Optimal Location of Sources in Transportation Networks

We consider the problem of optimizing the locations of source nodes in transportation networks. A reduction of the fraction of surplus nodes induces a glassy transition. In contrast to most constraint satisfaction problems involving discrete variables, our problem involves continuous variables which lead to cavity fields in the form of functions. The one-step replica symmetry breaking (1RSB) solution involves solving a stable distribution of functionals, which is in general infeasible. In this paper, we obtain small closed sets of functional cavity fields and demonstrate how functional recursions are converted to simple recursions of probabilities, which make the 1RSB solution feasible. The physical results in the replica symmetric (RS) and the 1RSB frameworks are thus derived and the stability of the RS and 1RSB solutions are examined.Comment: 38 pages, 18 figure

Anxiety and depression with neurogenesis defects in exchange protein directly activated by cAMP 2-deficient mice are ameliorated by a selective serotonin reuptake inhibitor, Prozac

Intracellular cAMP and serotonin are important modulators of anxiety and depression. Fluoxetine, a selective serotonin reuptake inhibitor (SSRI) also known as Prozac, is widely used against depression, potentially by activating cAMP response element-binding protein (CREB) and increasing brain-derived neurotrophic factor (BDNF) through protein kinase A (PKA). However, the role of Epac1 and Epac2 (Rap guanine nucleotide exchange factors, RAPGEF3 and RAPGEF4, respectively) as potential downstream targets of SSRI/cAMP in mood regulations is not yet clear. Here, we investigated the phenotypes of Epac1 (Epac1− / −) or Epac2 (Epac2− / −) knockout mice by comparing them with their wild-type counterparts. Surprisingly, Epac2− / − mice exhibited a wide range of mood disorders, including anxiety and depression with learning and memory deficits in contextual and cued fear-conditioning tests without affecting Epac1 expression or PKA activity. Interestingly, rs17746510, one of the three single-nucleotide polymorphisms (SNPs) in RAPGEF4 associated with cognitive decline in Chinese Alzheimer’s disease (AD) patients, was significantly correlated with apathy and mood disturbance, whereas no significant association was observed between RAPGEF3 SNPs and the risk of AD or neuropsychiatric inventory scores. To further determine the detailed role of Epac2 in SSRI/serotonin/cAMP-involved mood disorders, we treated Epac2− / − mice with a SSRI, Prozac. The alteration in open field behavior and impaired hippocampal cell proliferation in Epac2− / − mice were alleviated by Prozac. Taken together, Epac2 gene polymorphism is a putative risk factor for mood disorders in AD patients in part by affecting the hippocampal neurogenesis.published_or_final_versio

Observing two dark accelerators around the Galactic Centre with Fermi Large Area Telescope

We report the results from a detailed $\gamma-$ray investigation in the field of two "dark accelerators", HESS J1745-303 and HESS J1741-302, with $6.9$ years of data obtained by the Fermi Large Area Telescope. For HESS J1745-303, we found that its MeV-GeV emission is mainly originated from the "Region A" of the TeV feature. Its $\gamma-$ray spectrum can be modeled with a single power-law with a photon index of $\Gamma\sim2.5$ from few hundreds MeV to TeV. Moreover, an elongated feature, which extends from "Region A" toward northwest for $\sim1.3^{\circ}$, is discovered for the first time. The orientation of this feature is similar to that of a large scale atomic/molecular gas distribution. For HESS J1741-302, our analysis does not yield any MeV-GeV counterpart for this unidentified TeV source. On the other hand, we have detected a new point source, Fermi J1740.1-3013, serendipitously. Its spectrum is apparently curved which resembles that of a $\gamma-$ray pulsar. This makes it possibly associated with PSR B1737-20 or PSR J1739-3023.Comment: 11 pages, 7 figures, 2 tables, accepted for publication in MNRA

Enhancing Transport Efficiency by Hybrid Routing Strategy

Traffic is essential for many dynamic processes on real networks, such as internet and urban traffic systems. The transport efficiency of the traffic system can be improved by taking full advantage of the resources in the system. In this paper, we propose a dual-strategy routing model for network traffic system, to realize the plenary utility of the whole network. The packets are delivered according to different "efficient routing strategies" [Yan, et al, Phys. Rev. E 73, 046108 (2006)]. We introduce the accumulate rate of packets, {\eta} to measure the performance of traffic system in the congested phase, and propose the so-called equivalent generation rate of packet to analyze the jamming processes. From analytical and numerical results, we find that, for suitable selection of strategies, the dual- strategy system performs better than the single-strategy system in a broad region of strategy mixing ratio. The analytical solution to the jamming processes is verified by estimating the number of jammed nodes, which coincides well with the result from simulation.Comment: 6 pages, 3 figure

