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    KOREA: KLUCZ DALEKIEGO WSCHODU (1905) I POGLฤ„DY WACลAWA SIEROSZEWSKIEGO NA TEMAT KOREI

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    The aim of this paper is to review Wacล‚aw C. Sieroszewskiโ€™s (1858-1945) view of Korea. He, well-known Polish writer, traveled to Korea, i. e., Daehan Empire (ๅคง้Ÿ“ๅธๅœ‹), in fall of 1903, and published Korea: Klucz Dalekiego Wschodu (1905). Considering that most of travelogues of Korea were written by American, British, French, and German, so-called โ€œWestern powers,โ€ KKDW was a pretty valuable book.The author believes that Western view of Korea was notably changed around the late eighteenth century. In the seventeenth and eighteenth centuries, Europeans did not ignore or belittle Korea and Korean. They regarded Korea as a rich and well-systemized country, and Korean as an intelligent nation, although they had very little knowledge of Korea. On the other hand, generally speaking, they degraded Korea and Korean in the nineteenth and early twentieth centuries, and Sieroszewski was one of them. Poland was one of the weakest countries in Europe, but his view was not different from that of American, British, French, and German authors.Sieroszewski was favorably impressed by Japan before he came to Korea in October, 1903, and, as a result, he constantly compared Korea and Japan. He even wrote that Japan was better than Europe in some ways. He truly believed that Japan was the only country to carry out a desirable reform for Korea. Meanwhile, he never approved the Russiaโ€™s imperialist ambition for Korea. He considered Japan as an agent of the West. In conclusion, his idea of Korea and the East was quite similar to that of other contemporary Western travelers.๋ณธ ๋…ผ๋ฌธ์€ ํด๋ž€๋“œ ์ž‘๊ฐ€ ๋ฐ”์ธ ์™€ํ”„ ์‰๋กœ์…ฐํ”„์Šคํ‚ค (Wacล‚aw C. Sieroszewski, 1858~1945)์˜ ์ €์„œ ใ€Ž๊ทน๋™์˜ ์—ด์‡  ํ•œ๊ตญ (Korea : Klucz Dalekiego Wschodu)ใ€(1905)์— ๋‚˜ํƒ€๋‚œ ํ•œ๊ตญ ์ธ์‹์„ ๊ฒ€ํ† ํ•˜๋ ค๋Š” ๋ชฉ์ ์—์„œ ์ง‘ํ•„๋˜์—ˆ๋‹ค. ใ€Ž๊ทน๋™์˜ ์—ด์‡  ํ•œ๊ตญใ€์€ 19์„ธ๊ธฐ ๋ง๊ณผ 20์„ธ๊ธฐ ์ดˆ์— ์–‘์‚ฐ๋œ ์„œ์–‘์ธ๋“ค์˜ ํ•œ๊ตญ๊ฒฌ๋ฌธ๋ก ์ค‘ ๊ฑฐ์˜ ์œ ์ผํ•˜๊ฒŒ ํด๋ž€๋“œ์ธ์ด ์ž‘์„ฑํ•œ ์ฑ…์œผ๋กœ, ๋Œ€๋‹ค์ˆ˜์˜ ํ•œ๊ตญ ๊ด€๊ณ„ ๋ฌธํ—Œ์ด ๋ฏธ๊ตญ, ์˜๊ตญ, ํ”„๋ž‘์Šค, ๋…์ผ ๋“ฑ ์†Œ์œ„ ์„œ์–‘ ์—ด๊ฐ• ์—ฌํ–‰์ž๋“ค์˜ ๊ฒƒ์ž„์„ ๊ณ ๋ คํ•  ๋•Œ ์ƒ๋‹นํžˆ ํฌ์†Œ์„ฑ ๋†’์€ ์ž๋ฃŒ๋ผ๊ณ  ํ‰๊ฐ€ํ•  ์ˆ˜ ์žˆ๋‹ค. ์„œ์–‘์ธ๋“ค์ด ํ•œ๊ตญ์„ ๋ฐ”๋ผ๋ณด๋Š” ๋ฐฉ์‹์€ 18์„ธ๊ธฐ ํ›„๋ฐ˜์— ์‹œ์ž‘๋œ ์„œ๊ตฌ ์„ธ๊ณ„์˜ ๋ณ€ํ™”์™€ ํ•จ๊ป˜ ๋‹ฌ๋ผ์กŒ๋‹ค. ๊ฐ€๋ น 17~18์„ธ๊ธฐ์˜ ์œ ๋Ÿฝ์ธ๋“ค์€ ํ•œ๊ตญ์— ๊ด€ํ•œ ์ง€์‹์ด ๊ทนํžˆ ๋นˆ์•ฝํ•˜์˜€์œผ๋‚˜, ํ•œ๊ตญ์„ ์„ฃ๋ถˆ๋ฆฌ ๋ฌด์‹œํ•˜๊ฑฐ๋‚˜ ๊ฒฝ๋ฉธํ•˜์ง€๋Š” ์•Š์•˜๋˜ ๊ฒƒ ๊ฐ™๋‹ค. ๊ทธ ์ด์œ ๋Š” ๋‹น์‹œ ์„ธ๊ณ„ ์งˆ์„œ์—์„œ ์•„์‹œ์•„๊ฐ€ ์ฐจ์ง€ํ•˜๊ณ  ์žˆ์—ˆ๋˜ ์šฐ์›”ํ•œ ์ง€์œ„ ๋•Œ๋ฌธ์ด๋ผ๊ณ  ์ƒ๊ฐ๋œ๋‹ค. ๊ทธ๋“ค์€ ์„œ๊ตฌ ๋ฌธ๋ช…๋ณด๋‹ค ์ค‘๊ตญ ๋ฌธ๋ช…์„ ๋†’์ด ํ‰๊ฐ€ํ•˜์˜€๊ณ , ๊ฒฝ์ œ์ ์œผ๋กœ๋„ ์•„์‹œ์•„์— ์˜์กดํ•˜๊ณ  ์žˆ์—ˆ๋˜ ๊ฒƒ์ด๋‹ค. ๋ฐ˜๋ฉด 19์„ธ๊ธฐ ์ดํ›„ โ€˜์„œ๊ตฌ์˜ ์‹œ๋Œ€โ€™ ์— ์ถœ๊ฐ„๋œ ํ•œ๊ตญ ๊ด€๊ณ„ ๋ฌธํ—Œ๋“ค์€ ํ•œ๊ตญ์— ๋Œ€ํ•œ ๋น„ํ•˜๋ฅผ ๊ธฐ๋ณธ ์ž์„ธ๋กœ ์‚ผ์•˜๋˜ ๋“ฏํ•˜๋‹ค. ใ€Ž๊ทน๋™์˜ ์—ด์‡  ํ•œ๊ตญใ€๋„ ๋งˆ์ฐฌ๊ฐ€์ง€์ด๋‹ค. ์ €์ž ์‰๋กœ์…ฐํ”„์Šคํ‚ค์˜ ๋ชจ๊ตญ ํด๋ž€๋“œ๋Š” ๋‹น์‹œ ์œ ๋Ÿฝ์—์„œ ๊ฐ€์žฅ ํ—ˆ์•ฝํ•œ ๋‚˜๋ผ ์ค‘ ํ•˜๋‚˜์˜€์œผ๋‚˜, ๊ทธ๊ฐ€ ํ•œ๊ตญ์„ ๋ณด๋˜ ๋ˆˆ์€ ์„œ์–‘ ๊ฐ•๋Œ€๊ตญ ์ถœ์‹  ์‚ฌ๋žŒ๋“ค์˜ ๊ทธ๊ฒƒ๊ณผ ๋ณ„๋‹ค๋ฅธ ์ฐจ์ด๊ฐ€ ์—†์—ˆ๋˜ ๊ฒƒ์œผ๋กœ ํŒ๋‹จ๋œ๋‹ค. ์‰๋กœ์…ฐํ”„์Šคํ‚ค๋Š” ๋Š์ž„์—†์ด ํ•œ๊ตญ๊ณผ ์ผ๋ณธ์„ ๋Œ€๋น„์‹œ์ผฐ๋‹ค. 1903๋…„ 10์›” ํ•œ๊ตญ์— ์˜ค๊ธฐ ์ „ ์ผ๋ณธ์— ์ฒด๋ฅ˜ํ•˜๋ฉด์„œ ๋Œ€๋‹จํžˆ ๊ธ์ •์ ์ธ ์ธ์ƒ์„ ๋ฐ›์•˜๊ธฐ ๋•Œ๋ฌธ์ด๋‹ค. ๊ทธ๋Š” ์–ด๋–ค ์ ์—์„œ๋Š” ์ผ๋ณธ์ด ์œ ๋Ÿฝ๋ณด๋‹ค ๋‚ซ๋‹ค๊ณ  ํ•  ๋งŒํผ ์ผ๋ณธ์— ๋งค๋ฃŒ๋˜์—ˆ๋‹ค. ๊ทธ๋ฆฌํ•˜์—ฌ ์˜ค์ง ์ผ๋ณธ๋งŒ์ด ํ•œ๊ตญ์„ ์œ„ํ•˜์—ฌ ๋ฐ”๋žŒ์งํ•œ ๊ฐœํ˜์„ ์‹œํ–‰ํ•  ๊ฒƒ์ด๋ผ๊ณ  ํ™•์‹ ํ•œ ๋ฐ˜๋ฉด, ๊ฐ™์€ ์œ ๋Ÿฝ ๊ตญ๊ฐ€์ธ ๋Ÿฌ์‹œ์•„์˜ ์ง€๋ฐฐ์š•์— ๊ด€ํ•ด์„œ๋Š” (ํด๋ž€๋“œ๊ฐ€ ๋Ÿฌ์‹œ์•„์˜ ์ง€๋ฐฐ๋ฅผ ๋ฐ›๊ณ  ์žˆ์—ˆ๋˜ ๊ฒƒ๋„ ์ด์œ ๊ฐ€ ๋˜๊ฒ ์ง€๋งŒ) ์กฐ๊ธˆ๋„ ํ˜ธ์‘ํ•˜์ง€ ์•Š์•˜๋‹ค. ์ฆ‰, ๊ทธ๋Š” ์ผ๋ณธ์„ ๋™์•„์‹œ์•„์—์„œ ์„œ์–‘์˜ ๋Œ€์ฒด์ž๋กœ ๊ฐ„์ฃผํ•œ ๊ฒƒ์ธ๋ฐ, ์ด ๋˜ํ•œ ๋ฏธ๊ตญ, ์˜๊ตญ, ํ”„๋ž‘์Šค, ๋…์ผ ๋“ฑ์ง€์—์„œ ํ•œ๊ตญ์„ ๋ณด๋Ÿฌ ์™”๋˜ ์ด๋“ค์˜ ์ž…์žฅ๊ณผ ํก์‚ฌํ•œ ๊ฒƒ์œผ๋กœ ํ•ด์„๋œ๋‹ค.Celem pracy jest dokonanie przeglฤ…du poglฤ…dรณw na temat Korei Wacล‚awa C. Sieroszewskiego (1858-1945). Ten znany polski pisarz wyjechaล‚ do Korei to jest tak zwanego imperium Daehan (ๅคง ้Ÿ“ๅธๅœ‹) jesieniฤ… 1903 r. Nastฤ™pnie opublikowaล‚ ksiฤ…ลผkฤ™ o Korei: Klucz Dalekiego Wschodu (1905) (KDW). Biorฤ…c pod uwagฤ™, ลผe wiฤ™kszoล›ฤ‡ dziennikรณw zย podrรณลผy do Korei zostaล‚a napisana przez amerykaล„skich, brytyjskich, francuskich i niemieckich pisarzy z tak zwanych โ€žmocarstw zachodnichโ€, KDW stanowi cenne ลบrรณdล‚o informacji

