Supersymmetric Spin Networks and Quantum Supergravity

We define supersymmetric spin networks, which provide a complete set of gauge invariant states for supergravity and supersymmetric gauge theories. The particular case of Osp(1/2) is studied in detail and applied to the non-perturbative quantization of supergravity. The supersymmetric extension of the area operator is defined and partly diagonalized. The spectrum is discrete as in quantum general relativity, and the two cases could be distinguished by measurements of quantum geometry.Comment: 21 pages, LaTex, 22 figures, typos corrected and references complete

Highly Sulfated Forms of Heparin Sulfate Are Involved in Japanese Encephalitis Virus Infection

AbstractJapanese encephalitis virus (JEV) infects a broad range of cell types in vitro, though little is known about the initial events of JEV infection. In the present study, we found that highly sulfated glycosaminoglycans (GAGs) are involved in infection of both neurovirulent (RP-9) and attenuated (RP-2ms) JEV strains. Competition experiments using highly sulfated GAGs, heparin and dextran sulfate, demonstrated an inhibition of JEV's attachment and subsequent infection of BHK-21 cells. Treatment of target cells by a potent sulfation inhibitor, sodium chlorate, greatly reduced viral binding ability as well as infection, suggesting a critical role of GAGs' sulfation status on the cellular surface in JEV infection. This phenomenon was confirmed by the manifestation of a distinct binding efficiency of JEV to the wild-type CHO cell line and its mutants with defects in GAG biosynthesis. We also demonstrated the binding of JEV particles and virus envelope glycoprotein to immobilized heparin beads. Furthermore, the addition of heparin suppressed the cytopathic effects induced by JEV infection in cultured cells. Our results establish that the highly sulfated form of GAGs on cell surfaces plays a determining role in the early stage of in vitro JEV infection

ANALYSIS OF TRUNK ROTATION PATTERNS WHEN SWINGING AT DIFFERENT SPEEDS: A PILOT STUDY

As the trunk plays a vital role during the golf full swing, it is important to understand how body movements affect the golf swing. The purpose of this study was to determine how golfers increase club head speed through trunk rotation. Trunk rotation patterns were captured by 3D motion capture system at 250 Hz. To investigate the effective factors of increasing club head speed, we compared two situations, swing at normal club head speed and at accelerated club head speed, via the trunk rotation angles at three dimensions through six temporary events. The results showed that subtle differences between normal club head speed and accelerated club head speed. To increase club head speed, golfers might optimize the separation between shoulder and pelvic in the early downswing

Effects of overexpression of IL-10, IL-12, TGF-β and IL-4 on allergen induced change in bronchial responsiveness

BACKGROUND: An increasing prevalence of allergic diseases, such as atopic dermatitis, allergic rhinitis and bronchial asthma, has been noted worldwide. Allergic asthma strongly correlates with airway inflammation caused by the unregulated production of cytokines secreted by allergen-specific type-2 T helper (Th2) cells. This study aims to explore the therapeutic effect of the airway gene transfer of IL-12, IL-10 and TGF-β on airway inflammation in a mouse model of allergic asthma. METHODS: BALB/c mice were sensitized to ovalbumin (OVA) by intraperitoneal injections with OVA and challenged by nebulized OVA. Different cytokine gene plasmids or non-coding vector plasmids were instilled daily into the trachea up to one day before the inhalatory OVA challenge phase. RESULTS: Intratracheal administration of IL-10, IL-12 or TGF-β can efficiently inhibit antigen-induced airway hyper-responsiveness and is able to largely significantly lower the number of eosinophils and neutrophils in bronchoalveolar lavage fluid of ovalbumin (OVA) sensitized and challenged mice during the effector phase. Furthermore, the effect of IL-10 plasmids is more remarkable than any other cytokine gene plasmid. On the other hand, local administration of IL-4 gene plasmids before antigen challenge can induce severe airway hyper-responsiveness (AHR) and airway eosinophilia. CONCLUSION: Our data demonstrated that anti- inflammatory cytokines, particularly IL-10, have the therapeutic potential for the alleviation of airway inflammation in murine model of asthma

Mechanical properties of La-based bulk amorphous alloy and composites

Influence of different microstructure of La-based fully amorphous samples and its composites on the impact fracture energy were investigated and discussed. Results showed improvement in fracture energy of glassy metals with the presence intermetallic phases, but deteriorated in the presence of dendrite phases and high volume % of crystalline phases.Singapore-MIT Alliance (SMA

Prediction Model of End Mill Cutting Edge Based on Material Properties and Cutting Conditions

