic sensitivity of bronchodilator response (BDR), and limited application of bronchial challenge test.ObjectiveTo investigate whether airway reversibility in BDR can predict CVA diagnosis in patients with chronic cough and negative BDR.MethodsThis open-label, prospective cohort study included patients with chronic cough, nearly normal chest CT scan, and negative BDR results. Inhaled corticosteroids and long-acting β2 agonists were given for 4 weeks. The confirmed diagnosis of CVA was defined as improved symptoms and an increase of forced expiratory volume in 1 s (FEV1) by >12% and >200 mL after 4 weeks of treatment.ResultsOf 155 patients recruited, 140 completed the study. Patients in the CVA positive diagnosis group had greater absolute (Δ) and percent (Δ%) improvements in FEV1 and forced expiratory flows (FEFs), and higher fractional exhaled nitric oxide (FENO) than in the CVA negative diagnosis group. The area under the receiver operating characteristic curves (AUCs) of ΔFEV1%, FEF25–75%pred (percentage of predicted forced expiratory flow at 25% to 75%) and FENO for CVA positive diagnosis was 0.825, 0.714, and 0.637, with cutoff values of 5.90%, 61.99% and 41.50 ppb, respectively. A joint model of ΔFEV1% combined with FEF25–75%pred or FENO increased the AUC to 0.848 and 0.847, respectively.ConclusionΔFEV1% in BDR can predict a CVA diagnosis and response to anti-asthma treatment in patients with chronic cough and negative BDR.Clinical trial registration[http://www.chictr.org.cn/index.aspx], identifier [ChiCTR2000029065].</p

Image_1_Prediction of bronchodilation test in adults with chronic cough suspected of cough variant asthma.JPEG

BackgroundMany patients with cough variant asthma (CVA) are underdiagnosed and undertreated due to the atypical symptoms, low diagnostic sensitivity of bronchodilator response (BDR), and limited application of bronchial challenge test.ObjectiveTo investigate whether airway reversibility in BDR can predict CVA diagnosis in patients with chronic cough and negative BDR.MethodsThis open-label, prospective cohort study included patients with chronic cough, nearly normal chest CT scan, and negative BDR results. Inhaled corticosteroids and long-acting β2 agonists were given for 4 weeks. The confirmed diagnosis of CVA was defined as improved symptoms and an increase of forced expiratory volume in 1 s (FEV1) by >12% and >200 mL after 4 weeks of treatment.ResultsOf 155 patients recruited, 140 completed the study. Patients in the CVA positive diagnosis group had greater absolute (Δ) and percent (Δ%) improvements in FEV1 and forced expiratory flows (FEFs), and higher fractional exhaled nitric oxide (FENO) than in the CVA negative diagnosis group. The area under the receiver operating characteristic curves (AUCs) of ΔFEV1%, FEF25–75%pred (percentage of predicted forced expiratory flow at 25% to 75%) and FENO for CVA positive diagnosis was 0.825, 0.714, and 0.637, with cutoff values of 5.90%, 61.99% and 41.50 ppb, respectively. A joint model of ΔFEV1% combined with FEF25–75%pred or FENO increased the AUC to 0.848 and 0.847, respectively.ConclusionΔFEV1% in BDR can predict a CVA diagnosis and response to anti-asthma treatment in patients with chronic cough and negative BDR.Clinical trial registration[http://www.chictr.org.cn/index.aspx], identifier [ChiCTR2000029065].</p

Image_2_Prediction of bronchodilation test in adults with chronic cough suspected of cough variant asthma.JPEG

BackgroundMany patients with cough variant asthma (CVA) are underdiagnosed and undertreated due to the atypical symptoms, low diagnostic sensitivity of bronchodilator response (BDR), and limited application of bronchial challenge test.ObjectiveTo investigate whether airway reversibility in BDR can predict CVA diagnosis in patients with chronic cough and negative BDR.MethodsThis open-label, prospective cohort study included patients with chronic cough, nearly normal chest CT scan, and negative BDR results. Inhaled corticosteroids and long-acting β2 agonists were given for 4 weeks. The confirmed diagnosis of CVA was defined as improved symptoms and an increase of forced expiratory volume in 1 s (FEV1) by >12% and >200 mL after 4 weeks of treatment.ResultsOf 155 patients recruited, 140 completed the study. Patients in the CVA positive diagnosis group had greater absolute (Δ) and percent (Δ%) improvements in FEV1 and forced expiratory flows (FEFs), and higher fractional exhaled nitric oxide (FENO) than in the CVA negative diagnosis group. The area under the receiver operating characteristic curves (AUCs) of ΔFEV1%, FEF25–75%pred (percentage of predicted forced expiratory flow at 25% to 75%) and FENO for CVA positive diagnosis was 0.825, 0.714, and 0.637, with cutoff values of 5.90%, 61.99% and 41.50 ppb, respectively. A joint model of ΔFEV1% combined with FEF25–75%pred or FENO increased the AUC to 0.848 and 0.847, respectively.ConclusionΔFEV1% in BDR can predict a CVA diagnosis and response to anti-asthma treatment in patients with chronic cough and negative BDR.Clinical trial registration[http://www.chictr.org.cn/index.aspx], identifier [ChiCTR2000029065].</p

sj-pdf-2-aje-10.1177_10982140211071017 - Supplemental material for Program Value-Added: A Feasible Method for Providing Evidence on the Effectiveness of Multiple Programs Implemented Simultaneously in Schools

