8,005 research outputs found
No evidence of a significant role for CTLA-4 in multiple sclerosis
Variation in the cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) gene plays a significant role in determining susceptibility to autoimmune thyroid disease and type 1 diabetes. Its role in multiple sclerosis is more controversial. In order to explore this logical candidate more thoroughly, we genotyped 771 multiple sclerosis trio families from the United Kingdom for the 3? untranslated region variable number tandem repeat, the CT60 single nucleotide polymorphism (SNP) and five haplotype-tagging SNPs. No individual marker or common haplotype showed evidence of association with disease. These data suggest that any effect of CTLA-4 on multiple sclerosis susceptibility is likely to be very small
Torque magnetometry studies of new low temperature metamagnetic states in ErNi_{2}B_{2}C
The metamagnetic transitions in single-crystal ErNiBC have been
studied at 1.9 K with a Quantum Design torque magnetometer. The critical fields
of the transitions depend crucially on the angle between applied field and the
easy axis [100]. Torque measurements have been made while changing angular
direction of the magnetic field (parallel to basal tetragonal -planes) in a
wide angular range (more than two quadrants). Sequences of metamagnetic
transitions with increasing field are found to be different for the magnetic
field along (or close enough to) the easy [100] axis from that near the hard
[110] axis. The study have revealed new metamagnetic states in ErNiBC
which were not apparent in previous longitudinal-magnetization and neutron
studies.Comment: 3 pages (4 figs. incl.) reported at 52th Magnetism and Magnetic
Materials Conference, Tampa, Florida, USA, November 200
Efficient out-coupling of high-purity single photons from a coherent quantum dot in a photonic-crystal cavity
We demonstrate a single-photon collection efficiency of from
a quantum dot in a low-Q mode of a photonic-crystal cavity with a single-photon
purity of recorded above the saturation power. The high
efficiency is directly confirmed by detecting up to kilocounts per
second on a single-photon detector on another quantum dot coupled to the cavity
mode. The high collection efficiency is found to be broadband, as is explained
by detailed numerical simulations. Cavity-enhanced efficient excitation of
quantum dots is obtained through phonon-mediated excitation and under these
conditions, single-photon indistinguishability measurements reveal long
coherence times reaching ns in a weak-excitation regime. Our work
demonstrates that photonic crystals provide a very promising platform for
highly integrated generation of coherent single photons including the efficient
out-coupling of the photons from the photonic chip.Comment: 13 pages, 8 figures, submitte
Solar Irradiance Variability is Caused by the Magnetic Activity on the Solar Surface
The variation in the radiative output of the Sun, described in terms of solar
irradiance, is important to climatology. A common assumption is that solar
irradiance variability is driven by its surface magnetism. Verifying this
assumption has, however, been hampered by the fact that models of solar
irradiance variability based on solar surface magnetism have to be calibrated
to observed variability. Making use of realistic three-dimensional
magnetohydrodynamic simulations of the solar atmosphere and state-of-the-art
solar magnetograms from the Solar Dynamics Observatory, we present a model of
total solar irradiance (TSI) that does not require any such calibration. In
doing so, the modeled irradiance variability is entirely independent of the
observational record. (The absolute level is calibrated to the TSI record from
the Total Irradiance Monitor.) The model replicates 95% of the observed
variability between April 2010 and July 2016, leaving little scope for
alternative drivers of solar irradiance variability at least over the time
scales examined (days to years).Comment: Supplementary Materials;
https://journals.aps.org/prl/supplemental/10.1103/PhysRevLett.119.091102/supplementary_material_170801.pd
Reconstruction of spectral solar irradiance since 1700 from simulated magnetograms
We present a reconstruction of the spectral solar irradiance since 1700 using
the SATIRE-T2 (Spectral And Total Irradiance REconstructions for the Telescope
era version 2) model. This model uses as input magnetograms simulated with a
surface flux transport model fed with semi-synthetic records of emerging
sunspot groups. We used statistical relationships between the properties of
sunspot group emergence, such as the latitude, area, and tilt angle, and the
sunspot cycle strength and phase to produce semi-synthetic sunspot group
records starting in the year 1700. The semisynthetic records are fed into a
surface flux transport model to obtain daily simulated magnetograms that map
the distribution of the magnetic flux in active regions (sunspots and faculae)
and their decay products on the solar surface. The magnetic flux emerging in
ephemeral regions is accounted for separately based on the concept of extended
cycles whose length and amplitude are linked to those of the sunspot cycles
through the sunspot number. The magnetic flux in each surface component
(sunspots, faculae and network, and ephemeral regions) was used to compute the
spectral and total solar irradiance between the years 1700 and 2009. This
reconstruction is aimed at timescales of months or longer although the model
returns daily values. We found that SATIRE-T2, besides reproducing other
relevant observations such as the total magnetic flux, reconstructs the total
solar irradiance (TSI) on timescales of months or longer in good agreement with
the PMOD composite of observations, as well as with the reconstruction starting
in 1878 based on the RGO-SOON data. The model predicts an increase in the TSI
of 1.2[+0.2, -0.3] Wm-2 between 1700 and the present. The spectral irradiance
reconstruction is in good agreement with the UARS/SUSIM measurements as well as
the Lyman-alpha composite.Comment: 13 pages, 10 figure
Relations between entanglement, Bell-inequality violation and teleportation fidelity for the two-qubit X states
Based on the assumption that the receiver Bob can apply any unitary
transformation, Horodecki {\it et al.} [Phys. Lett. A {\bf 222}, 21 (1996)]
proved that any mixed two spin-1/2 state which violates the Bell-CHSH
inequality is useful for teleportation. Here, we further show that any X state
which violates the Bell-CHSH inequality can also be used for nonclassical
teleportation even if Bob can only perform the identity or the Pauli rotation
operations. Moreover, we showed that the maximal difference between the two
average fidelities achievable via Bob's arbitrary transformations and via the
sole identity or the Pauli rotation is 1/9.Comment: 5 pages, to be published in "Quantum Information Processing
Cerebellar cortical AMPA/kainate receptor blockade prevents performance of classically conditioned nictitating membrane responses
Classical conditioning of the nictitating membrane-eye blink response of rabbits is a simple form of associative motor learning. Lesion studies have shown that performance of learned responses is dependent on the cerebellum, but they have not shown whether there is storage of memories within the cerebellum or distinguished the roles of the cerebellar cortex and nuclei. Reversible inactivations of the cerebellar nuclei have directly implicated the cerebellum in the acquisition of nictitating membrane conditioning, but previously the cerebellar cortex has not been reversibly inactivated to assess its contribution to the performance or acquisition of conditioned responses. Here we use the water-soluble disodium salt of 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) reversibly to block cerebellar cortical AMPA-kainate receptors in lobule HVI and quantitative autoradiography to map its distribution. Conditioned responses are completely, but reversibly, abolished for 10-60 min depending on the concentration of the CNQX infusion and its location within HVI. Zebrin immunohistochemistry was used to define the optimal cortical infusion site that, we suggest, corresponds to the location of the eye blink control regions. We confirm that areas in HVI are essential for the expression of classically conditioned nictitating membrane responses, and we establish a method to analyze the role of cerebellar cortex in the acquisition of this form of motor learning
Ellipsometric measurements of the refractive indices of linear alkylbenzene and EJ-301 scintillators from 210 to 1000 nm
We report on ellipsometric measurements of the refractive indices of LAB-PPO,
Nd-doped LAB-PPO and EJ-301 scintillators to the nearest +/-0.005, in the
wavelength range 210-1000 nm.Comment: 7 pages, 4 figure
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