The Mediating Effect of Psychological Quality of Innovation and Entrepreneurship Education on Graduate Students' Innovation and Entrepreneurship Ability and Willingness

This work was supported by the Degree and Graduate Education Reform Key Projects of Guangdong Province, and the title is Exploration and Practice of Postgraduate Cultivation in Incorporating Innovation and Entrepreneurship Consciousness. Also, it was supported by the project of China Higher Education Association Thirteenth Five-Year Plan for Scientific Research in Higher Education (Grant number: 2018SYSZD08). Abstract Under the background of the innovation and entrepreneurship ability improvement plan proposed by the Ministry of education of China, the research on the subject of entrepreneurship and innovation is conducive to the continuous deepening of innovation and entrepreneurship education reform in Colleges and universities, and the continuous training and delivery of high-level talents for the construction of an innovative country. This paper explores the relationship among innovation and entrepreneurship ability, innovation and entrepreneurship education psychological quality and innovation and entrepreneurship willingness through a questionnaire survey of graduate students in Colleges and universities, analyzes the current situation, further confirms the hypothesis among the three, obtains positive results, and puts forward some countermeasures and suggestions for higher education. Keywords: Higher education, Graduate students, Willingness of innovation and entrepreneurship, Innovation and entrepreneurship ability, Psychological quality of innovation and entrepreneurship education DOI: 10.7176/JEP/11-19-06 Publication date:July 31st 202

Seismic control of a SDOF structure through electromagnetic resonant shunt tuned mass-damper-inerter and the exact H2 optimal solutions

This paper proposes a novel inerter-based component dynamic vibration absorber, namely, electromagnetic resonant shunt tuned mass-damper-inerter (ERS-TMDI). To analyze the performances of the ERS-TMDI, the combined ERS-TMDI and a single degree of freedom system are developed. The H2 norm performances of the ERS-TMDI, whose aim is to minimize the root mean square (RMS) value of structure damage under random ground acceleration excitation, are introduced in comparison with the energy-harvesting series electromagnetic tuned mass dampers (ERS-TMDs), tuned mass-damper-inerter (TMDI) and the classical tuned mass damper (TMD). The closed-form solutions, including the optimal mechanical tuning ratio, the optimal electrical damping ratio, the optimal electrical tuning ratio and the optimal electromagnetic mechanical coupling coefficient, are obtained. It is shown that the ERS-TMDI is superior to both the classical TMD and the ERS-TMD systems for protection from structure damage. Specifically, from the frequency-domain analyses, a case study is performed to illustrate the effectiveness, robustness of the ERS-TMDI and the sensitivity to the parameter changes. From the time-domain analyses, four types of earthquakes are studied to demonstrate the performances of vibration suppression

Frozen CLIP Model is An Efficient Point Cloud Backbone

The pretraining-finetuning paradigm has demonstrated great success in NLP and 2D image fields because of the high-quality representation ability and transferability of their pretrained models. However, pretraining such a strong model is difficult in the 3D point cloud field since the training data is limited and point cloud collection is expensive. This paper introduces Efficient Point Cloud Learning (EPCL), an effective and efficient point cloud learner for directly training high-quality point cloud models with a frozen CLIP model. Our EPCL connects the 2D and 3D modalities by semantically aligning the 2D features and point cloud features without paired 2D-3D data. Specifically, the input point cloud is divided into a sequence of tokens and directly fed into the frozen CLIP model to learn point cloud representation. Furthermore, we design a task token to narrow the gap between 2D images and 3D point clouds. Comprehensive experiments on 3D detection, semantic segmentation, classification and few-shot learning demonstrate that the 2D CLIP model can be an efficient point cloud backbone and our method achieves state-of-the-art accuracy on both real-world and synthetic downstream tasks. Code will be available.Comment: Technical repor