Supplemental material, sj-pdf-2-aje-10.1177_10982140211071017 for Program Value-Added: A Feasible Method for Providing Evidence on the Effectiveness of Multiple Programs Implemented Simultaneously in Schools by Robert Shand, Stephen M. Leach, Fiona M. Hollands, Florence Chang, Yilin Pan, Bo Yan, Dena Dossett, Samreen Nayyer-Qureshi, Yixin Wang and Laura Head in American Journal of Evaluation</p

sj-pdf-3-aje-10.1177_10982140211071017 - Supplemental material for Program Value-Added: A Feasible Method for Providing Evidence on the Effectiveness of Multiple Programs Implemented Simultaneously in Schools

Supplemental material, sj-pdf-3-aje-10.1177_10982140211071017 for Program Value-Added: A Feasible Method for Providing Evidence on the Effectiveness of Multiple Programs Implemented Simultaneously in Schools by Robert Shand, Stephen M. Leach, Fiona M. Hollands, Florence Chang, Yilin Pan, Bo Yan, Dena Dossett, Samreen Nayyer-Qureshi, Yixin Wang and Laura Head in American Journal of Evaluation</p

sj-pdf-6-aje-10.1177_10982140211071017 - Supplemental material for Program Value-Added: A Feasible Method for Providing Evidence on the Effectiveness of Multiple Programs Implemented Simultaneously in Schools

Supplemental material, sj-pdf-6-aje-10.1177_10982140211071017 for Program Value-Added: A Feasible Method for Providing Evidence on the Effectiveness of Multiple Programs Implemented Simultaneously in Schools by Robert Shand, Stephen M. Leach, Fiona M. Hollands, Florence Chang, Yilin Pan, Bo Yan, Dena Dossett, Samreen Nayyer-Qureshi, Yixin Wang and Laura Head in American Journal of Evaluation</p

sj-pdf-4-aje-10.1177_10982140211071017 - Supplemental material for Program Value-Added: A Feasible Method for Providing Evidence on the Effectiveness of Multiple Programs Implemented Simultaneously in Schools

Supplemental material, sj-pdf-4-aje-10.1177_10982140211071017 for Program Value-Added: A Feasible Method for Providing Evidence on the Effectiveness of Multiple Programs Implemented Simultaneously in Schools by Robert Shand, Stephen M. Leach, Fiona M. Hollands, Florence Chang, Yilin Pan, Bo Yan, Dena Dossett, Samreen Nayyer-Qureshi, Yixin Wang and Laura Head in American Journal of Evaluation</p

sj-docx-7-aje-10.1177_10982140211071017 - Supplemental material for Program Value-Added: A Feasible Method for Providing Evidence on the Effectiveness of Multiple Programs Implemented Simultaneously in Schools

Supplemental material, sj-docx-7-aje-10.1177_10982140211071017 for Program Value-Added: A Feasible Method for Providing Evidence on the Effectiveness of Multiple Programs Implemented Simultaneously in Schools by Robert Shand, Stephen M. Leach, Fiona M. Hollands, Florence Chang, Yilin Pan, Bo Yan, Dena Dossett, Samreen Nayyer-Qureshi, Yixin Wang and Laura Head in American Journal of Evaluation</p

sj-pdf-1-aje-10.1177_10982140211071017 - Supplemental material for Program Value-Added: A Feasible Method for Providing Evidence on the Effectiveness of Multiple Programs Implemented Simultaneously in Schools

Supplemental material, sj-pdf-1-aje-10.1177_10982140211071017 for Program Value-Added: A Feasible Method for Providing Evidence on the Effectiveness of Multiple Programs Implemented Simultaneously in Schools by Robert Shand, Stephen M. Leach, Fiona M. Hollands, Florence Chang, Yilin Pan, Bo Yan, Dena Dossett, Samreen Nayyer-Qureshi, Yixin Wang and Laura Head in American Journal of Evaluation</p

sj-pdf-5-aje-10.1177_10982140211071017 - Supplemental material for Program Value-Added: A Feasible Method for Providing Evidence on the Effectiveness of Multiple Programs Implemented Simultaneously in Schools

Supplemental material, sj-pdf-5-aje-10.1177_10982140211071017 for Program Value-Added: A Feasible Method for Providing Evidence on the Effectiveness of Multiple Programs Implemented Simultaneously in Schools by Robert Shand, Stephen M. Leach, Fiona M. Hollands, Florence Chang, Yilin Pan, Bo Yan, Dena Dossett, Samreen Nayyer-Qureshi, Yixin Wang and Laura Head in American Journal of Evaluation</p