390 research outputs found
Experimental verification of a wireless sensing and control system for structural control using MR dampers
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2007
- Field of study
The performance aspects of a wireless ‘active’ sensor, including the reliability of the wireless communication channel for real-time data delivery and its application to feedback structural control, are explored in this study. First, the control of magnetorheological (MR) dampers using wireless sensors is examined. Second, the application of the MR-damper to actively control a half-scale three-storey steel building excited at its base by shaking table is studied using a wireless control system assembled from wireless active sensors. With an MR damper installed on each floor (three dampers total), structural responses during seismic excitation are measured by the system's wireless active sensors and wirelessly communicated to each other; upon receipt of response data, the wireless sensor interfaced to each MR damper calculates a desired control action using an LQG controller implemented in the wireless sensor's computational core. In this system, the wireless active sensor is responsible for the reception of response data, determination of optimal control forces, and the issuing of command signals to the MR damper. Various control solutions are formulated in this study and embedded in the wireless control system including centralized and decentralized control algorithms. Copyright © 2007 John Wiley & Sons, Ltd.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/56121/1/682_ftp.pd
Robust estimation of bacterial cell count from optical density
- Author
- Aarnio Tiu
- Aaron Leow Chung Yong
- Abbas Anser
- Abduraimova Aiganym
- Abraham Doris
- Acar Beliz Leyla
- Acosta Joaquin
- Adler Nina
- Adulyanukosol Natthawut
- Agena Ejouan
- Agena Ethan
- Aggarwal Priya
- Aguirre Adriana Lizeth Rubio
- Ahlgren Christopher
- Ahuja Janvi
- Aizik Dror
- Akbary Mina
- Akinfenwa Akinwumi
- Akingbesote Ngozi D.
- Akova Umut
- Aldo Ferdinan
- Alexopoulos Ioannis
- Allen Lucy
- Alonso Alejandro
- Altarawneh Dina
- Alvarado Andres Benjamin Sanchez
- Ambre Sanika
- Ameziane Annissa
- Amheine Khadija
- Amin Ihya Fakhrurizal
- Amir Sayeda Sakina
- Amstel Chiel van
- An Yongyan
- Anand Nithishwer Mouroug
- Ananthakrishnan Sathvik
- Anderson Karl
- Angel Sagi
- Annem Vidhya
- Anson Chung Tsun Ho
- Anwar Mariam
- Appel Alana
- Araya Lucas
- Armstrong Alexander
- Arora Neha
- Arora Vasu
- Arruda Beck
- Ashwin F Amal Jude
- Astapenka Artur
- Astles Ben
- Astorino Gabe
- Aubry Celine
- Avileli Rebecca
- Azad Mahnaz Sabeta
- Babar Rehmat
- Babu Priyanka
- Badalli Turan
- Badash Lior
- Baichman-Kass Amichai
- Baldwin Geoff S.
- Baltensperger Oliver Andreas
- Bao Guanke
- Bao Minyue
- Baronaite Ugne
- Barrat Leon Michael
- Barrington Seth
- Barshap Alon
- Bartzoka Natalia
- Basu Anubhav
- Basulto Cynthia
- Bath Scott
- Battina Rohith
- Bauersachs Daniel
- Beal Jacob
- Beale Renee
- Beard Eleanor
- Beck Selina
- Becker Evan
- Benavides Samantha Ayde Pena
- Bennis Nicole
- Bete Anna
- Bhatt Darshak
- Bhowmick Shilpa
- Bian Weixin
- Bijman Eline Yafele
- Bindt Felix
- Blas Karla Soto
- Bo Tang
- Boada Yadira
- Boer Meine
- Bohner Ariel
- Borovko Irina
- Bott Amie
- Bouwmeester Susan
- Bowman Kyle
- Boxem Mike
- Boxuan Cheng
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- Boyer Jess
- Brasas Valentas
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- Briand William
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- Browne Emily
- Buckley-Taylor Russell
- Budhan Stephanie
- Buller Lisa
- Burckhardt Nele
- Burgland Zachary
- Burns Frank
- Burridge Matt
- Burud Hanna Nedreberg
- Buson Felipe Xavier
- Butterfield Tom
- Byagathvalli Gaurav
- Byatt Gabriel
- Byun Sumin
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- Cai Fu
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- Caldwell Sarah
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- Camille Monteil
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- Cao Qinhao
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- Castillo Nora Esther Torres
- Castillo Sandra
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- Chater Dounia
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- Chavez Benjamin
- Chavez Francisco
- Chehade Ibrahim
- Chen Carmen
- Chen Chih-Chiang
- Chen Ching-Wei
- Chen Janice
- Chen Junhong
- Chen Junyang
- Chen Junyu
- Chen Pei-Hong
- Chen Ryan
- Chen Weixuan
- Chen Yan
- Chen Yi-Cian
- Chen Yifei
- Chen Zhuoyang
- Cheng Cheng
- Cheng Haolun
- Cheng Hsuan
- Cheng Yu-Hong
- Cheng Yu-Hsuan
- Chenxi Liang
- Cherupalla Arjun
- Chi Jordi
- Chi Shumei
- Chiang Jason
- Chiang Woody
- Ching Lai Tsz
- Ching Lam Kai
- Ching Law Hiu
- Ching Luk Hau
- Chinnathambi Sathivel
- Cho Sungwoo
- Choi Lee Sze
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- Chou Ryan
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- Cifuentes Rodrigo Hernandez
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- Clapper Jude
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- Dai Leijie
- Dalangin Rochelin
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- Daniels Lea
- Das Neves Laura
- Das Diptatanu
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- De Silva Nimaya
- Deb Shalini S.
- Deepak Kumar S.
- Deibel Emilie
- Dejoie Julianne
- Dejoux Alice
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- Delgadillo Sabrina
- Delhomme Jean
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- Deng Nian Ruei
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- Despres Philippe C.
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- Diaz Fernanda
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- Dingyue Tang
- Dirven Yvette
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- Do Stephanie
- Dogra Arushi
- Dominguez Viana Isabel Perez
- Dong Dongyang
- Dong Haitao
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- Dong Shan
- Dong Shan
- Dong Shan
- Dong Shangzhi
- Dong Shangzhi
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- Doyle Shannon
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- Dubuc Emilien
- Dunstan Izzy
- Dusseaux Theodore A.
- Dvorkin Steve
- Edelmayer Marco
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- Eijkens Bruno
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- El Moubayed Yorgo
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- Elikan Max
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- Elsa Yeung Hoi Lam
- Emilov Kristian
- Espinoza Diego
- Evans Rhys
- Faidh Mohammed
- Falgenhauer Elisabeth
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- Farny Natalie
- Farny Natalie G.
- Farrell Jennifer
- Fassler Jan
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- Fernandez Cesar Ibrahym Rodriguez
- Fierro Daniela Olono
- Figueroa Ana Cristina
- Figueroa Jose Arnulfo Juarez
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- Filzen Rachael
- Fischer Matthew
- Fitzgerald Kevin
- Fitzgerald Liza
- Flores Vinicius
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- Freire Paulo J. C.
- Friedman Yonatan
- Frohlich Lisa
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- Giannoula Yvoni
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- Glockner Eleanor
- Goenka Anushya
- Goetz Marley
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- Gokul [NO FIRST NAME IN SCOPUS]
- Gonzalo Gonzalo Saiz
- Goodson Michael
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- Raut Sandeep
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- Reaney Bethany
- Rebello Alex
- Rege Mayuri
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- Resendiz Armando Cortes
- Reshamwala Shamlan M. S.
- Rettedal Neil
- Ribeiro Nathan Vinicius
- Ries Anna
- Rigon Luca
- Ripp Steven
- Ritmejeris Justas
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- Rivera Mario Loya
- Roberts Luc
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- Rodriguez Guillermo Fernandez
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- Rolfsnes Rebekka Rekkedal
- Romeo Yves
- Rong Ziyue
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- Rouleau Francois D.
- Ruhnau Johannes
- Ruhnau Johannes
- Run Zhouyan
- Ruscher David
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- Sabuwala Burhanuddin
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- Shi Wei
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- Shinde Mousami
- Shkolnikov Irene
- Shola Chemay
- Shuan Cheah Matthew Yun
- Shuan Yun
- Shulun [NO FIRST NAME IN SCOPUS]
- Shuyu Shi
- Sia Nympha Elisa M.
