Searching strategy.

<p>Searching strategy.</p

The log₂ FC values of the three miRNAs in 19 cancer types.

<p>Fold change is the ratio of the median signals between cancer tissue and normal tissue. Abbreviations: FC, Fold change; PRAD, Prostate adenocarcinoma; BLCA, Bladder urothelial carcinoma; CHOL, Cholangiocarcinoma; COAD, Colon adenocarcinoma; ESCA, Esophageal carcinoma; HNSC, Head and neck squamous cell carcinoma; KICH, Kidney chromophobe; KIRC, Kidney renal clear cell carcinoma; KIRP, Kidney renal papillary cell carcinoma; LIHC, Liver hepatocellular carcinoma; LUAD, Lung adenocarcinoma; LUSC, Lung squamous cell carcinoma; PCPG, Pheochromocytoma and paraganglioma; READ, Rectal adenocarcinoma; STAD, Stomach adenocarcinoma; THCA, Thyroid carcinoma; THYM, Thymoma; PAAD, Pancreatic adenocarcinoma; and SKCM, Skin cutaneous melanoma. * The indicated miRNA expressed differentially in a cancer.</p

Correlations between the expressions of the three miRNAs and clinical features.

<p>Abbreviation: <i>r</i>_<i>s</i>, Spearman’s rank correlation coefficient</p><p>Correlations between the expressions of the three miRNAs and clinical features.</p

Candidate miRNAs for PCa biomarkers.

<p>Candidate miRNAs for PCa biomarkers.</p

Clusters of miRNA-target genes by their correlation coefficients.

<p>The heat map representation of the correlation patterns for the miRNA targets. The 267 differentially expressed target mRNAs, including 63 up-regulated targets and 204 down-regulated targets, were used to cluster the miRNAs. Rows of the heat map represent target mRNAs, and columns represent the miRNAs. Red squares indicate negative correlations, purple squares indicate positive correlations and white spots (colorless) indicate that there is no correlation.</p

Brief overview of the datasets.

<p>Abbreviations: TU, tumor sample; N, non-tumor sample; NA, not available; in the last column, the pairs, TU and N samples were from the same patient. TU(1): 72 tumor samples included 50 organ-confined PCa samples and 22 malignant trans-urethral resection of the PCa (TURP-PCa) samples. The numbers 5(2) indicate that the Gleason score was 5 for 2 PCa cases, the same as for the others.</p><p>Brief overview of the datasets.</p

Common target genes and biological pathways of the three miRNAs.

<p>The purple oval represents <i>RIMS3</i>; the three blue ovals represent the three miRNAs; black straight lines indicate the target effect of miRNAs on gene; dotted lines indicate the involvement of the miRNAs in PANTHER pathways, and their colors reflect the significances of -log₁₀ transformed <i>p</i> values for the pathways.</p

TCGA data for the three differentially expressed miRNAs in prostate primary solid tumor (n = 498) and normal solid tissue (n = 52).

<p>(A) The expression levels of miR-182 in prostate primary solid tumor and normal solid tissue. (B) The expression levels of miR-200c in prostate primary solid tumor and normal solid tissue. (C) The expression levels of miR-145 in prostate primary solid tumor and normal solid tissue. The expression level values were calculated using log_<b>2</b> transformed RPM values.</p