The Temporal and Spatial Evolution of Marathons in China from 2010 to 2018

The purpose of this study is to explore the spatial distribution pattern and influencing factors of the Chinese marathon. Geographic Information System (GIS) related spatial analysis tools were used to calculate the following: averaged nearest neighbor index, nuclear density analysis, and hot spot analysis amongst others. The spatial distribution evolution characteristics & influencing factors of 18 Chinese marathon events in year 2010, 129 in year 2015 and 342 in year 2018 were analyzed. The results show that: (a) In year 2010 Nearest neighbor ratio was 1.164714, Moran’s I was −0.010165 (type: Random), year 2015 was 0.502146, Moran’s I was 0.066267 (type: Clustered), and year 2018 was 0.531149, Moran’s I was 0.083485 (type: Clustered) ; (b) In year 2010 there was a 333.6 km search radius, The core circle of the Yangtze River Delta was adopted. In 2015 and 2018, the search radius of 556 km was adopted, which was respectively obtained from the core circle of the Yangtze River Delta, the core circle of Beijing-Tianjin-Hebei and the core circle of East China; (c) According to the Z value data, East China and North China in 2015 passed 95% of the confidence in 5 provinces and municipal hot spots, passed 90% of the confidence in 3 hot spots, and passed 95% of the confidence in Chongqing Cold Point. In 2018, East China, North China, Central Region and other eight provinces and cities hot spots passed 95% of the confidence, 4 hot spots passed 90% of the confidence, Tibet Autonomous Region cold spot passed 90% of the confidence. Conclusion: The overall distribution of marathon events is greater in the eastern region than the western region, greater in the southern region than the northern region, and greater in coastal regions than the inland regions; the nuclear density distribution has spread from the Yangtze River Delta mononuclear circle in 2010 to the core circle of the entire East China region. Moreover, it spread to North China, Central China, and South China; the distribution of hot spots spread from Shanghai, Jiangsu, and Zhejiang to the entire North China and East China regions. During the past 38 years of development of the Chinese marathon, it has been divided into three stages due to different political, economic and social environments

The natural environmental factors influencing the spatial distribution of marathon event: A case study from China

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Purpose: The purpose of this study was to investigate the influence of natural environmental factors on the spatial distribution of marathon events in China, and to identify the suitable natural environmental factors for the marathon events. Methods: Geographic information system (GIS) spatial analysis tools were used to perform coupling analysis, e.g. overlap, neighborhood, intersection and buffer for terrain, climate, air quality, mountains and water resources with 342 marathon events held in China in 2018. Results: The results indicate that the spatial distribution of marathon events in China is negatively correlated with the elevation of the terrain (plain \u3e hill \u3e plateau \u3e mountain \u3e basin); climate (subtropical monsoon climate \u3e temperate monsoon climate \u3e temperate continental climate \u3e tropical monsoon climate \u3e plateau alpine climate), air quality (level 3 \u3e level 2 \u3e level 4 \u3e level 1). Results indicate that buffer zones can protect water resources: there are 24 items in the buffer zone of river 0.5 km and lake 1 km, 131 items in the buffer zone of river 3 km and lake 5 km, 191 items in the buffer zone of river 5 km and lake 10 km, 298 items in the buffer zone of river 10 km and lake 20 km. Results indicate for mountain range buffer: 13 items in the 20 km buffer and 39 items in the 50 km buffer. Conclusions: Marathon events are more likely to be held on the third rung of China’s topography where a city has a typical landform (plains, basins, hills, or mountain) with good climate and air quality. Meanwhile a city with water and mountain resources for recreational events such as cross-country or obstacle course are essential. The contribution of this study is to systematically and intuitively reflect the influence of natural environment factors on the distribution of marathon events in China, and to provide evidence for the medium and long-term planning of marathon events in China, the selection of venues for different types of marathon events and how to attract participants

The Natural Environmental Factors Influencing the Spatial Distribution of Marathon Events：A Case Study from China

Purpose: The purpose of this study was to investigate the influence of natural environmental factors on the spatial distribution of marathon events in China, and to identify the suitable natural environmental factors for the marathon events. Methods: Geographic information system (GIS) spatial analysis tools were used to perform coupling analysis, e.g. overlap, neighborhood, intersection and buffer for terrain, climate, air quality, mountains and water resources with 342 marathon events held in China in 2018. Results: The results indicate that the spatial distribution of marathon events in China is negatively correlated with the elevation of the terrain (plain > hill > plateau > mountain > basin); climate (subtropical monsoon climate > temperate monsoon climate > temperate continental climate > tropical monsoon climate > plateau alpine climate), air quality (level 3 > level 2 > level 4 > level 1). Results indicate that buffer zones can protect water resources: there are 24 items in the buffer zone of river 0.5 km and lake 1 km, 131 items in the buffer zone of river 3 km and lake 5 km, 191 items in the buffer zone of river 5 km and lake 10 km, 298 items in the buffer zone of river 10 km and lake 20 km. Results indicate for mountain range buffer: 13 items in the 20 km buffer and 39 items in the 50 km buffer. Conclusions: Marathon events are more likely to be held on the third rung of China’s topography where a city has a typical landform (plains, basins, hills, or mountain) with good climate and air quality. Meanwhile a city with water and mountain resources for recreational events such as cross-country or obstacle course are essential. The contribution of this study is to systematically and intuitively reflect the influence of natural environment factors on the distribution of marathon events in China, and to provide evidence for the medium and long-term planning of marathon events in China, the selection of venues for different types of marathon events and how to attract participants