- Siemer Jessica
- Sillner Cassandra
- Silva Bruna Fernandes
- Silva Dewuni De
- Simona Magda Faijes
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- Xu Xin
- Xu Yinsong
- Xuan Chen Zi
- Xue Fang
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- Xun Shu
- Yadav Ravineet
- Yadav Yash
- Yadi Liu
- Yan Calvin
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- Yan Han
- Yan Hongfa
- Yan Qingyan
- Yan Tsui Shing
- Yan Yeung Wing
- Yan Yining
- Yang Chao
- Yang Chenghao
- Yang Chuyi
- Yang Fan
- Yang Fuqiang
- Yang Hanyeol
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- Yang Jianzhe
- Yang Jindian
- Yang Jinshu
- Yang Jun
- Yang Leyi
- Yang Ruofan
- Yang Shaobo
- Yang Shuting
- Yang Xilin
- Yang Yuchen
- Yang Zhuoyi
- Yang Zisang
- Yang Zon En
- Yao Andrew
- Yarbrough Hayden
- Yaxi Zhang
- Ye Yusheng
- Yee Chong Yuk
- Yeh Chan-yu
- Yehouessi Tamara
- Yeliseyeva Hanna
- Yesley Phillip
- Yeung Wong Tsz
- Yifan Li
- Yihang Qiu
- Yiming Quan
- Yin Jiacheng
- Yin Lee Ka
- Yin Xianqi
- Yong Nur Liyana Binte Ayub Ow
- Yong Zhangxiang
- Yongjie Lin
- Yoo Hojun
- Yoon Soohyun
- You Jaewon
- Young Cam
- Yu Haimeng
- Yu Jiacheng
- Yu Kai-Chiang
- Yu Liuhong
- Yu Tam Chi
- Yu Wenfei
- Yu Yuen Wai
- Yuan Hetian
- Yuan Long
- Yuan Xing
- Yuan Zhe
- Yuanxu Jiang
- Yucheng Chen
- Yue Qing
- Yueyi Li
- Yuhan Cheng
- Yujie Peng
- Yun Yejie
- Yung Jay
- Yutong Pan
- Zadeh Daniel
- Zamora Alejandro Robles
- Zanoni Paul
- Zanotti Violetta
- Zeng Chenxu
- Zeng Yuanhong
- Zepeng Xu
- Zerva Anastasia
- Zhan Yang
- Zhang Alice
- Zhang Bonan
- Zhang Jianxiang
- Zhang Jige
- Zhang Jinhan
- Zhang Kaida
- Zhang Kecheng
- Zhang Qian
- Zhang Shuyan
- Zhang Tianyi
- Zhang Wanli
- Zhang Xianyin
- Zhang Xinyu
- Zhang Yihao
- Zhang Yuanzhen
- Zhang Yunqian
- Zhang Zixuan
- Zhao Nannan
- Zhao Peng
- Zhao Tianyan
- Zhao Wenxue
- Zhao Yihang
- Zhaoting Li
- Zhecheng Huang
- Zheng Daniel
- Zheng Jiyang
- Zhiwei Song
- Zhong Yanling
- Zhou Hanmi
- Zhou Jiajie
- Zhou Jianan
- Zhou Rui
- Zhou Shuyao
- Zhou Xuanhao
- Zhou Yanjun
- Zhou Yi
- Zhou Yinchi
- Zhou Yineng
- Zhou Yuezhang
- Zhou Yuxin
- Zhou Zhiyu
- Zhu Chushu
- Zhu Ke
- Zhu Xueqian
- Zi Lihan
- Zilinskaite Nemira
- Zimmermann Andreas
- Zimmermann Jennifer
- Zirong Zeng
- Ziwei Zhou
- Ziyi Zhao
- Zorrilla Francisco
- Zou Jiahua
- Zukauskaite Kristina
- Zulueta Patricia
- Zvirblyte Justina
- Publication venue
- Publication date
- 01/01/2020
- Field of study
Optical density (OD) is widely used to estimate the density of cells in liquid culture, but cannot be compared between instruments without a standardized calibration protocol and is challenging to relate to actual cell count. We address this with an interlaboratory study comparing three simple, low-cost, and highly accessible OD calibration protocols across 244 laboratories, applied to eight strains of constitutive GFP-expressing E. coli. Based on our results, we recommend calibrating OD to estimated cell count using serial dilution of silica microspheres, which produces highly precise calibration (95.5% of residuals <1.2-fold), is easily assessed for quality control, also assesses instrument effective linear range, and can be combined with fluorescence calibration to obtain units of Molecules of Equivalent Fluorescein (MEFL) per cell, allowing direct comparison and data fusion with flow cytometry measurements: in our study, fluorescence per cell measurements showed only a 1.07-fold mean difference between plate reader and flow cytometry data
Hysterectomies are associated with an increased risk of osteoporosis and bone fracture: A population-based cohort study.
- Author
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/01/2020
- Field of study
AimThis study investigated the risk of osteoporosis or bone fractures (vertebrae, hip and others) in hysterectomized women in Taiwan.Materials and methodsThis is a retrospective population-based cohort study from 2000 to 2013. Women aged ≥30 years who underwent hysterectomy between 2000 and 2012 were included in this study. The comparison group was randomly selected from the database with a 1:4 matching with age and index year. Incidence rate and hazard ratios of osteoporosis and bone fracture between hysterectomized women and the comparison group were calculated. Cox proportional hazard regressions were used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs).ResultsWe identified 9,189 hysterectomized women and 33,942 age-matched women without a hysterectomy. All women were followed for a median time of about 7 years. The adjusted hazard ratio (aHR) of subsequent osteoporosis or bone fracture was higher in the hysterectomy women (2.26, 95% confidence interval [CI] = 2.09-2.44) than in the comparison group. In the subgroup analysis, oophorectomy and estrogen therapy increase the risk of osteoporosis or fracture in both groups. Regarding the fracture site, the aHR of vertebral fracture (4.92, 95% CI = 3.78-6.40) was higher in the hysterectomized women than in the comparison group. As follow-up time increasing, the aHR of vertebral fracture in hysterectomized women were 4.33 (95% CI = 2.99-6.28), 3.89 (95% CI = 2.60-5.82) and 5.42 (95% CI = 2.66-11.01) for ConclusionsIn conclusion, we found that hysterectomized women might be associated with increased risks of developing osteoporosis or bone fracture
Indole-3 acetic acid increased risk of impaired cognitive function in patients receiving hemodialysis
- Author
- Adesso
- Bahn
- Bugnicourt
- Cheng-Sheng Chen
- Chillon
- Collins
- Coppen
- Costa
- Deguchi
- Dou
- Duranton
- Evenepoel
- Fadili
- Fernandez-Prado
- Florens
- Folstein
- Foster
- Furukawa
- Gondouin
- Hedayati
- Hei-Hwa Lee
- Hsieh
- Hsieh
- Jourde-Chiche
- Jung
- Karu
- Knopman
- Kurella
- Kurella Tamura
- Kurella Tamura
- Lin
- Mei-Chuan Kuo
- Mutsaers
- Mwenya Mubanga
- Nasreddine
- Odagiri
- Ohtsuki
- O’Lone
- Ping-Hsun Wu
- Po-Lin Kuo
- Sarnak
- Sato
- Schoots
- Schroeder
- Shang-Jyh Hwang
- Teng
- Tiffin-Richards
- Vanholder
- Watanabe
- Watanabe
- Yeh
- Yi-Ting Lin
- Yi-Wen Chiu
- Zheng
- Zimmerman
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
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- Chou Kang-Ju
- Chowdhury Paramit
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- Chrysochou Constantina
- Chukwu Chukwuma
- Chun Ka Yeong
- Chung Wookyung
- Cieniawski Dominik
- Claisse Guillaume
- Clayton Philip
- Cleary Catalina Martín
- Clement Nisha
- Coates Toby
- Cogno Chiara
- Colla Loredana
- Collins Michael
- Colucci Marco
- Combe Christian
- Comi Nicolino
- Comunale Roderick
- Contreras Gabriel
- Cooper Bruce
- Coppock Gaia
- Costa Ana Cortesão
- Costanzi Stefano
- Cozzolino Mario
- Crail Susan
- Cunha Liliana
- Curry Elizabeth
- Dai Tiane
- Daina Erica
- Daneshvari Sam
- Dasgupta Indranil
- DaSilva Louise
- Davidson Robert
- De Bhailis Aine Maire
- de Précigout Valérie
- Decupere Marc
- Delmas Yahsou
- Deodato Francesca
- Dhaun Neeraj
- Dhaygude Ajay
- Dhelaria Ranjit
- Di Maio Federica
- Diezhandino Maria Angeles Goicoechea
- Dika Zivka
- Dinic Miriana
- Dittmer Ian
- Diva Ulysses A
- Dobre Mirela
- Doctor Gabriel
- Donati Gabriele
- Doubel Peter
- Douthit Nicole
- Draganova Diliana
- Drexler Yelena
- Drinkovic Martin
- Drinovska Klara
- Dudreuilh Caroline
- Dumond Clement
- Durlen Ivan
- Dussol Bertrand
- Encarnacion Montserrat Diaz
- Endre Zoltan
- Enrique Jorge
- Eqbal Yusuf
- Erlich Jonathan
- Esposito Ciro
- Esposito Vittoria
- Fakih Faisal
- Fang Hua-Chang
- Farinha Ana
- Fearday Aaron
- Felgueiras Joana de Sousa Soares
- Felicjanczuk Elzbieta
- Fernandes Adriana
- Fernandes João Carlos
- Fernandes Sara
- Fernandez Jose Luño
- Fernandez Victor
- Fernando Mangalee
- Figueiredo Ana Carolina
- Firre Eric
- Floege Jürgen
- Flossmann Oliver
- Floyd Lauren
- Fonseca Jose Nuno de Almeida Agapito
- Fonseca Nuno
- Foote Celine
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- Forcen Angel
- Fornoni Alessia
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- Fraser Ian
- Fung Ka Shun Samuel
- Furlano Monica
- Furtado Teresa
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- Gangadharan Muralikrishna
- Garcia Fabiola Alonso
- Garcia Olga Gracia
- Garg Gunjan
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- Geara Abdallah
- Geddes Colin
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- Germain Michael
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- Giaroni Francesco
- Giles Harold
- Gillies Alastair
- Gimeno Ana Vilar
