3,682 research outputs found
Computational intelligence approaches to robotics, automation, and control [Volume guest editors]
No abstract available
Variational Monte Carlo study of chiral spin liquid in the extended Heisenberg model on the Kagome lattice
We investigate the extended Heisenberg model on the Kagome lattice by using
Gutzwiller projected fermionic states and the variational Monte Carlo
technique. In particular, when both second- and third-neighbor super-exchanges
are considered, we find that a gapped spin liquid described by non-trivial
magnetic fluxes and long-range chiral-chiral correlations is energetically
favored compared to the gapless U(1) Dirac state. Furthermore, the topological
Chern number, obtained by integrating the Berry curvature, and the degeneracy
of the ground state, by constructing linearly independent states, lead us to
identify this flux state as the chiral spin liquid with fractionalized
Chern number.Comment: 9 pages, 7 figure
MiR-22 alleviates the proliferation and metastasis of melanoma by targeting FASN
Purpose: To determine the role of microRNA-22 (miR-22) in the development of malignant melanoma, and the underlying mechanism.
Methods: Potential miRNAs binding fatty acid synthase (FASN) were predicted by bioinformatics analysis, out of which miR-22 was selected. Their binding relationship was confirmed using dual-luciferase reporter assay. MicroRNA-22 and FASN levels in 40 clinical samples of melanoma were determined, and the correlation of the expression between miR-22 and FASN was assessed by Pearson correlation test. To uncover the role of miR-22 in regulating cell phenotypes of malignant melanoma, M21 and A375 cells were transfected with miRNA-NC, miR-22 mimics or miR-22 mimics + FASN-OE (FASN-over expression), respectively. Proliferative and metastatic abilities in each group were determined using cell counting kit-8 (CCK-8), 5-Ethynyl-2’- deoxyuridine (EdU) and Transwell assay, respectively.
Results: MiR-22 was the target gene binding the oncogene, FASN. Downregulated miR-22 and upregulated FASN were observed in melanoma tissues, showing a negative correlation between them. An overexpression of miR-22 significantly inhibited proliferative, migratory and invasive capacities in M21 and A375 cells (p < 0.05). Notably, overexpression of FASN abolished the inhibitory effects of miR-22 on proliferative and metastatic abilities in melanoma.
Conclusion: The level of expression of miR-22 in the malignant melanoma samples is low. Overexpression of miR-22 inhibits the proliferative and metastatic abilities of melanoma by targeting FASN and negatively regulating its level. Thus, miR-22 may be a promising therapeutic target of melanoma
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