Additional file 1: Figure S1. of Klotho ameliorates oxidized low density lipoprotein (ox-LDL)-induced oxidative stress via regulating LOX-1 and PI3K/Akt/eNOS pathways

50 µg/mL ox-LDL treatment induced decrease of cell viability in time dependent manner in HUVECs. Cells were treated with 50 µg/mL ox-LDL for indicated time. Cell viability were assayed by MTT assays. The results were presented as mean±SD from three independent experiments. ## p< 0.01. (JPG 8 kb

Graphene-Oxide-Directed Hydrothermal Synthesis of Ultralong M(VO₃)<i>_n</i> Composite Nanoribbons

New strategies for 1D materials fabrication are of fundamental importance in the advancement of science and technology. Instead of the small organic amine molecule- and the polymer-directed agent, here, we report a unified graphene-oxide-directed agent for the synthesis of a series of nanoribbons with different chemistries and with low dispersity, including V₂O₅, AgVO₃, and Sr­(VO₃)₂. This strategy is based on a general linear growth of vanadate and a splitting mechanism of graphene oxide during the synthesis. We believe our methodology provides a simple and convenient route to a variety of nanoribbon building blocks for assembling materials with novel structure and function in nanotechnology. More important is that graphene is in the middle of the composite structure; while supporting the main structure, it does not affect the mass transfer process. Compared to other composite structures based on graphene, such as graphene scroll and graphene sheet, graphene ribbon is more suitable for lithium-ion battery

Dependence of innate lymphoid cell 1 development on NKp46

<div><p>NKp46, a natural killer (NK) cell–activating receptor, is involved in NK cell cytotoxicity against virus-infected cells or tumor cells. However, the role of NKp46 in other NKp46⁺ non-NK innate lymphoid cell (ILC) populations has not yet been characterized. Here, an NKp46 deficiency model of natural cytotoxicity receptor 1 (<i>Ncr1</i>)^gfp/gfp and <i>Ncr1</i>^gfp/+ mice, i.e., homozygous and heterozygous knockout (KO), was used to explore the role of NKp46 in regulating the development of the NKp46⁺ ILCs. Surprisingly, our studies demonstrated that homozygous NKp46 deficiency resulted in a nearly complete depletion of the ILC1 subset (ILC1) of group 1 ILCs, and heterozygote KO decreased the number of cells in the ILC1 subset. Moreover, transplantation studies confirmed that ILC1 development depends on NKp46 and that the dependency is cell intrinsic. Interestingly, however, the cell depletion specifically occurred in the ILC1 subset but not in the other ILCs, including ILC2s, ILC3s, and NK cells. Thus, our studies reveal that NKp46 selectively participates in the regulation of ILC1 development.</p></div

Absence of TRAIL⁺ ILC1s in NKp46-deficient mice.

<p>(A) Percentages of TRAIL⁺ ILC1s were analyzed by flow cytometric analysis in the liver of <i>Ncr1</i>^gfp/gfp mice and their <i>Ncr1</i>^+/+ littermates. ILC1s were gated on Lin^─NK1.1⁺NKp46⁺(or GFP⁺ for <i>Ncr1</i>^gfp/gfp mice) TRAIL⁺CD49b^─ among lymphocytes. (B) Quantification of TRAIL⁺ ILC1s in the liver of <i>Ncr1</i>^gfp/gfp mice and their <i>Ncr1</i>^+/+ littermates for (A) (<i>n</i> = 5). (C) Quantification of TRAIL⁺ ILC1s in other organs (spleen, <i>n</i> = 5; BM, <i>n</i> = 5; SI, <i>n</i> = 4) of <i>Ncr1</i>^gfp/gfp mice and their <i>Ncr1</i>^+/+ littermates. **, <i>p</i> < 0.01; *, <i>p</i> < 0.05. The numerical data for panels B and C can be found in <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.2004867#pbio.2004867.s007" target="_blank">S1 Data</a>. Lin^─, CD3^─CD19^─; BM, bone marrow; GFP, green fluorescent protein; ILC1, innate lymphoid cell 1; <i>Ncr1</i>, natural cytotoxicity receptor 1; NK, natural killer; SI, small intestine; TRAIL, tumor necrosis factor–related apoptosis-inducing ligand.</p

High-Performance Flexible Single-Crystalline Silicon Nanomembrane Thin-Film Transistors with High‑<i>k</i> Nb₂O₅–Bi₂O₃–MgO Ceramics as Gate Dielectric on a Plastic Substrate

A novel method of fabricating flexible thin-film transistor based on single-crystalline Si nanomembrane (SiNM) with high-<i>k</i> Nb₂O₅–Bi₂O₃–MgO (BMN) ceramic gate dielectric on a plastic substrate is demonstrated in this paper. SiNMs are successfully transferred to a flexible polyethylene terephthalate substrate, which has been plated with indium-tin-oxide (ITO) conductive layer and high-<i>k</i> BMN ceramic gate dielectric layer by room-temperature magnetron sputtering. The BMN ceramic gate dielectric layer demonstrates as high as ∼109 dielectric constant, with only dozens of pA current leakage. The Si–BMN–ITO heterostructure has only ∼nA leakage current at the applied voltage of 3 V. The transistor is shown to work at a high current on/off ratio of above 10⁴, and the threshold voltage is ∼1.3 V, with over 200 cm²/(V s) effective channel electron mobility. Bending tests have been conducted and show that the flexible transistors have good tolerance on mechanical bending strains. These characteristics indicate that the flexible single-crystalline SiNM transistors with BMN ceramics as gate dielectric have great potential for applications in high-performance integrated flexible circuit

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Supplementary Materia

3396304.pdf

Supplementary materia