- Girardet Annette
- Glaze Jeffrey
- Goh Tze
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- Gomes Ana Marta
- Goncalves Luis Pedro Falcao
- Goncalves Sara
- Gontarek-Kacprzak Julita
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- Ha Jeffrey Tsun Kit
- Hall Amanda
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- Haws Robert
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- Heinrichs Sven
- Henderson Amy
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- Heng Anne-Elisabeth
- Heres Salia Virxinia Pol
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- Ho Tzung-Yo
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- Hsu Bang-Gee
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- Huang Chien-Wei
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- Hyun Young Youl
- Ilmoja Madis
- Inrig Jula K
- Irish Georgina
- Jacob Radu
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- Jain Arunima
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- Jang Hye Ryoun
- Janko Catherine
- Jardine Meg
- Jaskowski Piotr
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- Jelakovic Bojan
- Jeon Junseok
- Jeong Jong Cheol
- Jesudason Shilpanjali
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- Jo Sang-Kyung
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- Julian Bruce
- Jung JiYong
- Jyothinagaram Praveena
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- Kim Myung-Gyu
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- Kim Sunggyun
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- Kimber Cassandra
- Klamm Kathryn
- Koch Annegret
- Koester Eric
- Kohan Donald E
- Kolvald Kulli
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- Santos Iara Da Silva
- Santos Patricia Valerio
- Sargsyan Mari
- Sarnow Franziska
- Sat Sebahat
- Satora Ewa
- Savuk Ana
- Sayer Matthew
- Schlieper Georg
- Schlosser Mandy
- Schmidt-Guertler Hans
- Schockaert Olivier
- Schulte Kevin
- Schulz Lisa
- Selvaskandan Haresh
- Semple David
- Sen Shaundeep
- Seppet Elviira
- Serrano Antonio Galan
- Serre Jean-Emmanuel
- Sevillano Angel
- Shah Sapna
- Shen Yvonne
- Sheridan Brittany
- Shu Kai-Hsiang
- Sightler Ford
- Silva Arnold
- Silva Sónia
- Sinha Smeeta
- Siriwardana Amanda
- Sitas Zvonimir
- Sivo Carmen
- Sizeland Peter
- Sly Cathylee
- Smith Priscilla
- Snow Brian
- Soares Elsa Sofia Quadrado
- Solazzo Andrea
- Solis Elena Gutierrez
- Solomon Laurence
- Song Young Rim
- Sousa Helena
- Spinowitz Bruce
- Stallworthy Elizabeth
- Stamellou Eleni
- Stanczyk Malgorzata
- Stangenberg Stefanie
- Stankovic Marija
- Stankuviene Asta
- Stea Emma Diletta
- Stompor Tomasz
- Storrar Joshua
- Sullivan James
- Sulowicz Wladyslaw
- Suyumova Irina
- Szeto Cheuk Chun
- Sá Helena
- Sánchez de la Nieta Maria Dolores
- Tamarit Esther
- Tan Eddie
- Tan May
- Tang Hon
- Tang Sydney C W
- Tang Sydney Chi Wai
- Teixeira Catarina
- Telling Kadri
- Terrades Natalia Ramos
- Tesar Vladimir
- Tez Didem
- Thervet Eric
- Thibaudin Damien
- Thomas Mark
- Thyagarajan Nikhil
- Tkaczyk Marcin
- Torreggiani Massimo
- Trachtman Howard
- Trillini Matias
- Trimarchi Hernán
- Tsai Jer-Chia
- Tsai Shang-Feng
- Tsai Wan-Chuan
- Tseng Po-Yu
- Tumlin James
- Tumlin James A
- Tung Kuei-Ting
- Turnbull Angus
- Udani Suneel
- Uhlinova Jana
- Unt Kristin
- Urciuolo Federica
- Vanacker An
- Vandewiele Bert
- Vaz Alvaro
- Veermae Kristi
- Viaene Liesbeth
- Vickiene Alvita
- Vigano Sara
- Vila Maria Antonia Munar
- Vilayur Eswari
- Villanueva Caridad Martinez
- Villarroya Cristina Medrano
- Villen Alejandro Soria
- Viramontes Veronica
- Vita Caterina
- Vujcic Dunja
- Wahba Mona
- Wan Susan
- Wang Chih-Hsien
- Warling Xavier
- Waters Gerald
- Waugh Jane
- Weiland Lea
- Weiner Stefan
- Weinreich Thomas
- Werth Stephan Christian
- Wickens Olivia
- Wijeratne Vidu
- Wilder Karen
- Willcocks Lisa
- Williams Allister
- Winiarska Agata
- Wirtz Nikolaus
- Wolf Gunter
- Wolf Lothar
- Wong Muh Geot
- Wong Sze Ho Sunny
- Wong Yick Hei
- Workeneh Biruh
- Wu Hon-Yen
- Wu Ming-Ju
- Wyndham Roger
- Yang Jihyun
- Yang Ju-Yeh
- Yeap Chii
- Yim Ka Fai
- Yong Kenneth
- Yoo Tae-Hyun
- Yoon Songuk
- Yu Tung-Min
- Yue Tak Tai Andrew
- Zakari Michel
- Zakauskiene Urte
- Zaoui Philippe
- Zbrzezniak Justyna
- Zielinska Dorota
- Zizzi Carlotta Federica
- Publication venue
- Publication date
- 01/11/2023
- Field of study
BackgroundSparsentan, a novel, non-immunosuppressive, single-molecule, dual endothelin angiotensin receptor antagonist, significantly reduced proteinuria versus irbesartan, an angiotensin II receptor blocker, at 36 weeks (primary endpoint) in patients with immunoglobulin A nephropathy in the phase 3 PROTECT trial's previously reported interim analysis. Here, we report kidney function and outcomes over 110 weeks from the double-blind final analysis.MethodsPROTECT, a double-blind, randomised, active-controlled, phase 3 study, was done across 134 clinical practice sites in 18 countries throughout the Americas, Asia, and Europe. Patients aged 18 years or older with biopsy-proven primary IgA nephropathy and proteinuria of at least 1·0 g per day despite maximised renin–angiotensin system inhibition for at least 12 weeks were randomly assigned (1:1) to receive sparsentan (target dose 400 mg oral sparsentan once daily) or irbesartan (target dose 300 mg oral irbesartan once daily) based on a permuted-block randomisation method. The primary endpoint was proteinuria change between treatment groups at 36 weeks. Secondary endpoints included rate of change (slope) of the estimated glomerular filtration rate (eGFR), changes in proteinuria, a composite of kidney failure (confirmed 40% eGFR reduction, end-stage kidney disease, or all-cause mortality), and safety and tolerability up to 110 weeks from randomisation. Secondary efficacy outcomes were assessed in the full analysis set and safety was assessed in the safety set, both of which were defined as all patients who were randomly assigned and received at least one dose of randomly assigned study drug. This trial is registered with ClinicalTrials.gov, NCT03762850.FindingsBetween Dec 20, 2018, and May 26, 2021, 203 patients were randomly assigned to the sparsentan group and 203 to the irbesartan group. One patient from each group did not receive the study drug and was excluded from the efficacy and safety analyses (282 [70%] of 404 included patients were male and 272 [67%] were White) . Patients in the sparsentan group had a slower rate of eGFR decline than those in the irbesartan group. eGFR chronic 2-year slope (weeks 6–110) was −2·7 mL/min per 1·73 m2 per year versus −3·8 mL/min per 1·73 m2 per year (difference 1·1 mL/min per 1·73 m2 per year, 95% CI 0·1 to 2·1; p=0·037); total 2-year slope (day 1–week 110) was −2·9 mL/min per 1·73 m2 per year versus −3·9 mL/min per 1·73 m2 per year (difference 1·0 mL/min per 1·73 m2 per year, 95% CI −0·03 to 1·94; p=0·058). The significant reduction in proteinuria at 36 weeks with sparsentan was maintained throughout the study period; at 110 weeks, proteinuria, as determined by the change from baseline in urine protein-to-creatinine ratio, was 40% lower in the sparsentan group than in the irbesartan group (−42·8%, 95% CI −49·8 to −35·0, with sparsentan versus −4·4%, −15·8 to 8·7, with irbesartan; geometric least-squares mean ratio 0·60, 95% CI 0·50 to 0·72). The composite kidney failure endpoint was reached by 18 (9%) of 202 patients in the sparsentan group versus 26 (13%) of 202 patients in the irbesartan group (relative risk 0·7, 95% CI 0·4 to 1·2). Treatment-emergent adverse events were well balanced between sparsentan and irbesartan, with no new safety signals.InterpretationOver 110 weeks, treatment with sparsentan versus maximally titrated irbesartan in patients with IgA nephropathy resulted in significant reductions in proteinuria and preservation of kidney function
Sparsentan in patients with IgA nephropathy: a prespecified interim analysis from a randomised, double-blind, active-controlled clinical trial
- Author
- Aaron Fearday
- Abdallah Geara
- Adam Morris
- Adriana Fernandes
- Adriana Sierra Ochoa
- Aejin Kim
- Agata Winiarska
- Aine Maire De Bhailis
- Ajay Dhaygude
- Alastair Gillies
- Alba Atenza
- Alberto Ortiz Arduan
- Alejandro Soria Villen
- Alessia Fornoni
- Alex Mercer PhD g
- Alexandre Buffet
- Alexandre Karras
- Alfred Rodriguez
- Ali Assefi
- Allister Williams
- Allyson Medina
- Alvaro Vaz
- Alvita Vickiene
- Amanda Hall
- Amanda Mather