Types of Control in Acupuncture Clinical Trials Might Affect the Conclusion of the Trials: A Review of Acupuncture on Pain Management

published_or_final_versio

Phase Separation Kinetics in a Model with Order-Parameter Dependent Mobility

We present extensive results from 2-dimensional simulations of phase separation kinetics in a model with order-parameter dependent mobility. We find that the time-dependent structure factor exhibits dynamical scaling and the scaling function is numerically indistinguishable from that for the Cahn-Hilliard (CH) equation, even in the limit where surface diffusion is the mechanism for domain growth. This supports the view that the scaling form of the structure factor is "universal" and leads us to question the conventional wisdom that an accurate representation of the scaled structure factor for the CH equation can only be obtained from a theory which correctly models bulk diffusion.Comment: To appear in PRE, figures available on reques

China and the crisis : global power, domestic caution and local initiative

Even though the global crisis had a quick and dramatic impact on Chinese exports, the Chinese government responded with a range of policy responses that have helped maintain high rates of growth. This success has helped propel China to the centre of global politics, accelerating what many perceive to be a power shift from the West to China. But these gains were achieved by reversing policy in previous years designed to make a fundamental shift in China‟s mode of development, and have highlighted the problems associated with making such a transition. At the moment that many are looking at the Chinese "model" as a potential alternative to the Washington Consensus, one of the consequences of the crisis is to further question the long term efficacy of this "model" in China itself

Networking - A Statistical Physics Perspective

Efficient networking has a substantial economic and societal impact in a broad range of areas including transportation systems, wired and wireless communications and a range of Internet applications. As transportation and communication networks become increasingly more complex, the ever increasing demand for congestion control, higher traffic capacity, quality of service, robustness and reduced energy consumption require new tools and methods to meet these conflicting requirements. The new methodology should serve for gaining better understanding of the properties of networking systems at the macroscopic level, as well as for the development of new principled optimization and management algorithms at the microscopic level. Methods of statistical physics seem best placed to provide new approaches as they have been developed specifically to deal with non-linear large scale systems. This paper aims at presenting an overview of tools and methods that have been developed within the statistical physics community and that can be readily applied to address the emerging problems in networking. These include diffusion processes, methods from disordered systems and polymer physics, probabilistic inference, which have direct relevance to network routing, file and frequency distribution, the exploration of network structures and vulnerability, and various other practical networking applications.Comment: (Review article) 71 pages, 14 figure

Evolution of speckle during spinodal decomposition

Time-dependent properties of the speckled intensity patterns created by scattering coherent radiation from materials undergoing spinodal decomposition are investigated by numerical integration of the Cahn-Hilliard-Cook equation. For binary systems which obey a local conservation law, the characteristic domain size is known to grow in time $\tau$ as $R = [B \tau]^n$ with n=1/3, where B is a constant. The intensities of individual speckles are found to be nonstationary, persistent time series. The two-time intensity covariance at wave vector ${\bf k}$ can be collapsed onto a scaling function $Cov(\delta t,\bar{t})$, where $\delta t = k^{1/n} B |\tau_2-\tau_1|$ and $\bar{t} = k^{1/n} B (\tau_1+\tau_2)/2$. Both analytically and numerically, the covariance is found to depend on $\delta t$ only through $\delta t/\bar{t}$ in the small-$\bar{t}$ limit and $\delta t/\bar{t} ^{1-n}$ in the large-$\bar{t}$ limit, consistent with a simple theory of moving interfaces that applies to any universality class described by a scalar order parameter. The speckle-intensity covariance is numerically demonstrated to be equal to the square of the two-time structure factor of the scattering material, for which an analytic scaling function is obtained for large $\bar{t}.$ In addition, the two-time, two-point order-parameter correlation function is found to scale as $C(r/(B^n\sqrt{\tau_1^{2n}+\tau_2^{2n}}),\tau_1/\tau_2)$, even for quite large distances $r$. The asymptotic power-law exponent for the autocorrelation function is found to be $\lambda \approx 4.47$, violating an upper bound conjectured by Fisher and Huse.Comment: RevTex: 11 pages + 12 figures, submitted to PR

Density mismatch in thin diblock copolymer films

Thin films of diblock copolymer subject to gravitational field are simulated by means of a cell dynamical system model. The difference in density of the two sides of the molecule and the presence of the field causes the formation of lamellar patterns with orientation parallel to the confining walls even when they are neutral. The concentration profile of those films is analyzed in the weak segregation regime and a functional form for the profile is proposed.Comment: 9 pages and 8 figures. Needs EPSF macros. Submitted to PR