    Remission of lymphoblastic leukaemia in an intravascular fluidic environment by pliable drug carrier with a sliding target ligand

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    A polyrotaxane-based nanoconstruct with pliable structure carrying a chemotherapeutic drug was developed for targeting circulating lymphoblastic leukaemia cells in a fluidic environment of blood vessels in vivo. By introducing lymphoblast targeting aptamer DNA through cyclodextrin, threaded in poly(ethylene glycol) as polyrotaxane, target aptamer slides along the long polymeric chain and actively search for target ligand, leading to active targeting in dynamic fluidic system which is enhanced by up to 6-fold compared with that of control carriers with non-sliding targeting ligands. Moreover, the drug carrier was made stimuli-responsive by employing i-motif DNA to selective releases of its payload at intracellular acidic condition. These combined features resulted in the effective remission of lymphoblastic leukaemia both in vitro and in dynamic blood vessels in vivo.1142Ysciescopu

    anti-9,10-Di(1-naphthยญyl)anthracene pyridine disolvate

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    In the title compound, C34H22ยท2C5H5N, there is a crystallographic inversion center in the middle of the anthracene ring system. The dihedral angle between the mean planes of the anthracene and naphthalene ring systems is 83.96โ€…(4)ยฐ. The crystal structure is stabilized by weak interยญmolecular Cโ€”Hโ‹ฏN and Cโ€”Hโ‹ฏฯ€ interยญactions

    Self-assembled nanocomplex between polymerized phenylboronic acid and doxorubicin for efficient tumor-targeted chemotherapy

