(2S,3R)-tert-Butyl N-[4-(N-benzyl-4-fluoro­benzene­sulfonamido)-3-hy­droxy-1-phenyl­butan-2-yl]carbamate

In the title mol­ecule, C28H33FN2O5S, the mean plane about the tertiary amine group (sum of the angles subtended at the sp 2-hybridized N atom = 359.7°) forms a dihedral angle of 16.66 (6)° with the phenyl ring adjacent to the carbamate group. The sulfonamide benzene ring and the hy­droxy group lie to either side of the C2NS plane, whereas the benzyl­phenyl (connected to the N atom) and carbamate substituents lie to the other side. Supra­molecular layers propagating in the ac plane are found in the crystal, linked by hy­droxy–sulfonamide O—H⋯O and carbamate–carbamate N—H⋯O hydrogen bonds along with C—H⋯O and C—H⋯π inter­actions

New routes towards reutericyclin analogues

A range of N-acylpyrrolo[3,4-c]isoxazoles and derived N-5 acyltetramides has been prepared via a nitrile oxide dipolar cycloaddition approach, as analogues of the acyltetramic acid metabolite reutericyclin, of interest for their antibiotic potential against Gram-positive bacteria including hospital-acquired infections of resistant Clostridium difficile

Evaluation of Analogs of Reutericyclin as Prospective Candidates for Treatment of Staphylococcal Skin Infections▿

The potential for reutericyclin derivatives to be used as topical antibiotics to treat staphylococcal skin infections was investigated. All reutericyclins inhibited the growth of clinical isolates of drug-resistant Staphylococcus aureus. Unlike the standard topical agent mupirocin, most reutericyclin derivatives eradicated staphylococcal biofilms. Moreover, two compounds formulated in hydrophilic petrolatum (10%, wt/wt) were efficacious in treating S. aureus superficial skin infections in mice. These data exemplify the prospect of developing reutericyclins as new topical antibiotics

Exploring Collaborations

With the recent approval by the Accreditation Council for Pharmacy Education (ACPE) for the pre accreditation status, Sullivan University College of Pharmacy will welcome the inaugural class of students in July 2008. The college offers a three year professional graduate program leading to a Doctor of Pharmacy (Pharm.D.) degree. There are more than 18 faculty members with expertise in various fields such as Pharmaceutical Technology, Physical Pharmacy, Microbiology, Biotechnology, Biochemistry, Pharmacology, Pharmacokinetics, clinical practices in various settings, and collaborative research. The college is developing over 3000 sq. ft. of laboratory space as well as developing research facilities. The faculty have expertise in various aspects of the pharmaceutical business including pre formulation studies, formulation and characterization of drug delivery systems, nano drug delivery systems (especially nano dispersions and nano carriers), polymeric drug delivery systems, microbiological evaluations, clinical studies, nutraceutical formulations and applications, and others. This poster describes the achievements of the college of pharmacy in the last year as well as discusses the expertise of its faculty