1 research outputs found
Solvent-Triggered Crystallization of Polymorphs Studied in Situ
The crystallization of a highly polymorphic
compound was studied
in situ by combined time-resolved X-ray diffraction and Raman spectroscopy.
Any influences of solid surfaces, temperature, and humidity on the
crystallization were omitted by the use of a specially designed acoustic
levitator. Investigations of polymorphic phase transitions during
the crystallization process in different solvents allowed a structure
assignment from first crystalline assemblies to final crystalline
form. For the first time, it was possible to yield pure phases of
selected polymorphs of the model compound ROY (5-methyl-2-[(2-nitrophenyl)amino]-3-thiophenecarbonitrile)
directly from solution. The influence of the solvent on the final
products and transient phases during the crystallization process was
elucidated