- Amanda Siriwardana
- Amar Mahdi
- Amy Henderson
- Amy Hudson
- An Vanacker
- Ana Avila Bernabeu
- Ana Carolina Figueiredo
- Ana Cortesão Costa
- Ana Farinha
- Ana Marta Gomes
- Ana Messias
- Ana Natario
- Ana Perez de Jose
- Ana Savuk
- Ana Vilar Gimeno
- Andrea Cavalli
- Andrea Solazzo
- Andrew Bomback
- Andrew Henderson
- Andrew McNally
- Angel Forcen
- Angel Sevillano
- Angus Ritchie
- Angus Turnbull
- Anna Benesova
- Anna Jander
- Anna Ricchiuto
- Anne Blanchard
- Anne-Elisabeth Heng
- Annegret Koch
- Annette Girardet
- Annie Reynolds
- Annika Adoberg
- Anoushka Krishnan
- Anthony Ting Pong Chan
- Antolina Moreno
- Antonio Galan Serrano
- Aparna Padiyar
- Archana Gautam
- Arksarapuk Jittirat
- Arnold Silva
- Aron Chakera
- Artashes Patrikyan
- Arun Gopu
- Arunima Jain
- Arvind Ponnusamy
- Asghar Chaudhry
- Asha Bailey
- Ashik Hayat
- Ashraf Mikhail
- Asta Auerbach
- Asta Stankuviene
- Aurore Labat
- Bamidele Ajayi
- Bang-Gee Hsu
- Barbara Greco
- Bart Maes
- Bassam Alchi
- Belen Vizcaino Castillo
- Bernd Hohenstein
- Bert Vandewiele
- Bertrand Dussol
- Bhadran Bose
- Bhavna Pandya
- Biruh Workeneh
- Bogna Kwella
- Bojan Jelakovic
- Brad Rovin
- Bradley Nelson
- Brendon Neuen
- Brian Snow
- Britt Newsome
- Brittany Sheridan
- Bruce Baker
- Bruce Cooper
- Bruce Julian
- Bruce Spinowitz
- Camille Lanaret
- Caridad Martinez Villanueva
- Carlos Arias
- Carlos Gonzalez
- Carlotta Federica Zizzi
- Carmelita Marcantoni
- Carmen Sivo
- Carol Pollock
- Carole Philipponnet
- Caroline Dudreuilh
- Cassandra Kimber
- Catalina Martín Cleary
- Catarina Abrantes
- Catarina Almeida
- Catarina Teixeira
- Caterina Vita
- Catherine Janko
- Catherine Masset
- Cathylee Sly
- Celine Foote
- Chaim Charytan
- Chee Kay Cheung
- Chen Peh
- Cheng-Hsu Chen
- Cheuk Chun Szeto
- Chi Kwan Darwin Lam
- Chi-Chih Hung
- Chia-Tien Hsu
- Chiara Cogno
- Chien-Liang Chen
- Chien-Wei Huang
- Chih-Hsien Wang
- Chih-Yang Hsu
- Chii Yeap
- Christian Broyet
- Christian Combe
- Christiane Kettner
- Christine Ayvazyan
- Christophe Mariat
- Christopher Goldsmith
- Christopher Keller
- Chukwuma Chukwu
- Ciro Esposito
- Claire Rigothier
- Clara Barrios
- Clara Garcia Carro
- Clara Pardinhas
- Clarisse Greze
- Clement Dumond
- Clementine Nicolo
- Colin Geddes
- Constantina Chrysochou
- Cristina Medrano Villarroya
- Cyril Garrouste
- Damien Thibaudin
- Dan Pugh
- Dana Kim
- Dana Rizk
- Daniela Lopes
- Dariush Arfaania
- Dariusz Aksamit
- David Fouassier
- David Packham
- David Semple
- Davide Bolignano
- Davide Catucci
- Davina Ngoi Wah Lie
- Daw-Yang Hwang
- Dawn Caster
- Didem Tez
- Diliana Draganova
- Dimitrios Moutzouris
- Dita Maixnerova
- Djuro Plavljanic
- Dominik Cieniawski
- Donald Brandon
- Donald Brandon
- Dong Wan Chae
- Doris Chan
- Dorota Zielinska
- Drasko Pavlovic
- Dubravka Trajbar Kentric
- Dunja Barisic
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- Durga Kanigicherla
- Eamon Mahdi
- Eddie Tan
- Edgar Almeida
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- Emma O'Lone
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- Erika Perez
- Esther Tamarit
- Eswari Vilayur
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- Euan Noble
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- Ewa Satora
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- Francisco de la Prada Alvarez
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- Gabriel Contreras
- Gabriel Doctor
- Gabriele Donati
- Gaia Coppock
- Gary Chi Wang Chan
- Gemma Patella
- Georg Schlieper
- Georgina Irish
- Gerald Appel
- Gerald Waters
- Gert Meeus
- Giuseppe Remuzzi
- Grant Luxton
- Guillaume Claisse
- Guillaume Jeantet
- Gunjan Garg
- Gunter Wolf
- Gustavo Andres Useche Bonilla
- Hajeong Lee
- Han Ro
- Hanna Augustyniak-Bartosik
- Hans Schmidt-Guertler
- Haresh Selvaskandan
- Harold Giles
- Heather Green
- Helen Pilmore
- Helena Marco Rusinol
- Helena Sousa
- Helena Sá
- Helmut Reichel
- Hernán Trimarchi MD b l
- Hesham Mohey
- Hon Tang
- Hon-Yen Wu
- Hoon Young Choi
- Howard Lifland
- Hsien-Fu Chiu
- Hsin-Yu Chen
- Hua-Chang Fang
- Hung-Chun Chen
- Hung-Tien Kuo
- Hung-Yuan Chen
- Hye Ryoun Jang
- Hyeong Cheon Park
- Hyung Wook Kim
- Hyung-seok Lee
- HyunHee Lee
- Ian Chiu
- Ian Dittmer
- Ian Fraser
- Iara Da Silva Santos
- Indranil Dasgupta
- Inga Arune Bumblyte'
- Ingrid Masson
- Ingrid Prkacin
- Irene Agraz Pamplona
- Irina Suyumova
- Isabella Abbasciano
- Isabelle Ayoub
- Ivan Durlen
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- Ivana Mikacic
- Ivica Horvatic
- Ivon Maritza Bobadilla Rico
- Ivon Maritza Bobadilla Rico
- Jae Hyun Chang
- Jafar Ahmed
- Jai Radhakrishnan
- James Sullivan
- James Tumlin
- Jana Uhlinova
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- Jane Waugh
- Janson Leung
- Javad Mojarrab
- Jean-Emmanuel Serre
- Jeffrey Glaze
- Jeffrey Tsun Kit Ha
- Jer-Chia Tsai
- Jerko Barbic
- Jerry Meng
- Ji Yong Jung
- Jigar Kadakia
- Jihyun Yang
- Joana de Sousa Soares Felgueiras
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- Johann Konstantin Herfurth
- Jonathan Ayling-Smith
- Jonathan Barratt
- Jonathan Erlich
- Jonathan Hogan
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- Jong Cheol Jeong
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- Jose Antonio Lopes
- Jose Ballarin
- Jose Carlos de Jesus Barreto
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- Jose Nuno de Almeida Agapito Fonseca
- Josep Miquel Blasco Pelicano
- Joshua Storrar
- João Carlos Fernandes
- Ju-Yeh Yang
- Juan Carbonell
- Jula Inrig MD f
- Julia Piel
- Julita Gontarek-Kacprzak
- Jung Tak Park
- JungEun Lee
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- Jusmin Patel
- Justyna Zbrzezniak
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- Ka Fai Yim
- Ka Shun Samuel Fung
- Ka Yeong Chun
- Kadri Lilienthal
- Kadri Telling
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- Kang-Ju Chou
- Kannaiyan Rabindranath
- Karen Brown
- Karen Wilder
- Karolina Kratka
- Karolina Majstorovic Barac
- Kassem Khalil
- Kathryn Klamm
- Kay Kyaw
- Kellyn McMahon
- Kenneth Yong
- Kerri McGreal
- Kevin Schulte
- Kieran McCafferty
- Kit Chung Jack Ng
- Klara Drinovska
- Kook-Hwan Oh
- Kristi Veermae
- Kristin Unt
- Kshama Mehta
- Kuei-Ting Tung
- Kulli Kolvald
- Kumaradevan Mahadevan
- Kumaradevan Mahadevan
- Kyu-Beck Lee
- Lai Wan Chan
- Lana Gellineo
- Lathika Raakesh
- Laura Ann Kooienga
- Laure Burguet
- Lauren Floyd
- Lauren Heath
- Laurence Solomon
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- Lea Weiland
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- Leticia Perez Lluna
- Lida Maria Rodas Marin
- Liesbeth Viaene
- Liisi Leis
- Liliana Cunha
- Lina Santockiene
- Lisa Schulz
- Lisa Willcocks
- Loredana Colla
- Loreto Gesualdo
- Lorraine Pui Yuen Kwan
- Lothar Wolf
- Louise DaSilva
- Luc Radermacher
- Lucia Del Vecchio
- Lucia Parreira
- Luigi Biancone
- Luis F Quintana
- Luis Pedro Falcao Goncalves
- Machaiah Madhrira
- Madis Ilmoja
- Magdalena Krajewska
- Maggie Ming Yee Mok
- Mai Rosenberg
- Malgorzata Stanczyk
- Mandy Schlosser
- Mangalee Fernando
- Manual Praga
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- Marc Decupere
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- Margret Patecki
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- Maria Angeles Goicoechea Diezhandino
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- Maria Antonieta Azancot Rivero
- Maria Arena
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- Maria Menezes
- Marija Stankovic
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- Marine Livrozet
- Mario Cozzolino
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- Mario Ruiz
- Marius Miglinas
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- Matthias Cassia
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- Mei-Chuan Kuo
- Mei-Fen Pai
- Melissa Cheetham
- Mercedes Gonzalez Moya
- Mercedes Salgueira Lazo
- Mercedes Velo Plaza
- Michael Collins
- Michael Germain
- Michel Zakari
- Michela Musolino
- Michelle N Rheault MD i
- Michelle O'Shaughnessy
- Ming-Ju Wu
- Ming-Shan Chang
- Mingyao Ma
- Mirco Belingheri
- Mirela Dobre
- Miriana Dinic
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- Mohammad Rony
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- Mona Wahba
- Monica Bordoli
- Monica Furlano
- Monica Limardo
- Montserrat Diaz Encarnacion
- Moon Hyoung Lee
- Muh Geot Wong
- Muh Geot Wong PhD m n
- Muralikrishna Gangadharan
- Myung-Gyu Kim
