Hazard ratios of dementia stratified by the period between the last hypnotic prescription and the dementia diagnosis.

<p>Abbreviations: CI, confidence interval; HR, hazard ratio.</p><p>All models are analyzed by Cox regression adjusted for age, sex, hypertension, diabetes, hyperlipidemia, and stroke.</p>*<p>Current: prescription of hypnotics ended within 30 days before dementia index date; previous: prescription ended 31 to 90 days before dementia index date; remote: prescription ended 91 days or more before dementia index date.</p

Hazard ratios of dementia in patients with and without hypnotic usage stratified by categories of hypnotics, half-lives of hypnotics and doses of hypnotics.

<p>Abbreviations: BZD, benzodiazepine; CI, confidence interval; HR, hazard ratio.</p><p>All models are analyzed by Cox regression adjusted for hypertension, diabetes, hyperlipidemia, and stroke.</p>*<p>Low: 7 to 30 defined daily dose (DDD) per year; medium: 31 to 90 DDD per year; high: at least 91 DDD per year.</p

Characteristics of subjects with insomnia and hypnotic use (N = 5693).

<p>Abbreviation: BZD, benzodiazepine.</p>#<p>There were 273 patients (5.76%) switched from short-acting to intermediate-acting (N = 199) or long-acting (N = 74) and 51 patients (5.39%) switched from intermediate-acting to long-acting hypnotics.</p>*<p>Low: 7 to 30 defined daily dose (DDD) per year; medium: 31 to 90 DDD per year; high: at least 91 DDD per year.</p>$<p>Additional included subjects.</p><p>+ Current: prescription of hypnotics ended within 30 days before dementia index date; previous: prescription ended 31 to 90 days before dementia index date; remote: prescription ended 91 days or more before dementia index date.</p

Hazard ratios of dementia in patients with and without hypnotic usage stratified by age and sex.

<p>Abbreviations: CI, confidence interval; HR, hazard ratio.</p><p>All models are analyzed by Cox regression adjusted for hypertension, diabetes, hyperlipidemia, and stroke.</p

Comparison of subjects with and without hypnotic use^*.

<p>Abbreviation: IQR, interquartile range.</p>*<p>Data are number (percentage) except where indicated.</p><p>+Group comparisons by the chi-square test.</p

Odds ratio values of migraine, including independent variables.

<p>CI, confidence interval.</p

Demographic and clinical characteristics of endometriosis patients and controls.

<p>SD, standard deviation.</p