The list of lncRNAs independently associated with overall survival of gastric cancer.

<p>The list of lncRNAs independently associated with overall survival of gastric cancer.</p

LncRNAs associated with subtype.

<p>(a) Volcano plot of the differential expression analysis of lncRNA between the two subtypes. (b) The box plot showing differential expression of PGM5-AS1 among diffuse subtype, intestinal subtype and normal tissue. (c) The box plot showing differential expression of UCA1 among diffuse subtype, intestinal subtype and normal tissue.</p

Flow chart of identification of lncRNAs associated with prognosis.

<p>Flow chart of identification of lncRNAs associated with prognosis.</p

LncRNAs in regions of somatic copy number alterations.

<p>(a) Chromosomal view of amplification and deletion peaks of gastric cancer. (b) Histogram of correlations between copy number and RNA expression level. (c) The correlation between copy number and expression level of PVT1. (d) The correlation between copy number and expression level of KB-1208A12.3.</p

Co-expression network analysis.

<p>(a) Gene clustering and module identification. (b) LncRNAs distribution in the different modules. (c) Pathway analysis of genes in green module. (d) Pathway analysis of genes in blue module.</p

Differentially expressed lncRNAs in gastric cancer.

<p>(a) Volcano plot of the differential expression analysis of lncRNAs. (b) Pie charts showing the number of differentially expressed lncRNAs in each category. (c) Heatmap of unsupervised hierarchical clustering of differentially expressed lncRNAs in all samples.</p

fox eye

fox nlittle ring (around the moon)little ring (around the moon)Used I and SupUsed INot use

Schema of effects on respiration.

<p>CDCA, DCA, LCA, CA and FXR agonist GW4064 influence respiration via FXR represent by changes in respiratory cycle, inspiratory time, expiratory time and integral amplitude. To confirm the involvement of FXR, the FXR inhibitor Z-guggulsterone is co-administered with the above bile acids and GW4064, completely reversing their effects on respiration.</p

Effects of GW4064 (3 µM) and the FXR blocker Z-guggulsterone (20 µM) on RRDA recorded from hypoglossal nerves in neonatal rat brainstem medulla oblongata slice.

<p>Effects of GW4064 (3 µM) and the FXR blocker Z-guggulsterone (20 µM) on RRDA recorded from hypoglossal nerves in neonatal rat brainstem medulla oblongata slice.</p

Effects of GW4064 (3 µM) and the FXR blocker Z-guggulsterone (20 µM) on RRDA recorded from hypoglossal nerves (A, B, C).

<p>The last figure specifically shows effects on TI(s) of RRDA (D). (n = 6 independent assays. *P<0.05, **P<0.01 vs. control. RC, respiratory cycle; TI, inspiratory time; TE, expiratory time; IA, integral amplitude.)</p