An HMM-Like Dynamic Time Warping Scheme for Automatic Speech Recognition

In the past, the kernel of automatic speech recognition (ASR) is dynamic time warping (DTW), which is feature-based template matching and belongs to the category technique of dynamic programming (DP). Although DTW is an early developed ASR technique, DTW has been popular in lots of applications. DTW is playing an important role for the known Kinect-based gesture recognition application now. This paper proposed an intelligent speech recognition system using an improved DTW approach for multimedia and home automation services. The improved DTW presented in this work, called HMM-like DTW, is essentially a hidden Markov model- (HMM-) like method where the concept of the typical HMM statistical model is brought into the design of DTW. The developed HMM-like DTW method, transforming feature-based DTW recognition into model-based DTW recognition, will be able to behave as the HMM recognition technique and therefore proposed HMM-like DTW with the HMM-like recognition model will have the capability to further perform model adaptation (also known as speaker adaptation). A series of experimental results in home automation-based multimedia access service environments demonstrated the superiority and effectiveness of the developed smart speech recognition system by HMM-like DTW

Comparison of Certain Structural Properties Among 3-Ply, 4-Ply and 5-Ply, 1/2-Inch Southern Pine Plywood Sheathing

An evaluation of three constructions 3-ply, 4-ply and 5-ply, 1/2-inch-thick southern yellow pine plywood sheathing as subfloor and roof was made. The evaluation considered only flexural properties, panel shear properties and dimensional stability in relation to panel cost, though other properties are recognized as being important too.Among the three constructions considered, the 3-ply can support higher flexural loads and deflect less as subflooring than can the 4-ply and 5-ply constructions when panels used with face grain orientation parallel to span (perpendicular to the direction of joists). Specifically, at 16-inch spans, flexural strength and stiffness of 3-ply panels are approximately 8% higher than those of 4-ply panels while the manufacturing cost of 3-ply plywood is approximately 5-8% less than the manufacturing cost of 4-ply.Although the 3-ply construction exhibits significantly larger dimensional changes than the two other constructions, it appears that would not create any trouble if used as sub-flooring, since changes of moisture conditions in modern housing are not large enough to produce appreciable internal stresses

Developments of Machine Learning Schemes for Dynamic Time-Wrapping-Based Speech Recognition

This paper presents a machine learning scheme for dynamic time-wrapping-based (DTW) speech recognition. Two categories of learning strategies, supervised and unsupervised, were developed for DTW. Two supervised learning methods, incremental learning and priority-rejection learning, were proposed in this study. The incremental learning method is conceptually simple but still suffers from a large database of keywords for matching the testing template. The priority-rejection learning method can effectively reduce the matching time with a slight decrease in recognition accuracy. Regarding the unsupervised learning category, an automatic learning approach, called "most-matching learning, " which is based on priority-rejection learning, was developed in this study. Most-matching learning can be used to intelligently choose the appropriate utterances for system learning. The effectiveness and efficiency of all three proposed machine-learning approaches for DTW were demonstrated using keyword speech recognition experiments

Effects of dust sources on dust attenuation properties in IllustrisTNG galaxies at z∼7z\sim 7

Dust emission from high-redshift galaxies gives us a clue to the origin and evolution of dust in the early Universe. Previous studies have shown that different sources of dust (stellar dust production and dust growth in dense clouds) predict different ultraviolet (UV) extinction curves for galaxies at $z\sim 7$ but that the observed attenuation curves depend strongly on the geometry of dust and star distributions. Thus, we perform radiative transfer calculations under the dust-stars geometries computed by a cosmological hydrodynamic simulation (IllustrisTNG). This serves to investigate the dust attenuation curves predicted from `realistic' geometries. We choose objects with stellar mass and star formation rate appropriate for Lyman break galaxies at $z\sim 7$. We find that the attenuation curves are very different from the original extinction curves in most of the galaxies. This makes it difficult to constrain the dominant dust sources from the observed attenuation curves. We further include infrared dust emission in the analysis and plot the infrared excess (IRX)-UV spectral slope ($\beta$) diagram. We find that different sources of dust cause different IRX-$\beta$ relations for the simulated galaxies. In particular, if dust growth is the main source of dust, a variation of dust-to-metal ratio causes a more extended sequence with smaller IRX in the IRX-$\beta$ diagram. Thus, the comprehensive analysis of the abundances of dust and metals, the UV slope, and the dust emission could provide a clue to the dominant dust sources in the Universe.Comment: 11 pages, 6 figures, accepted for publication in MNRA

Critical quality attributes (CQAs) of a therapeutic antibody produced from integrated continuous bioprocessing

The integrated continuous bioprocess provides an innovative way to produce protein drugs with flexibility and efficiency. However, during the long-term cultivation and complicated production, how to ensure the process stability and product quality is critically important. In this study, the monoclonal antibody (mAb) was produced in a bioreactor operated in a perfusion mode utilizing the ATF cell retention system for up to 32 days. The 2L harvest per day starting at day 10 was continuously purified using the 3-column periodic counter-current (PCC) chromatography system. The first protein A capture purification was performed with the dynamic binding capacity of 50% breakthrough around 60 mg mAb/mL of resin (vs 20 mg/mL resin for batch purification) for 120 cycles or 360 column operations followed by a polishing step of mixed mode chromatography for 20 cycles. The process and quality attributes were monitored daily. The results demonstrate consistency in both the purification process and the mAb qualities (in the aspects of product integrity, aggregates, and glycan profile) between PCC and batch purifications. Culture-related charge heterogeneity was observed accompanied by an increase of bioreactor harvest time using both batch and PCC purification processes. In addition, the impurities such as endotoxin and HCP were also monitored while under this high capacity utilization of chromatography resins. By sharing the insights of process and quality attributes, we hope to provide better understanding on the process-related heterogeneity between batch and continuous production and/or purification