Measuring the Determinants of Student Satisfaction in Practical Teacher Training Education Program in China

Despite extensive research on student satisfaction in HEIs, notable gaps exist in investigating the profound impact of practical teacher training in education programs, particularly in China. This study examines the relationships between student satisfaction and its predictors in practical teacher training among Chinese undergraduates. Results show that expectation, perceived administrative service quality, perceived teaching quality, and perceived value are significant predictors of student satisfaction. However, image and teacher-student interaction have no significant relationships with student satisfaction. The six constructs represent 49% of the variance in student satisfaction. These findings indicate the necessity for enhanced management of practical teacher training programs

Induction of the mesenchymal to epithelial transition by demethylation-activated microRNA-125b is involved in the anti-migration/invasion effects of arsenic trioxide on human chondrosarcoma

Background: In addition to treating acute promyelocytic leukemia, arsenic trioxide (ATO) suppresses other solid tumors, including chondrosarcoma. However, the effects of ATO on metastasis in chondrosarcoma cells, and the underlying molecular mechanisms remain unclear. Methods: The effects of ATO on the migratory and invasive capacities of chondrosarcoma cells were investigated by Wound healing, Transwell and EMT assays. The expression of miR-125b in human chondrosarcoma tissues and cell lines was detected by real-time PCR analysis. Bisulfite sequencing analysis (BSP) was used to detect the effects of ATO on the expression of miR-125b. The gain-of-function and loss-of-function experiments were performed on chondrosarcoma cell lines to investigate the effects of miR-125b on chondrosarcoma invasion, and to determine whether signal transducer and activator of transcription 3(Stat3) mediates these effects. Dual-luciferase reporter assay was used to identify whether Stat3 is a direct target of miR-125b. Results: MiR-125b was significantly downregulated in human metastatic chondrosarcoma tissues and cell lines but not in non-metastatic chondrosarcoma tissues. ATO up-regulates the expression of miR-125b by the demethylation of DNA. ATO induces MET and attenuates the invasive capacities of chondrosarcoma cells through miR-125b. Stat3 was verified as a direct target of miR-125b, which is involved in ATO regulating EMT-associated traits. Conclusions: These findings, for the first time, provides evidence that the miR-125b-mediated inhibition of Stat3 is involved in the ATO-induced attenuation of metastasis in chondrosarcoma cells.National Natural Science Foundation of China [81572633]; Research Fund for the Doctoral Program of Higher Education of China [20130001110076]SCI(E)[email protected]

Effects and Mechanisms of Transcutaneous Electroacupuncture on Chemotherapy-Induced Nausea and Vomiting

Nausea and vomiting are one of the major complications of chemotherapy for cancers. The aim of this study is to investigate the emetic effects and mechanisms involving serotonin and dopamine of needleless transcutaneous electroacupuncture (TEA) at Neiguan (PC6) and Jianshi (PC5) on chemotherapy-induced nausea and vomiting in patients with cancers. Seventy-two patients with chemotherapy were randomly divided into sham-TEA group (sham-TEA, n=34) and TEA group (n=38). TEA was performed at PC 6 and PC 5 (1 h, bid) in combination with granisetron. Sham-TEA was delivered at nonacupoints using the same parameters. We found the following. (1) In the acute phase, the conventional antiemetic therapy using Ondansetron effectively reduced nausea and vomiting; the addition of TEA did not show any additive effects. In the delayed phase, however, TEA significantly increased the rate of complete control (P<0.01) and reduced the nausea score (P<0.05), compared with sham-TEA. (2) TEA significantly reduced serum levels of 5-HT and dopamine in comparison with sham-TEA. Those results demonstrate that needleless transcutaneous electroacupuncture at PC6 using a watch-size digital stimulator improves emesis and reduces nausea in the delayed phase of chemotherapy in patients with cancers. This antiemetic effect is possibly mediated via mechanisms involving serotonin and dopamine

Numerical study on aerodynamic characteristics of high-speed trains with considering thermal-flow coupling effects

In order to conduct in-depth researches on rationality of air conditioning system equipment of a high-speed train as well as its pipeline system design, working conditions of the air conditioning system and distribution of aerodynamic characteristics including pressure, velocity and temperature in high speed trains should be computed carefully at the design stage. Therefore, the finite volume method was used to solve a governing equation of computational fluid dynamics. The aerodynamic characteristics of pipelines of the air conditioning system and the complete high speed train were computed, so the indoor distribution of wind velocity, temperature and gas concentration (carbon oxide, carbon dioxide, nitrogen and so forth) was obtained. The flow field index and the thermal comfort index were used to evaluate the indoor thermal comfort degree. In this way, whether rationality of the air conditioning system design and indoor aerodynamic characteristic could satisfy requirements for design specifications can be analyzed. Results show that: Under winter or summer working conditions, wind velocity was relatively high at the passageway door, where the maximum wind velocity was more than 1 m/s and would make passengers uncomfortable. Air flow velocity outside comfortable regions was more than 0.05 m/s, satisfying UIC553 standards. Velocity distribution was basically the same indoors, where wind velocity was large at positions perpendicular to the air supply hole, and the maximum wind velocity was more than 1 m/s, but wind velocity was uniform in the passenger region, which was basically lower than 0.2 m/s and satisfied UIC553 standards. In summer and winter working conditions, distribution of pressure, velocity and temperature was not uniform, where the maximum temperature gradient was near the air inlet in the compartment. Air components in the compartment satisfied requirements for comfort. The most uncomfortable regions in the compartment were concentrated at the passageway. Air supply holes distributed symmetrically on the train roof caused high air flow intensity, high wind velocity, low temperature and high humidity at the passageway in the compartment, so the thermal comfort was low, and it is feasible to adjust the layout of air supply holes appropriately

Cloning and Characterization of TpNRAMP3, a Metal Transporter From Polish Wheat (Triticum polonicum L.)

Essential transition metals and non-essential metals often co-exist in arable soils. In plants, some transition metal transporters, such as the natural resistance-associated macrophage proteins (NRAMPs), poorly selectively transport metals with similar chemical properties whether they are essential or non-essential. In this study, a member of the NRAMP transporter family, TpNRAMP3, was identified from dwarf Polish wheat (Triticum polonicum L.). TpNRAMP3 encodes a plasma membrane-localized protein and was highly expressed in leaf blades and roots at the jointing and booting stages, and in the first nodes at the grain filling stage. Expression of TpNRAMP3 increased sensitivity to Cd and Co, but not Zn, and increased the Cd and Co concentrations in yeast. TpNRAMP3 expression in Arabidopsis increased concentrations of Cd, Co, and Mn, but not Fe or Zn, in roots, shoots, and whole plant. However, TpNRAMP3 did not affect translocation of Cd, Co, or Mn from roots to shoots. These results suggest that TpNRAMP3 is a transporter for Cd, Co, and Mn accumulation, but not for Fe or Zn. However, Cd and Co are non-essential toxic metals; selective genetic manipulation of TpNRAMP3 will help breed low Cd- and Co-accumulating cultivars