Neuroprotection Against MPP+-Induced Cytotoxicity Through the Activation of PI3-K/Akt/GSK3β/MEF2D Signaling Pathway by Rhynchophylline, the Major Tetracyclic Oxindole Alkaloid Isolated From Uncaria rhynchophylla

Rhynchophylline is a major tetracyclic oxindole alkaloid in Uncaria rhynchophylla, which has been extensively used as traditional herb medicine for the prevention of convulsions and hypertension. However, there is still little evidence about the neuroprotective effects of rhynchophylline for Parkinson’s disease (PD), a neurodegenerative condition currently without any effective cure. In this present study, the neuroprotective molecular mechanisms of rhynchophylline were investigated in a cellular model associated with PD. It is shown that rhynchophylline (10–50 μM) greatly prevented neurotoxicity caused by 1-methyl-4-phenylpyridinium ion (MPP+) in primary cerebellar granule neurons, as evidenced by the promotion of cell viability as well as the reversal of dysregulated protein expression of Bax/Bcl-2 ratio. Very encouragingly, we found that rhynchophylline markedly enhanced the activity of the transcription factor myocyte enhancer factor 2D (MEF2D) at both basal and pathological conditions using luciferase reporter gene assay, and reversed the inhibition of MEF2D caused by MPP+. Additionally, pharmacological inhibition of PI3-Kinase or short hairpin RNA-mediated gene down-regulation of MEF2D abrogated the protection provided by rhynchophylline. Furthermore, Western blot analysis revealed that rhynchophylline could potentiate PI3-K/Akt to attenuate GSK3β (the MEF2D inhibitor) in response to MPP+ insult. In conclusion, rhynchophylline inhibits MPP+-triggered neurotoxicity by stimulating MEF2D via activating PI3-K/Akt/GSK3β cascade. Rhynchophylline is served as a novel MEF2D enhancer and might be a potential candidate for further preclinical study in the prevention of PD

CTooth+: A Large-scale Dental Cone Beam Computed Tomography Dataset and Benchmark for Tooth Volume Segmentation

Accurate tooth volume segmentation is a prerequisite for computer-aided dental analysis. Deep learning-based tooth segmentation methods have achieved satisfying performances but require a large quantity of tooth data with ground truth. The dental data publicly available is limited meaning the existing methods can not be reproduced, evaluated and applied in clinical practice. In this paper, we establish a 3D dental CBCT dataset CTooth+, with 22 fully annotated volumes and 146 unlabeled volumes. We further evaluate several state-of-the-art tooth volume segmentation strategies based on fully-supervised learning, semi-supervised learning and active learning, and define the performance principles. This work provides a new benchmark for the tooth volume segmentation task, and the experiment can serve as the baseline for future AI-based dental imaging research and clinical application development

Improvement of Liquid Fructose-Induced Adipose Tissue Insulin Resistance by Ginger Treatment in Rats Is Associated with Suppression of Adipose Macrophage-Related Proinflammatory Cytokines

Adipose tissue insulin resistance (Adipo-IR) results in excessive release of free fatty acids from adipose tissue, which plays a key role in the development of “lipotoxicity.” Therefore, amelioration of Adipo-IR may benefit the treatment of other metabolic abnormalities. Here we found that treatment with the alcoholic extract of ginger (50 mg/kg/day, by oral gavage) for five weeks attenuated liquid fructose-induced hyperinsulinemia and an increase in the homeostasis model assessment of insulin resistance (HOMA-IR) index in rats. More importantly, ginger reversed the increases in the Adipo-IR index and plasma nonesterified fatty acid concentrations during the oral glucose tolerance test assessment. Adipose gene/protein expression profiles revealed that ginger treatment suppressed CD68 and F4/80, two important macrophage accumulation markers. Consistently, the macrophage-associated cytokines tissue necrosis factor alpha and interleukin-6 were also downregulated. In contrast, insulin receptor substrate (IRS)-1, but not IRS-2, was upregulated. Moreover, monocyte chemotactic protein (MCP)-1 and its receptor chemokine (C-C motif) receptor-2 were also suppressed. Thus these results suggest that amelioration of fructose-induced Adipo-IR by ginger treatment in rats is associated with suppression of adipose macrophage-related proinflammatory cytokines