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    Since the discovery that nano-scaled particulates can easily be incorporated into tumors via the enhanced permeability and retention (EPR) effect, such nanostructures have been exploited as therapeutic small molecule delivery systems. However, the convoluted synthetic process of conventional nanostructures has impeded their feasibility and reproducibility in clinical applications. Herein, we report an easily prepared formulation of self-assembled nanostructures for systemic delivery of the anti-cancer drug doxorubicin (DOX). Phenylboronic acid (PBA) was grafted onto the polymeric backbone of poly(maleic anhydride). pPBA-DOX nanocomplexes were prepared by simple mixing, on the basis of the strong interaction between the 1,3-diol of DOX and the PBA moiety on pPBA. Three nanocomplexes (1, 2, 4) were designed on the basis of [PBA]:[DOX] molar ratios of 1: 1, 2: 1, and 4: 1, respectively, to investigate the function of the residual PBA moiety as a targeting ligand. An acid-labile drug release profile was observed, owing to the intrinsic properties of the phenylboronic ester. Moreover, the tumor-targeting ability of the nanocomplexes was demonstrated, both in vitro by confocal microscopy and in vivo by fluorescence imaging, to be driven by an inherent property of the residual PBA. Ligand competition assays with free PBA pre-treatment demonstrated the targeting effect of the residual PBA from the nanocomplexes 2 and 4. Finally, the nanocomplexes 2 and 4, compared with the free DOX, exhibited significantly greater anti-cancer effects in vitro and even in vivo. Our pPBA-DOX nanocomplex enables a new paradigm for self-assembled nanostructures with potential biomedical applications.115Ysciescopu

    Hennekam Syndrome: A Case Report

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    Hennekam syndrome is a rare autosomal recessive disorder resulting from malformation of the lymphatic system. The characteristic signs of Hennekam syndrome are lymphangiectasia, lymph edema, facial anomalies, and mental retardation. This is a case in which a patient presented with left-arm lymphedema, facial-feature anomalies, and multiple organ lymphangiectasia consistent with symptoms of Hennekam syndrome. There is no curative therapy at this time, but rehabilitative treatments including complete decongestive therapy for edema control appeared to be beneficial

    Tissue expression and antibacterial activity of host defense peptides in chicken

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    This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.Abstract Background Host defence peptides are a diverse group of small, cationic peptides and are important elements of the first line of defense against pathogens in animals. Expression and functional analysis of host defense peptides has been evaluated in chicken but there are no direct, comprehensive comparisons with all gene family and individual genes. Results We examined the expression patterns of all known cathelicidins, ฮฒ-defensins and NK-lysin in multiple selected tissues from chickens. CATH1 through 3 were predominantly expressed in the bone marrow, whereas CATHB1 was predominant in bursa of Fabricius. The tissue specific pattern of ฮฒ-defensins generally fell into two groups. ฮฒ-defensin1-7 expression was predominantly in bone marrow, whereas ฮฒ-defensin8-10 and ฮฒ-defensin13 were highly expressed in liver. NK-lysin expression was highest in spleen. We synthesized peptide products of these gene families and analysed their antibacterial efficacy. Most of the host defense peptides showed antibacterial activity against E.coli with dose-dependent efficacy. ฮฒ-defensin4 and CATH3 displayed the strongest antibacterial activity among all tested chicken HDPs. Microscopic analyses revealed the killing of bacterium by disrupting membranes with peptide treatment. Conclusions These results demonstrate dose-dependent antimicrobial effects of chicken HDPs mediated by membrane damage and demonstrate the differential tissue expression pattern of bioactive HDPs in chicken and the relative antimicrobial potency of the peptides they encode

    Refractory Hypertension and Isosexual Pseudoprecocious Puberty Associated with Renin-Secreting Ovarian Steroid Cell Tumor in a Girl

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    Steroid cell tumor, not otherwise specified (NOS), are rare ovarian tumor, in addition, it is more rare in children. The majority of these tumors produce several steroid hormones, particularly testosterone. Estrogen also secreted by steroid cell tumor, NOS, but it is uncommon. Furthermore, hypertension is an infrequent sign in steroid cell tumor, NOS. An 8.5-yr-old girl with hypertension and frequent vaginal spotting visited at our clinic. On laboratory evaluation, secondary hypertension due to an elevated plasma renin level and isosexual pseudoprecocious puberty was diagnosed. Right solid ovarian mass was detected in radiologic tests. She underwent a right ooporectomy and it revealed renin and progesterone receptor positive steroid cell tumor, NOS. After operation, her blood pressure returned to normal level and vaginal bleeding disappeared. Even though this case is very rare, when hypertension coincides with virilization or feminization, a renin-secreting ovarian steroid cell tumor, NOS, should be considered
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