In machining, the cutting performance of the tool depends on the tool material, tool structure, tool geometry, properties of workpiece materials, and cutting conditions. If the user chooses an inappropriate cutting tool for the machining of the workpiece material, this will cause energy loss and severe tool wear. This study aims to investigate the influence of mechanical properties of workpiece material and cutting conditions on the tool geometry and to establish a polynomial network for the prediction of a reasonable normal relief angle and a normal wedge angle based on experimental data. Experimental results indicate that the cutting of high hardness and high strength workpiece materials requires a larger normal wedge angle to increase the cutting edge strength. In addition, the design of the normal relief angle is related to Young\u27s modulus and the toughness of the workpiece material, mainly to avoid material elastic recovery during the cutting process. In terms of cutting parameters, as the radial depth of cut increases, the contact area between the tool and the chip increases, which causes the heat to concentrate at the tip of the tool; hence, it is necessary to increase the normal wedge angle. In addition, the feed per tooth had a negligible effect on the normal wedge angle. Finally, the prediction model was verified by five untested workpiece materials. The results of the cutting tests showed that the flatness of the cutting edge was less than 15 μm, which indicates that a normal cutting phenomenon occurred on the flank

Which Should Be Used First for ALK-Positive Non-Small-Cell Lung Cancer: Chemotherapy or Targeted Therapy? A Meta-Analysis of Five Randomized Trials

Background and objectives: Targeted therapy is widely used in the era of precision medicine. Whether the sequence in which targeted therapy and chemotherapy are performed matters, is however not known. We examined the impact of the sequential treatment of targeted therapy and chemotherapy among advanced anaplastic lymphoma kinase (ALK), non-small cell lung cancer (NSCLC) patients. Materials and Methods: Randomized controlled trials comparing the use of ALK inhibitors with chemotherapy were included in this meta-analysis. We estimated the hazard ratios (HRs) and 95% confidence intervals (CI), for progression-free survival (PFS) and overall survival (OS) from a random effects model. Two-sided statistical tests were used to determine the significance of these estimates. Results: In five eligible studies (1404 patients), ALK targeted therapy, in comparison with chemotherapy, had a significantly higher PFS (HR = 0.48; 95% CI, 0.42(-)0.55), but not significantly higher OS (HR = 0.88; 95% CI, 0.72(-)1.07). Crossover from chemotherapy to ALK inhibitors was allowed after progression in all trials. The sensitivity analysis of the use of ALK inhibitors as either the first- or second-line treatment, showed improvements in PFS but not in OS. Conclusions: Our results indicate that using targeted therapy first improved PFS, but that the sequence in which the treatments were performed did not cause a significant difference in overall survival

XRCC1, but not APE1 and hOGG1 gene polymorphisms is a risk factor for pterygium.

PurposeEpidemiological evidence suggests that UV irradiation plays an important role in pterygium pathogenesis. UV irradiation can produce a wide range of DNA damage. The base excision repair (BER) pathway is considered the most important pathway involved in the repair of radiation-induced DNA damage. Based on previous studies, single-nucleotide polymorphisms (SNPs) in 8-oxoguanine glycosylase-1 (OGG1), X-ray repair cross-complementing-1 (XRCC1), and AP-endonuclease-1 (APE1) genes in the BER pathway have been found to affect the individual sensitivity to radiation exposure and induction of DNA damage. Therefore, we hypothesize that the genetic polymorphisms of these repair genes increase the risk of pterygium.MethodsXRCC1, APE1, and hOGG1 polymorphisms were studied using fluorescence-labeled Taq Man probes on 83 pterygial specimens and 206 normal controls.ResultsThere was a significant difference between the case and control groups in the XRCC1 genotype (p=0.038) but not in hOGG1 (p=0.383) and APE1 (p=0.898). The odds ratio of the XRCC1 A/G polymorphism was 2.592 (95% CI=1.225-5.484, p=0.013) and the G/G polymorphism was 1.212 (95% CI=0.914-1.607), compared to the A/A wild-type genotype. Moreover, individuals who carried at least one C-allele (A/G and G/G) had a 1.710 fold increased risk of developing pterygium compared to those who carried the A/A wild type genotype (OR=1.710; 95% CI: 1.015-2.882, p=0.044). The hOGG1 and APE1 polymorphisms did not have an increased odds ratio compared with the wild type.ConclusionsXRCC1 (Arg399 Glu) is correlated with pterygium and might become a potential marker for the prediction of pterygium susceptibility