- Narae Joo
- Natalia Allende Burgos
- Natalia Allende Burgos
- Natalia Ramos Terrades
- Nathan Lorde
- Nayan Gowda
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- Nicolino Comi
- Nikhil Thyagarajan
- Nikolaus Wirtz
- Nisha Clement
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- Nishita Parikh
- Noemie Chiche-Jourde
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- Norberto Perico
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- Peter Hollett
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- Philip Clayton
- Philippe Zaoui
- Phillip Madonia
- Piergiorgio Messa
- Pierre-Louis Carron
- Pietro Canetta
- Pietro Napodano
- Piotr Jaskowski
- Po-Tsang Lee
- Po-Yu Tseng
- Pradip Chowdhury
- Praveena Jyothinagaram
- Priscilla Smith
- Prof Brad Rovin MD j
- Prof Charles E Alpers MD d
- Prof Hiddo J L Heerspink PhD a b
- Prof Howard Trachtman MD k
- Prof Irene L Noronha MD h
- Prof Jai Radhakrishnan MD c
- Prof Jonathan Barratt PhD e
- Prof Vlado Perkovic MD b ofor the PROTECT Investigators† Author links open overlay panelEric Alarmartine
- Przemyslaw Miarka
- Rachel Jones
- Radko Komers MD f
- Radu Jacob
- Raffi Minasian
- Rajan Patel
- Rajdeep Gadh
- Ramachandra Patak
- Ranjit Dhelaria
- Rathika Krishnasamy
- Rathika Krishnasamy
- Raul Fernandez Prado
- Richard Lafayette
- Rishi Pruthi
- Ritesh Raichoudhury
- Robert Carroll
- Robert Davidson
- Robert Haws
- Robert Malecki
- Roberta Aliotta
- Rocco Baccaro
- Roderick Comunale
- Roderick Comunale
- Roger Wyndham
- Rouzbeh Afsari
- Roxane Gaisset
- Rui Barata
- Sadia Jahan
- Saif Al Chalabi
- Salem Almaani
- Salia Virxinia Pol Heres
- Sam Daneshvari
- Samir Parikh
- Sandra Karanovic
- Sang-Kyung Jo
- Sapna Shah
- Sara Fernandes
- Sara Goncalves
- Sara Ombelet
- Sara Vigano
- Sarah Ashley Ford Sightler
- Sarah Lawman
- Sarah Quinn
- Sarah Roxburgh
- Saravanan Balamuthusamy
- Se Joong Kim
- Sebahat Sat
- Secundino Cigarran Guldris
- Selena Longhi
- Serena Ponti
- Seung Hyeok Han
- SeWon Oh
- Shamik Bhadra
- Shang-Feng Tsai
- Shang-Jyh Hwang
- Sharon Adler
- Shaundeep Sen
- Sheng Kuo
- Shih-Hsiang Ou
- Shih-Ping Hsu
- Shilpanjali Jesudason
- Sian Griffin
- Siddhartha Kattamanchi
- Silja Sanden
- Silvia Malvica
- Simon Mucha
- Simon Roger
- Simone Accarino
- Simone Kulka
- Siu Fai Cheung
- Smeeta Sinha
- Sofia Jorge
- Sofie Jamar
- Songuk Yoon
- Sradha Kotwal
- Sreedhar Mandayam
- Stacy Martinez
- Stefan Weiner
- Stefanie Stangenberg
- Stefano Costanzi
- Stephan Christian Werth
- Stephane Burtey
- Stephane Roueff
- Stephen McDonald
- Stewart Bieler BA a
- Sui Kon
- Suneel Udani
- Sunggyun Kim
- Susan Crail
- Susan Wan
- Suzanne Forbes
- Sven Heinrichs
- Sydney Chi Wai Tang
- Syeda Ahmad
- Sze Ho Sunny Wong
- Szu-Yu Pan
- Sónia Silva
- Tae-Hyun Yoo
- Tak Tai Andrew Yue
- Tamara Malek Marin
- Tania Salehi
- Teresa Furtado
- Theodoros Kasimatis
- Thida Maung Maung Myint
- Thilo Krueger
- Thomas Bucknall
- Thomas Malfait
- Thomas Powell
- Thomas Weinreich
- Thu Nguyen
- Tiane Dai
- Toby Coates
- Tomasz Stompor
- Tung-Min Yu
- Tze Goh
- Tzung-Yo Ho
- Ulrich Kunzendorf
- Ulysses Diva PhD f
- Unnikrishnan Pillai
- Unnikrishnan Pillai
- Ursula Verdalles Guzman
- Urte Zakauskiene
- Usha Peri
- Valentin Mayet
- Valérie de Précigout
- Veronica Viramontes
- Victor Fernandez
- Victoria Campbell
- Victoria Campbell
- Vidu Wijeratne
- Viet Nguyen
- Viet Nguyen
- Vittoria Esposito
- Vladmir Tesar
- Wai Lim
- Wai Ping Law
- Wan-Chuan Tsai
- Wanja Bernhardt
- Wenceslao Adrian Aguilera Morales
- William Paxton
- William Rote PhD f
- Wim Lemahieu
- Wladyslaw Sulowicz
- Wooin Ahn
- Wookyung Chung
- Xavier Warling
- Yahsou Delmas
- Yan Li
- Yelena Drexler
- Yen-Ling Chiu
- Yeong Hoon Kim
- Yi-Wen Chiu
- Yick Hei Wong
- Yonatan Peleg
- Young Rim Song
- YoungYoul Hyun
- Yu-Sen Peng
- Yunmi Kim
- Yusuf Eqbal
- Yusuf Eqbal
- Yvonne Shen
- Zivka Dika
- Zoltan Endre
- Zvonimir Sitas
- Publication venue
- Publication date
- 01/01/2023
- Field of study
Background: Sparsentan is a novel, non-immunosuppressive, single-molecule, dual endothelin and angiotensin receptor antagonist being examined in an ongoing phase 3 trial in adults with IgA nephropathy. We report the prespecified interim analysis of the primary proteinuria efficacy endpoint, and safety. Methods: PROTECT is an international, randomised, double-blind, active-controlled study, being conducted in 134 clinical practice sites in 18 countries. The study examines sparsentan versus irbesartan in adults (aged ≥18 years) with biopsy-proven IgA nephropathy and proteinuria of 1·0 g/day or higher despite maximised renin-angiotensin system inhibitor treatment for at least 12 weeks. Participants were randomly assigned in a 1:1 ratio to receive sparsentan 400 mg once daily or irbesartan 300 mg once daily, stratified by estimated glomerular filtration rate at screening (30 to 1·75 g/day). The primary efficacy endpoint was change from baseline to week 36 in urine protein-creatinine ratio based on a 24-h urine sample, assessed using mixed model repeated measures. Treatment-emergent adverse events (TEAEs) were safety endpoints. All endpoints were examined in all participants who received at least one dose of randomised treatment. The study is ongoing and is registered with ClinicalTrials.gov, NCT03762850. Findings: Between Dec 20, 2018, and May 26, 2021, 404 participants were randomly assigned to sparsentan (n=202) or irbesartan (n=202) and received treatment. At week 36, the geometric least squares mean percent change from baseline in urine protein-creatinine ratio was statistically significantly greater in the sparsentan group (-49·8%) than the irbesartan group (-15·1%), resulting in a between-group relative reduction of 41% (least squares mean ratio=0·59; 95% CI 0·51-0·69; p<0·0001). TEAEs with sparsentan were similar to irbesartan. There were no cases of severe oedema, heart failure, hepatotoxicity, or oedema-related discontinuations. Bodyweight changes from baseline were not different between the sparsentan and irbesartan groups. Interpretation: Once-daily treatment with sparsentan produced meaningful reduction in proteinuria compared with irbesartan in adults with IgA nephropathy. Safety of sparsentan was similar to irbesartan. Future analyses after completion of the 2-year double-blind period will show whether these beneficial effects translate into a long-term nephroprotective potential of sparsentan. Funding: Travere Therapeutics
Efficacy and safety of sparsentan versus irbesartan in patients with IgA nephropathy (PROTECT): 2-year results from a randomised, active-controlled, phase 3 trial
- Author
- Aaron Fearday (17386231)
- Abdallah Geara (17386297)
- Adam Morris (2043517)
- Adriana Fernandes (8856416)
- Adriana Sierra Ochoa (17386699)
- Aejin Kim (2175798)
- Agata Winiarska (17387086)
- Aine Maire De Bhailis (17386168)
- Ajay Dhaygude (10682946)
- Alastair Gillies (17386309)
- Alba Atenza (17385991)
- Alberto Ortiz Arduan (17385973)
- Alejandro Soria Villen (17387041)
- Alessia Fornoni (519467)
- Alex Mercer (59669)
- Alexandre Buffet (14930766)
- Alexandre Karras (506611)
- Alfred Rodriguez (17386840)
- Ali Assefi (17385988)
- Allister Williams (17387083)
- Allyson Medina (17386612)
- Alvaro Vaz (17387023)
- Alvita Vickiene (6473255)
- Amanda Hall (210816)
- Amanda Mather (285324)
- Amanda Siriwardana (17386933)
- Amar Mahdi (10295868)
- Amy Henderson (17386369)
- Amy Hudson (8412594)
- An Vanacker (17387017)
- Ana Avila Bernabeu (17386036)
- Ana Carolina Figueiredo (17386246)
- Ana Cortesão Costa (5670833)
- Ana Farinha (17386228)
- Ana Marta Gomes (2851424)
- Ana Messias (17386621)
- Ana Natario (17386672)
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- Rocco Baccaro (17386009)
- Roderick Comunale (17386150)
- Roger Wyndham (17387101)
- Rouzbeh Afsari (17385934)
- Roxane Gaisset (17386282)
- Rui Barata (10873253)
- Sadia Jahan (12758567)
- Saif Al Chalabi (17385952)
- Salem Almaani (17385958)
- Salia Virxinia Pol Heres (17386375)
- Sam Daneshvari (17386162)
- Samir Parikh (5594378)
- Sandra Karanovic (17386441)
- Sang-Kyung Jo (442610)
- Sapna Shah (579169)
- Sara Fernandes (3121533)
- Sara Goncalves (17386336)
- Sara Ombelet (17386708)
- Sara Vigano (17387029)
- Sarah Ashley (14954712)
- Sarah Lawman (9758498)
- Sarah Quinn (17094908)
- Sarah Roxburgh (17386852)
- Saravanan Balamuthusamy (467385)
- Se Joong Kim (13205663)
- Se Won Oh (9338439)
- Sebahat Sat (17386885)
- Secundino Cigarran Guldris (17386354)
