Propuesta de implementación de un sistema de gestión de seguridad y salud en el trabajo bajo la norma Ohsas 18001, para minimizar los factores de riesgo en la Institución Educativa Experimental Antonio Guillermo Urrelo

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Portable and Quantitative Detection of Protein Biomarkers and Small Molecular Toxins Using Antibodies and Ubiquitous Personal Glucose Meters

Developing portable and low-cost methods for quantitative detection of large protein biomarkers and small molecular toxins can play a significant role in controlling and preventing diseases or toxins outbreaks. Despite years of research, most current methods still require laboratory-based or customized devices that are not widely available to the general public for quantitative analysis. We have previously demonstrated the use of personal glucose meters (PGMs) and functional DNAs for the detection of many nonglucose targets. However, the range of targets detectable by functional DNAs is limited at the current stage. To expand the range of targets that can be detected by PGMs, we report here the use of antibodies in combination with sandwich and competitive assays for quantitative detection of protein biomarkers (PSA, with a detection limit of 0.4 ng/mL) and small molecular toxins (Ochratoxin A, with a detection limit of 6.8 ng/mL), respectively. In both assay methods, with invertase conjugates as the link, quantitative detection is achieved via the dependence between the concentrations of the targets in the sample and the glucose measured by PGMs. Given the wide availability of antibodies for numerous targets, the methods demonstrated here can expand the range of target detection by PGMs significantly

Additional file 1: of Metabolic characterization of human aqueous humor in the cataract progression after pars plana vitrectomy

Table S1. List of 263 detected metabolites with some important properties including CAS, KEGG and PubChem entry numbers. (XLS 58 kb

Regiospecific Hetero-Assembly of DNA-Functionalized Plasmonic Upconversion Superstructures

We report a novel strategy for regiospecific hetero-assembly of DNA-modified gold nanoparticles (DNA-AuNPs) onto upconversion nanoparticles (UCNPs) into hybrid lab-on-a-particle systems. The DNA-AuNPs have been assembled onto the hexagonal plate-like UCNPs with well-regulated stoichiometry and controlled organization onto the different facets of UCNP, forming various addressable superstructures. The fine-tuning of stoichiometry and organization is realized by biorecognition specificity of DNA toward specific crystal facets of UCNPs. Such a hetero-assembled DNA-AuNP/UCNP system maintains both plasmonic resonance of AuNPs and fluorescent properties of UCNPs, allowing targeted dual-modality imaging of cancer cells using an aptamer

Bayesian Registration of Functions With a Gaussian Process Prior

<p>We present a Bayesian framework for registration of real-valued functional data. At the core of our approach is a series of transformations of the data and functional parameters, developed under a differential geometric framework. We aim to avoid discretization of functional objects for as long as possible, thus minimizing the potential pitfalls associated with high-dimensional Bayesian inference. Approximate draws from the posterior distribution are obtained using a novel Markov chain Monte Carlo (MCMC) algorithm, which is well suited for estimation of functions. We illustrate our approach via pairwise and multiple functional data registration, using both simulated and real datasets. Supplementary material for this article is available online.</p

Table_1_Is hysterectomy associated with kidney cancer risk? A meta-analysis of cohort studies.docx

IntroductionEmerging evidence have suggested a potential relationship between hysterectomy and risk of kidney cancer with inconsistent results. We aimed to investigate the association of hysterectomy with kidney cancer risk based on a meta-analysis of all available cohort studies.MethodsA comprehensive literature search was performed in the PubMed and Embase database, covering all the papers published by September 2022. The pooled relative risks (RRs) and 95% confidence intervals (CIs) were estimated using a DerSimonian and Laird random effects model.ResultsOverall, our meta-analysis included 10 cohorts from 9 studies with approximately 240 million participants. The pooled RR with its 95% CI showed a significantly positive association between hysterectomy and risk of kidney cancer (RR 1.30, 95% CI 1.19-1.41). No obvious heterogeneity was observed across the studies (P = 0.206 for heterogeneity; I2 = 25.9%).ConclusionFindings from this meta-analysis of cohort studies indicated that hysterectomy was positively associated with subsequent kidney cancer risk. Further large prospective studies with long-term follow-up are warranted to verify these findings.</p

Conceptual Cross-Theoretical Assessment Model for Practitioners’ Compliance Behavior with Building Energy Codes

Conceptual Cross-Theoretical Assessment Model for Practitioners’ Compliance Behavior with Building Energy Code

Radiation-induced coronary artery disease during immune checkpoint inhibitor therapy: a case report

Supplementary material</p

Table_2_Is hysterectomy associated with kidney cancer risk? A meta-analysis of cohort studies.docx

IntroductionEmerging evidence have suggested a potential relationship between hysterectomy and risk of kidney cancer with inconsistent results. We aimed to investigate the association of hysterectomy with kidney cancer risk based on a meta-analysis of all available cohort studies.MethodsA comprehensive literature search was performed in the PubMed and Embase database, covering all the papers published by September 2022. The pooled relative risks (RRs) and 95% confidence intervals (CIs) were estimated using a DerSimonian and Laird random effects model.ResultsOverall, our meta-analysis included 10 cohorts from 9 studies with approximately 240 million participants. The pooled RR with its 95% CI showed a significantly positive association between hysterectomy and risk of kidney cancer (RR 1.30, 95% CI 1.19-1.41). No obvious heterogeneity was observed across the studies (P = 0.206 for heterogeneity; I2 = 25.9%).ConclusionFindings from this meta-analysis of cohort studies indicated that hysterectomy was positively associated with subsequent kidney cancer risk. Further large prospective studies with long-term follow-up are warranted to verify these findings.</p

Reductive Synthesis of Aminal Radicals for Carbon–Carbon Bond Formation

Aminal radicals were generated by reduction of the corresponding amidine or amidinium ion. The intermediate radicals participate in C–C bond-forming reactions to produce fully substituted aminal stereocenters. No toxic additives or reagents are required. More than 30 substrate combinations are reported, and chemical yields are as high as 99%