Phylogenetic tree constructed by alignment of consensus sequence of the isolates in each subgroup, using the neighbor- joining method and evaluated using the interior branch test method with Mega 4 software

Percent bootstrap support is indicated at each node. Avian HEV strain is included as outgroup.<p><b>Copyright information:</b></p><p>Taken from "Prevalence of four different subgenotypes of genotype 4 hepatitis E virus among swine in the Shanghai area of China"</p><p>http://www.actavetscand.com/content/50/1/12</p><p>Acta Veterinaria Scandinavica 2008;50(1):12-12.</p><p>Published online 31 May 2008</p><p>PMCID:PMC2426689.</p><p></p

Design, synthesis, and pharmacological evaluation of 5-oxo-1,2,4-oxadiazole derivatives as AT₁ antagonists with antihypertension activities

<p>A series of new 5-oxo-1,2,4-oxadiazole derivatives with 1, 4-disubsituted or 1, 5-disubsituted indole group was designed, synthesized, and pharmacologically evaluated. These derivatives displayed high affinities to the AT₁ receptor at the same order of magnitude to losartan. The methyl ester with 1, 4-disubsituted indole group, 1 (5.01 ± 1.67 nM) showed high antihypertension activity on spontaneously hypertensive rats (SHRs). Its maximal response lowered 30 mmHg of mean blood pressure (MBP) at 10 mg/kg after oral administration, which was better than irbesartan, and the antihypertensive effect lasted beyond 24 h. These results made 1 deserve further investigation.</p