1 research outputs found
Intrinsic Strain-Mediated Ultrathin Ceria Nanoantioxidant
Metal
oxide nanozymes have emerged as the most efficient
and promising
candidates to mimic antioxidant enzymes for treatment of oxidative
stress-mediated pathophysiological disorders, but the current effectiveness
is unsatisfactory due to insufficient catalytic performance. Here,
we report for the first time an intrinsic strain-mediated ultrathin
ceria nanoantioxidant. Surface strain in ceria with variable thicknesses
and coordinatively unsaturated Ce sites was investigated by theoretical
calculation analysis and then was validated by preparing ∼1.2
nm ultrathin nanoplates with ∼3.0% tensile strain in plane/∼10.0%
tensile strain out of plane. Compared with nanocubes, surface strain
in ultrathin nanoplates could enhance the covalency of the Ce–O
bond, leading to increasing superoxide dismutase (SOD)-mimetic activity
by ∼2.6-fold (1533 U/mg, in close proximity to that of natural
SOD) and total antioxidant activity by ∼2.5-fold. As a proof
of concept, intrinsic strain-mediated ultrathin ceria nanoplates could
boost antioxidation for improved ischemic stroke treatment in vivo, significantly better than edaravone, a commonly
used clinical drug