- Selena Longhi (412597)
- Serena Ponti (17386795)
- Seung Hyeok Han (8976257)
- SeWon Oh (17386702)
- Shamik Bhadra (17386039)
- Shang-Feng Tsai (8251905)
- Shang-Jyh Hwang (5312)
- Sharon Adler (3404507)
- Shaundeep Sen (121125)
- Sheng Kuo (17386492)
- Shih-Hsiang Ou (2832815)
- Shih-Ping Hsu (315722)
- Shilpanjali Jesudason (17386417)
- Sian Griffin (8401269)
- Siddhartha Kattamanchi (15358922)
- Silja Sanden (17386867)
- Silvia Malvica (17386573)
- Simon Mucha (6437372)
- Simon Roger (3661408)
- Simone Accarino (17385928)
- Simone Kulka (17386489)
- Siu Fai Cheung (17386114)
- Smeeta Sinha (4847929)
- Sofia Jorge (12731115)
- Sofie Jamar (5331284)
- Songuk Yoon (17387113)
- Sradha Kotwal (6759695)
- Sreedhar Mandayam (9623752)
- Stacy Martinez (8620377)
- Stefan Weiner (17387068)
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- Sui Kon (17386477)
- Suneel Udani (17387005)
- Sunggyun Kim (17386459)
- Susan Crail (6164591)
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- Thu Nguyen (2179258)
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- Tomasz Stompor (3433691)
- Tung-Min Yu (546163)
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- Ulrich Kunzendorf (5780207)
- Ulysses A Diva (17385901)
- Unnikrishnan Pillai (17386783)
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- Valérie de Précigout (17386171)
- Veronica Viramontes (17387044)
- Victor Fernandez (17386243)
- Victoria Campbell (239881)
- Vidu Wijeratne (17387077)
- Viet Nguyen (79713)
- Vittoria Esposito (5787344)
- Vladimir Tesar (156920)
- Vlado Perkovic (141532)
- Wai Lim (3583598)
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- Yi-Wen Chiu (106535)
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- Yonatan Peleg (9922071)
- Young Rim Song (13242926)
- Young Youl Hyun (13016397)
- Yu-Sen Peng (315725)
- Yunmi Kim (3040866)
- Yusuf Eqbal (17386222)
- Yvonne Shen (17386921)
- Zivka Dika (10281479)
- Zoltan Endre (714028)
- Zvonimir Sitas (17386936)
- Publication venue
- Publication date
- 01/12/2023
- Field of study
Background
Sparsentan, a novel, non-immunosuppressive, single-molecule, dual endothelin angiotensin receptor antagonist, significantly reduced proteinuria versus irbesartan, an angiotensin II receptor blocker, at 36 weeks (primary endpoint) in patients with immunoglobulin A nephropathy in the phase 3 PROTECT trial's previously reported interim analysis. Here, we report kidney function and outcomes over 110 weeks from the double-blind final analysis.
Methods
PROTECT, a double-blind, randomised, active-controlled, phase 3 study, was done across 134 clinical practice sites in 18 countries throughout the Americas, Asia, and Europe. Patients aged 18 years or older with biopsy-proven primary IgA nephropathy and proteinuria of at least 1·0 g per day despite maximised renin–angiotensin system inhibition for at least 12 weeks were randomly assigned (1:1) to receive sparsentan (target dose 400 mg oral sparsentan once daily) or irbesartan (target dose 300 mg oral irbesartan once daily) based on a permuted-block randomisation method. The primary endpoint was proteinuria change between treatment groups at 36 weeks. Secondary endpoints included rate of change (slope) of the estimated glomerular filtration rate (eGFR), changes in proteinuria, a composite of kidney failure (confirmed 40% eGFR reduction, end-stage kidney disease, or all-cause mortality), and safety and tolerability up to 110 weeks from randomisation. Secondary efficacy outcomes were assessed in the full analysis set and safety was assessed in the safety set, both of which were defined as all patients who were randomly assigned and received at least one dose of randomly assigned study drug. This trial is registered with ClinicalTrials.gov, NCT03762850.
Findings
Between Dec 20, 2018, and May 26, 2021, 203 patients were randomly assigned to the sparsentan group and 203 to the irbesartan group. One patient from each group did not receive the study drug and was excluded from the efficacy and safety analyses (282 [70%] of 404 included patients were male and 272 [67%] were White) . Patients in the sparsentan group had a slower rate of eGFR decline than those in the irbesartan group. eGFR chronic 2-year slope (weeks 6–110) was −2·7 mL/min per 1·73 m2 per year versus −3·8 mL/min per 1·73 m2 per year (difference 1·1 mL/min per 1·73 m2 per year, 95% CI 0·1 to 2·1; p=0·037); total 2-year slope (day 1–week 110) was −2·9 mL/min per 1·73 m2 per year versus −3·9 mL/min per 1·73 m2 per year (difference 1·0 mL/min per 1·73 m2 per year, 95% CI −0·03 to 1·94; p=0·058). The significant reduction in proteinuria at 36 weeks with sparsentan was maintained throughout the study period; at 110 weeks, proteinuria, as determined by the change from baseline in urine protein-to-creatinine ratio, was 40% lower in the sparsentan group than in the irbesartan group (−42·8%, 95% CI −49·8 to −35·0, with sparsentan versus −4·4%, −15·8 to 8·7, with irbesartan; geometric least-squares mean ratio 0·60, 95% CI 0·50 to 0·72). The composite kidney failure endpoint was reached by 18 (9%) of 202 patients in the sparsentan group versus 26 (13%) of 202 patients in the irbesartan group (relative risk 0·7, 95% CI 0·4 to 1·2). Treatment-emergent adverse events were well balanced between sparsentan and irbesartan, with no new safety signals.
Interpretation
Over 110 weeks, treatment with sparsentan versus maximally titrated irbesartan in patients with IgA nephropathy resulted in significant reductions in proteinuria and preservation of kidney function.</p
Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356
- Author
- Abdelmohsen Kotb
- Abe Akihisa
- Abedin Md Joynal
- Abeliovich Hagai
- Adachi Hiroaki
- Adams Christopher M.
- Adams Peter D.
- Adeli Khosrow
- Adhihetty Peter J.
- Adler Sharon G.
- Agam Galila
- Agarwal Rajesh
- Aghi Manish K.
- Agnello Maria
- Agostinis Patrizia
- Aguilar Patricia V.
- Aguirre-Ghiso Julio
- Airoldi Edoardo M.
- Ait-Si-Ali Slimane
- Akematsu Takahiko
- Akporiaye Emmanuel T.
- Al-Rubeai Mohamed
- Albaiceta Guillermo M.
- Albanese Chris
- Albani Diego
- Albert Matthew L.
- Aldudo Jesus
- Algül Hana
- Alirezaei Mehrdad
- Alloza Iraide
- Almasan Alexandru
- Almonte-Beceril Maylin
- Alnemri Emad S.
- Alonso Covadonga
- Altan-Bonnet Nihal
- Altieri Dario C.
- Alvarez Silvia
- Alvarez-Erviti Lydia
- Alves Sandro
- Amadoro Giuseppina
- Amano Atsuo
- Amantini Consuelo
- Ambrosio Santiago
- Amelio Ivano
- Amer Amal O.
- Amessou Mohamed
- Amon Angelika
- An Zhenyi
- Anania Frank A.
- Andersen Stig U.
- Andley Usha P.
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- Andrieu-Abadie Nathalie
- Anel Alberto
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- Aquila Saveria
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- Aranda Agustin
- Araya Jun
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- Wang Mei
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- Wang Yipeng
- Wang Yu
- Wang Yu Tian
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- Wang Zhi-Nong
- Wappner Pablo
- Ward Carl
- Ward Diane McVey
- Warnes Gary
- Watada Hirotaka
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- Watase Kei
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- Weekes Colin D.
- Wei Jiwu
- Weide Thomas
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- Weis Simone Nardin
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- Westermann Benedikt
- Weyand Cornelia M.
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- Wild Franziska
- Wildenberg Manon E.
- Wileman Tom
- Wilkinson Deepti Srinivas
- Wilkinson Simon
- Willbold Dieter
- Williams Chris
- Williams Katherine
- Williamson Peter R.
- Winklhofer Konstanze F.
- Witkin Steven S.
- Wohlgemuth Stephanie E.
- Wollert Thomas
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- Xilouri Maria
- Xiong Yuyan
- Xu Chuanshan
- Xu Congfeng
- Xu Feng
- Xu Haoxing
- Xu Hongwei
- Xu Jian
- Xu Jianzhen
- Xu Jinxian
- Xu Liang
- Xu Xiaolei
- Xu Yangqing
- Xu Ye
- Xu Zhi-Xiang
- Xu Ziheng
- Xue Yu
- Yamada Takahiro
- Yamamoto Ai
- Yamanaka Koji
- Yamashina Shunhei
- Yamashiro Shigeko
- Yan Bing
- Yan Bo
- Yan Xianghua
- Yan Zhen
- Yanagi Yasuo
- Yang Dun-Sheng
- Yang Jin-Ming
- Yang Liu
- Yang Minghua
- Yang Pei-Ming
- Yang Peixin
- Yang Qian
- Yang Wannian
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- Yang Xuesong
- Yang Yi
- Yang Ying
- Yang Zhifen
- Yang Zhihong
- Yao Meng-Chao
- Yao Pamela J.
