The accession of Cyprus to the EU: challenges and opportunities for the new European regional order

Der vorliegende Beitrag beleuchtet die Konsequenzen des EU-Beitritts Zyperns unter besonderer Berücksichtigung einer neuen europäischen Regionalordnung. Angesichts ihres hohen Bruttosozialproduktes scheint die Republik Zypern einer der besten Anwärter für die EU-Mitgliedschaft zu sein, und die zypriotischen Unterhändler versuchen, die Beitrittsverhandlungen mit Brüssel möglichst rasch voranzutreiben. Der andauernde Konflikt zwischen griechischen und türkischen Zyprioten wirft hinsichtlich des genauen Status Zyperns in der EU allerdings einige Fragen auf. Der Autor umreißt diese Probleme und entwirft ein wahrscheinliches Szenario für den Fall, dass das Beitrittsabkommen unterzeichnet wird. Da ein Beitritt Zyperns die europäische Ordnung beeinflussen würde, werden in diesem Beitrag sowohl die Implikationen für die Beziehungen zwischen der EU und der Türkei analysiert als auch die Auswirkungen auf die europäische Sicherheits- und Verteidigungspolitik. (ICD

Early loss of Crebbp confers malignant stem cell properties on lymphoid progenitors.

Loss-of-function mutations of cyclic-AMP response element binding protein, binding protein (CREBBP) are prevalent in lymphoid malignancies. However, the tumour suppressor functions of CREBBP remain unclear. We demonstrate that loss of Crebbp in murine haematopoietic stem and progenitor cells (HSPCs) leads to increased development of B-cell lymphomas. This is preceded by accumulation of hyperproliferative lymphoid progenitors with a defective DNA damage response (DDR) due to a failure to acetylate p53. We identify a premalignant lymphoma stem cell population with decreased H3K27ac, which undergoes transcriptional and genetic evolution due to the altered DDR, resulting in lymphomagenesis. Importantly, when Crebbp is lost later in lymphopoiesis, cellular abnormalities are lost and tumour generation is attenuated. We also document that CREBBP mutations may occur in HSPCs from patients with CREBBP-mutated lymphoma. These data suggest that earlier loss of Crebbp is advantageous for lymphoid transformation and inform the cellular origins and subsequent evolution of lymphoid malignancies

The Accession of Cyprus to the EU: Challenges and Opportunities for the New European Regional Order

With its GDP per capita being high enough and already approaching Western Europe on averages, the Republic of Cyprus appears to be one of the best candidates for European Union (EU) membership and its negotiators are making rapid progress in accession negotiations with Brussels. Yet, the continuing stand-off between the island's Greek- and Cypriot communities raises questions as to the exact status under which Cyprus will soon accede to the EU. The article addresses this problem and outlines what seems most likely to happen with the signing of the accession agreement. Given that the issue might crucially affect the way the European order of the near future will be shaped, the article also discusses the implications Cyprus' accession could possibly have on EU-Turkey relations and the European Security and Defence Policy (ESDP)

Predictors of embolism and death in left-sided infective endocarditis: the European Society of Cardiology EURObservational Research Programme European Infective Endocarditis registry

International audienceBackground and Aims Even though vegetation size in infective endocarditis (IE) has been associated with embolic events (EEs) and mortality risk, it is unclear whether vegetation size associated with these potential outcomes is different in left-sided IE (LSIE). This study aimed to seek assessing the vegetation cut-off size as predictor of EE or 30-day mortality for LSIE and to determine risk predictors of these outcomes. Methods The European Society of Cardiology EURObservational Research Programme European Infective Endocarditis is a prospective, multicentre registry including patients with definite or possible IE throughout 2016–18. Cox multivariable logistic regression analysis was performed to assess variables associated with EE or 30-day mortality. Results There were 2171 patients with LSIE (women 31.5%). Among these affected patients, 459 (21.1%) had a new EE or died in 30 days. The cut-off value of vegetation size for predicting EEs or 30-day mortality was >10 mm [hazard ratio (HR) 1.38, 95% confidence interval (CI) 1.13–1.69, P = .0015]. Other adjusted predictors of risk of EE or death were as follows: EE on admission (HR 1.89, 95% CI 1.54–2.33, P < .0001), history of heart failure (HR 1.53, 95% CI 1.21–1.93, P = .0004), creatinine >2 mg/dL (HR 1.59, 95% CI 1.25–2.03, P = .0002), Staphylococcus aureus (HR 1.36, 95% CI 1.08–1.70, P = .008), congestive heart failure (HR 1.40, 95% CI 1.12–1.75, P = .003), presence of haemorrhagic stroke (HR 4.57, 95% CI 3.08–6.79, P < .0001), alcohol abuse (HR 1.45, 95% CI 1.04–2.03, P = .03), presence of cardiogenic shock (HR 2.07, 95% CI 1.29–3.34, P = .003), and not performing left surgery (HR 1.30 95% CI 1.05–1.61, P = .016) (C-statistic = .68). Conclusions Prognosis after LSIE is determined by multiple factors, including vegetation size