- Yao Xiaofeng
- Yao Zhenyu
- Yao Zhiyuan
- Yasui Linda S.
- Ye Mingxiang
- Yedvobnick Barry
- Yeganeh Behzad
- Yeh Elizabeth S.
- Yeyati Patricia L.
- Yi Fan
- Yi Long
- Yin Xiao-Ming
- Yip Calvin K.
- Yoo Yeong-Min
- Yoo Young Hyun
- Yoon Seung-Yong
- Yoshida Ken-Ichi
- Yoshimori Tamotsu
- Young Ken H.
- Yu Huixin
- Yu Jane J.
- Yu Jin-Tai
- Yu Jun
- Yu Li
- Yu W. Haung
- Yu Xiao-Fang
- Yu Zhengping
- Yuan Junying
- Yuan Zhi-Min
- Yue Beatrice Y. J. T.
- Yue Jianbo
- Yue Zhenyu
- Zacks David N.
- Zacksenhaus Eldad
- Zaffaroni Nadia
- Zaglia Tania
- Zakeri Zahra
- Zecchini Vincent
- Zeng Jinsheng
- Zeng Min
- Zeng Qi
- Zervos Antonis S.
- Zhang Donna D.
- Zhang Fan
- Zhang Guo
- Zhang Guo-Chang
- Zhang Hao
- Zhang Hong
- Zhang Hongbing
- Zhang Jian
- Zhang Jiangwei
- Zhang Jianhua
- Zhang Jing-Pu
- Zhang Li
- Zhang Lin
- Zhang Long
- Zhang Ming-Yong
- Zhang Xiangnan
- Zhang Xu Dong
- Zhang Yan
- Zhang Yang
- Zhang Yanjin
- Zhang Yingmei
- Zhang Yunjiao
- Zhao Mei
- Zhao Wei-Li
- Zhao Xiaonan
- Zhao Yan G.
- Zhao Ying
- Zhao Yongchao
- Zhao Yu-Xia
- Zhao Zhendong
- Zhao Zhizhuang J.
- Zheng Dexian
- Zheng Xi-Long
- Zheng Xiaoxiang
- Zhivotovsky Boris
- Zhong Qing
- Zhou Guang-Zhou
- Zhou Guofei
- Zhou Huiping
- Zhou Shu-Feng
- Zhou Xu-Jie
- Zhu Hongxin
- Zhu Hua
- Zhu Wei-Guo
- Zhu Wenhua
- Zhu Xiao-Feng
- Zhu Yuhua
- Zhuang Shi-Mei
- Zhuang Xiaohong
- Ziparo Elio
- Zois Christos E.
- Zoladek Teresa
- Zong Wei-Xing
- Zorzano Antonio
- Zughaier Susu M.
- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2016
- Field of study
non present
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
- Author
- Abdelmohsen Kotb
- Abe Akihisa
- Abedin Md Joynal
- Abeliovich Hagai
- Adachi Hiroaki
- Adams Christopher M.
- Adams Peter D.
- Adeli Khosrow
- Adhihetty Peter J.
- Adler Sharon G.
- Agam Galila
- Agarwal Rajesh
- Aghi Manish K.
- Agnello Maria
- Agostinis Patrizia
- Aguilar Patricia V.
- Aguirre-Ghiso Julio
- Airoldi Edoardo M.
- Ait-Si-Ali Slimane
- Akematsu Takahiko
- Akporiaye Emmanuel T.
- Al-Rubeai Mohamed
- Albaiceta Guillermo M.
- Albanese Chris
- Albani Diego
- Albert Matthew L.
- Aldudo Jesus
- Alguel Hana
- Alirezaei Mehrdad
- Alloza Iraide
- Almasan Alexandru
- Almonte-Beceril Maylin
- Alnemri Emad S.
- Alonso Covadonga
- Altan-Bonnet Nihal
- Altieri Dario C.
- Alvarez Silvia
- Alvarez-Erviti Lydia
- Alves Sandro
- Amadoro Giuseppina
- Amano Atsuo
- Amantini Consuelo
- Ambrosio Santiago
- Amelio Ivano
- Amer Amal O.
- Amessou Mohamed
- Amon Angelika
- An Zhenyi
- Ana Gonzalez-Polo Rosa
- Anania Frank A.
- Andersen Stig U.
- Andley Usha P.
- Andreadi Catherine K.
- Andrieu-Abadie Nathalie
- Anel Alberto
- Ann David K.
- Anoopkumar-Dukie Shailendra
- Antonioli Manuela
- Aoki Hiroshi
- Apostolova Nadezda
- Aquila Saveria
- Aquilano Katia
- Araki Koichi
- Arama Eli
- Aranda Agustin
- Araya Jun
- Arcaro Alexandre
- Arias Esperanza
- Arimoto Hirokazu
- Ariosa Aileen R.
- Armstrong Jane L.
- Arnould Thierry
- Arozena Abraham Acevedo
- Arsov Ivica
- Asanuma Katsuhiko
- Askanas Valerie
- Asselin Eric
- Atarashi Ryuichiro
- Atherton Sally S.
- Atkin Julie D.
- Attardi Laura D.
- Auberger Patrick
- Auburger Georg
- Aurelian Laure
- Autelli Riccardo
- Avagliano Laura
- Avantaggiati Maria Laura
- Avrahami Limor
- Awale Suresh
- Azad Neelam
- Bachetti Tiziana
- Backer Jonathan M.
- Bae Dong-Hun
- Bae Jae-Sung
- Bae Ok-Nam
- Bae Soo Han
- Baehrecke Eric H.
- Baek Seung-Hoon
- Baghdiguian Stephen
- Bagniewska-Zadworna Agnieszka
- Bai Hua
- Bai Jie
- Bai Xue-Yuan
- Bailly Yannick
- Balaji Kithiganahalli Narayanaswamy
- Balduini Walter
- Ballabio Andrea
- Balzan Rena
- Banerjee Rajkumar
- Banhegyi Gabor
- Bao Haijun
- Barbato Daniele Lettieri
- Barbeau Benoit
- Barrachina Maria D.
- Barreiro Esther
- Bartel Bonnie
- Bartolome Alberto
- Bassham Diane C.
- Bassi Maria Teresa
- Bast Robert C., Jr.
- Basu Alakananda
- Batista Maria Teresa
- Batoko Henri
- Battino Maurizio
- Bauckman Kyle
- Baumgarner Bradley L.
- Bayer K. Ulrich
- Beale Rupert
- Beaulieu Jean-Francois
- Beck George R., Jr.
- Becker Christoph
- Beckham J. David
- Bedard Pierre-Andre
- Bednarski Patrick J.
- Begley Thomas J.
- Behl Christian
- Behrends Christian
- Behrens Georg M. N.
- Behrns Kevin E.
- Bejarano Eloy
- Belaid Amine
- Belleudi Francesca
- Benard Giovanni
- Berchem Guy
- Bergamaschi Daniele
- Bergami Matteo
- Berkhout Ben
- Berliocchi Laura
- Bernard Amelie
- Bernard Monique
- Bernassola Francesca
- Bertolotti Anne
- Bess Amanda S.
- Besteiro Sebastien
- Bettuzzi Saverio
- Bhalla Savita
- Bhattacharyya Shalmoli
- Bhutia Sujit K.
- Biagosch Caroline
- Bianchi Michele Wolfe
- Biard-Piechaczyk Martine
- Billes Viktor
- Bincoletto Claudia
- Bingol Baris
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- Wen Xin
- Wen Yunfei
- Westermann Benedikt
- Weyand Cornelia M.
- White Anthony R.
- White Eileen
- Whitton J. Lindsay
- Whitworth Alexander J.
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- Wild Franziska
- Wildenberg Manon E.
- Wileman Tom
- Wilkinson Deepti Srinivas
- Wilkinson Simon
- Willbold Dieter
- Williams Chris
- Williams Katherine
- Williamson Peter R.
- Winklhofer Konstanze F.
- Witkin Steven S.
- Wohlgemuth Stephanie E.
- Wollert Thomas
- Wolvetang Ernst J.
- Wong Esther
- Wong G. William
- Wong Richard W.
- Wong Vincent Kam Wai
- Woodcock Elizabeth A.
- Wright Karen L.
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- Wu Defeng
- Wu Gen Sheng
- Wu Jian
- Wu Junfang
- Wu Mian
- Wu Min
- Wu Shengzhou
- Wu William K. K.
- Wu Yaohua
- Wu Zhenlong
- Xavier Cristina P. R.
- Xavier Ramnik J.
- Xia Gui-Xian
- Xia Tian
- Xia Weiliang
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- Xiao Jian
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- Xiao Wuhan
- Xie Chuan-Ming
- Xie Zhiping
- Xie Zhonglin
- Xilouri Maria
- Xiong Yuyan
- Xu Chuanshan
- Xu Congfeng
- Xu Feng
- Xu Haoxing
- Xu Hongwei
- Xu Jian
- Xu Jianzhen
- Xu Jinxian
- Xu Liang
- Xu Xiaolei
- Xu Yangqing
- Xu Ye
- Xu Zhi-Xiang
- Xu Ziheng
- Xue Yu
- Yamada Takahiro
- Yamamoto Ai
- Yamanaka Koji
- Yamashina Shunhei
- Yamashiro Shigeko
- Yan Bing
- Yan Bo
- Yan Xianghua
- Yan Zhen
- Yanagi Yasuo
- Yang Dun-Sheng
- Yang Jin-Ming
- Yang Liu
- Yang Minghua
- Yang Pei-Ming
- Yang Peixin
- Yang Qian
- Yang Wannian
- Yang Wei Yuan
- Yang Xuesong
- Yang Yi
- Yang Ying
- Yang Zhifen
- Yang Zhihong
- Yao Meng-Chao
- Yao Pamela J.
- Yao Xiaofeng
- Yao Zhenyu
- Yao Zhiyuan
- Yasui Linda S.
- Ye Mingxiang
- Yedvobnick Barry
- Yeganeh Behzad
- Yeh Elizabeth S.
- Yeyati Patricia L.
- Yi Fan
- Yi Long
- Yin Xiao-Ming
- Yip Calvin K.
- Yoo Yeong-Min
- Yoo Young Hyun
- Yoon Seung-Yong
- Yoshida Ken-Ichi
- Yoshimori Tamotsu
- Young Ken H.
- Yu Huixin
- Yu Jane J.
- Yu Jin-Tai
- Yu Jun
- Yu Li
- Yu W. Haung
- Yu Xiao-Fang
- Yu Zhengping
- Yuan Junying
- Yuan Zhi-Min
- Yue Beatrice Y. J. T.
- Yue Jianbo
- Yue Zhenyu
- Zacks David N.
- Zacksenhaus Eldad
- Zaffaroni Nadia
- Zaglia Tania
- Zakeri Zahra
- Zecchini Vincent
- Zeng Jinsheng
- Zeng Min
- Zeng Qi
- Zervos Antonis S.
- Zhang Donna D.
- Zhang Fan
- Zhang Guo
- Zhang Guo-Chang
- Zhang Hao
- Zhang Hong
- Zhang Hong
- Zhang Hongbing
- Zhang Jian
- Zhang Jian
- Zhang Jiangwei
- Zhang Jianhua
- Zhang Jing-pu
- Zhang Li
- Zhang Lin
- Zhang Lin
- Zhang Long
- Zhang Ming-Yong
- Zhang Xiangnan
- Zhang Xu Dong
- Zhang Yan
- Zhang Yang
- Zhang Yanjin
- Zhang Yingmei
- Zhang Yunjiao
- Zhao Mei
- Zhao Wei-Li
- Zhao Xiaonan
- Zhao Yan G.
- Zhao Ying
- Zhao Yongchao
- Zhao Yu-Xia
- Zhao Zhendong
- Zhao Zhizhuang J.
- Zheng Dexian
- Zheng Xi-Long
- Zheng Xiaoxiang
- Zhivotovsky Boris
- Zhong Qing
- Zhou Guang-Zhou
- Zhou Guofei
- Zhou Huiping
- Zhou Shu-Feng
- Zhou Xu-Jie
- Zhu Hongxin
- Zhu Hua
- Zhu Wei-Guo
- Zhu Wenhua
- Zhu Xiao-Feng
- Zhu Yuhua
- Zhuang Shi-Mei
- Zhuang Xiaohong
- Ziparo Elio
- Zois Christos E.
- Zoladek Teresa
- Zong Wei-Xing
- Zorzano Antonio
- Zughaier Susu M.
- Publication venue
- Publication date
- 01/01/2016
- Field of study
Search for physics beyond the standard model in top quark production with additional leptons in the context of effective field theory
- Author
- Aarrestad Thea Klaeboe
- Aarup Petersen Henriette
- Abbaneo Duccio
- Abbott Mark Samuel
- Abbrescia Marcello
- Abdullin Salavat
- Abreu Andrés
- Abu Zeid Shimaa
- Acharya Himal
- Acosta Darin
- Adam Wolfgang
- Adamidis Kosmas
- Adams Eric
- Adams Mark Raymond
- Adams Todd
- Addesa Francesca Maria
- Adloff Catherine
- Adzic Petar
- Aebi Devin
- Afanasiev Serguei
- Agapitos Antonis
- Agarwal Garvita
- Agram Jean-Laurent
- Aguilar-Benitez Manuel
- Agyel Doruk
- Ahmad Ashfaq
- Ahmad Muhammad
- Ahmed Asar
- Aimè Chiara
- Ajmal Sehar
- Akchurin Nural
- Akgun Bora
- Akpinar Alp
- Al Kadhim Ali
- Albert Andreas
- Albrecht Anna
- Albrecht Steffen
- Albrow Michael
- Alcaraz Maestre Juan
- Alcerro Alcerro Luis Fernando
- Aldaya Martin Maria
- Aldá Júnior Walter Luiz
- Aleksandrov Aleksandar
- Alexander James
- Alhusseini Mohammad
- Alimena Juliette
- Alison John
- Allmond Braden
- Ally Daniel
- Almond John
- Alpana Alpana
- Alsufyani Bandar
- Alvarez Gonzalez Barbara
- Alverson George
- Alves Gallo Pereira Miguel
- Alves Gilvan
- Aly Reham
- Alyari Maral
- Amapane Nicola
- Ambrozas Marijus
- Ameen Mohammad Mobassir
- Amendola Chiara
- Amoroso Simone
- Amram Oz
- Amsler Claude
- An Sitong
- An Ying
- Anagnostou Georgios
- Andrea Jeremy
- Andreev Vladimir
- Andreev Yuri
- Andrejkovic Janik Walter
- Andrews Michael Benjamin
- Androsov Konstantin
- Anguiano Justin
- Antchev Georgy
- Anthony David
- Antonello Massimiliano
- Apollinari Giorgio
- Apparu Dylan
- Appelt Eric
- Apresyan Artur
- Araujo Mariana
- Aravind Anagha
- Arcaro Daniel
- Arcidiacono Roberta
- Ardino Rocco
- Argiro Stefano
- Arneodo Michele
- Aruta Caterina
- Asawatangtrakuldee Chayanit
- Asenov Patrick
- Asghar Muhammad Irfan
- Asilar Ece
- Askew Andrew
- Assiouras Panagiotis
- Atakisi Ismail Okan
- Attikis Alexandros
- Auffray Etiennette
- Aushev Tagir
- Auzinger Georg
- Avati Valentina
- Avery Paul
- Avila Carlos
- Awais Ali
- Awan Muhammad Imran Malik
- Ayala Edy
- Ayala Gabriel
- Aydilek Orhan
- Azarkin Maksim
- Aziz Tariq
- Azzi Patrizia
- Azzurri Paolo
- Baarmand Marc M
- Babaev Anton
- Babbar Jyoti
- Bacchetta Nicola
- Bachtis Michail
- Backhaus Malte
- Baden Drew
- Baechler Joachim
- Bagliesi Giuseppe
- Bahinipati Seema
- Bainbridge Robert
- Bak Gyeonghwan
- Bakas Georgios
- Bakhshiansohi Hamed
- Bakshi Amandeep Singh
- Bala Anirban
- Baldenegro Barrera Cristian
- Ball Austin
- Ban Yong
- Band Reyer
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- Banerjee Sudeshna
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- Barman Soumyadip
- Barnes Virgil E
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- Behnke Olaf
- Bein Samuel
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- Belforte Stefano
- Bell Ken W
- Bellan Riccardo
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- Christoforou Konstantinos
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- de Barbaro Pawel
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- de Iorio Agostino
- de Jesus Damiao Dilson
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- de Lentdecker Gilles
- de Leo Ksenia
- de Moor Alexandre
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- Yao Yao
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- Yates Brent
- Yazgan Efe
- Ye Zhenyu
- Yi Kai
- Yi Ruole
- Yigitbasi Efe
- Yockey Henry
- Yohay Rachel
- Yoo Hwi Dong
- Yoo Jaehyeok
- Yoo Jieun
- Yoon Inseok
- You Zhengyun
- Yu David
- Yu Intae
- Yu Shin-Shan
- Yuan Li
- Yuan Siqi
- Yuldashev Bekhzod S
- Yumiceva Francisco
- Yusuff Imran
- Zabi Alexandre
- Zacharopoulou Anna
- Zaleski Shawn
- Zalewski Piotr
- Zanetti Marco
- Zarubin Anatoli
- Zarucki Mateusz
- Zaza Angela
- Zecchinelli Angelo Giacomo
- Zehetner Philipp
- Zeinali Maryam
- Zejdl Petr
- Zeuner Wolfram Dietrich
- Zghiche Amina
- Zhang Fengwangdong
- Zhang Huaqiao
- Zhang Jingyu
- Zhang Wenyu
- Zhang Yousen
- Zhang Yu
- Zhizhin Ilia
- Zhokin Alexander
- Zhou Chen
- Zhu Ren-Yuan
- Ziemons Tim
- Zilizi Gyula
- Zimermmane Castro Santos André
- Zipper Noah
- Zisopoulos Ilias
- Zoi Irene
- Zolkapli Zukhaimira
- Zorbakir Ibrahim Soner
- Zorbilmez Caglar
- Zotto Pierluigi
- Zotz Alexander
- Zou Rui
- Zucchetta Alberto
- Zuo Xunwu
- Zuolo Davide
- Zygala Lara
- Publication venue
- HAL CCSD
- Publication date
- 12/10/2023
- Field of study
International audienceA search for new physics in top quark production with additional final-state leptons is performed using data collected by the CMS experiment in proton-proton collisions at s = 13 TeV at the LHC during 2016-2018. The data set corresponds to an integrated luminosity of 138 fb−1. Using the framework of effective field theory (EFT), potential new physics effects are parametrized in terms of 26 dimension-six EFT operators. The impacts of EFT operators are incorporated through the event-level reweighting of Monte Carlo simulations, which allows for detector-level predictions. The events are divided into several categories based on lepton multiplicity, total lepton charge, jet multiplicity, and b-tagged jet multiplicity. Kinematic variables corresponding to the transverse momentum (pT) of the leading pair of leptons and/or jets as well as the pT of on-shell Z bosons are used to extract the 95% confidence intervals of the 26 Wilson coefficients corresponding to these EFT operators. No significant deviation with respect to the standard model prediction is found
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