Two Disputes of Methods Three Constructivisms and Three Liberalisms. Part I

The paper proposes to reconsider the methodology and history of economics radically, whether present day mainstream or heterodox versions of it. The profession of economists must definitely abandon Cartesian dualism and adopt Vygotskian constructivism. In fact constructivist economics already existed in the past and was cognitively very successful and socially very useful. It was the economics of Gustav Schmoller’s historico-ethical school and the institutionalist economics of John R. Commons, traditions of which are totally ignored by the contemporary community of economists. The former tradition was based on Dilthey’s hermeneutics and the latter on Peirce’s pragmatism. It is worth to underline that hermeneutics and pragmatism are both predecessors of Vygotskian constructivism. During the last two decades a lot was written by economists on pragmatist, constructivist and discursive approaches to the methodology and history of economics, but those who wrote on these topics viewed them from the dualistic point of view. My paper is an appeal to economists to reconsider Methodenstreit. The dispute of methods between Schmoller and Menger can be considered as a repetition of a similar dispute taking place more than two hundred years earlier between Robert Boyle and Thomas Hobbes. Schmoller-Menger dispute started soon after the beginning of the institutionalisation of experimentally-oriented economics which happened with the creation in 1873 of the Vereinf?r Sozialpolitik. Boyle-Hobbes dispute started in 1660, when the Royal Society of London had been founded, the cradle of the institution of science. Schmoller was one of the creators of the Verein, and Boyle was one of the founders of the Royal Society. The activities of both societies were similar in several respects: they represented efforts to collect data, working out of detailed reports and collective evaluation of obtained results. For Hobbes, as for Menger, the model of ‘science’ was geometry. Boyle and Schmoller privileged collecting and analysing data. Boyle did win the dispute, Schmoller did loose. It happened because of different attitudes of powerful groups in societies towards natural scientific experimental research and experimental social research. They were interested in the former, and they saw much more danger than benefit for them in the latter. On the contrary, they were interested in abstract theoretical constructions justifying the market vision of society and laissez-faire. This kind of constructions corresponded to deeply enrooted scholastic traditions of European universities to teach theology and linked with it philosophy. In the framework of these traditions, mathematics was considered as a summit of the scientific approach. On the one hand, the adoption of constructivism by economists would turn their discipline into a science functionally close to natural sciences. On the other hand the Vygotskian constructivism, as a social and political philosophy, once accepted by economists, may lead them to become preachers of the communitarian liberalism with its emphasis on social responsibility, deliberative democracy, and discourse ethics

Two disputes of methods, three constructivisms, and three liberalisms

The paper proposes to reconsider the methodology and history of economics radically, whether present day mainstream or heterodox versions of it. The profession of economists must definitely abandon Cartesian dualism and adopt Vygotskian constructivism. In fact constructivist economics already existed in the past and was cognitively very successful and socially very useful. It was the economics of Gustav Schmoller's historico-ethical school and the institutionalist economics of John R. Commons, traditions of which are totally ignored by the contemporary community of economists. The former tradition was based on Dilthey's hermeneutics and the latter on Peirce's pragmatism. It is worth to underline that hermeneutics and pragmatism are both predecessors of Vygotskian constructivism. During the last two decades a lot was written by economists on pragmatist, constructivist and discursive approaches to the methodology and history of economics, but those who wrote on these topics viewed them from the dualistic point of view. My paper is an appeal to economists to reconsider Methodenstreit. The dispute of methods between Schmoller and Menger can be considered as a repetition of a similar dispute taking place more than two hundred years earlier between Robert Boyle and Thomas Hobbes. Schmoller-Menger dispute started soon after the beginning of the institutionalisation of experimentally-oriented economics which happened with the creation in 1873 of the Vereinfür Sozialpolitik. Boyle-Hobbes dispute started in 1660, when the Royal Society of London had been founded, the cradle of the institution of science. Schmoller was one of the creators of the Verein, and Boyle was one of the founders of the Royal Society. The activities of both societies were similar in several respects: they represented efforts to collect data, working out of detailed reports and collective evaluation of obtained results. For Hobbes, as for Menger, the model of 'science' was geometry. Boyle and Schmoller privileged collecting and analysing data. Boyle did win the dispute, Schmoller did loose. It happened because of different attitudes of powerful groups in societies towards natural scientific experimental research and experimental social research. They were interested in the former, and they saw much more danger than benefit for them in the latter. On the contrary, they were interested in abstract theoretical constructions justifying the market vision of society and laissez-faire. This kind of constructions corresponded to deeply enrooted scholastic traditions of European universities to teach theology and linked with it philosophy. In the framework of these traditions, mathematics was considered as a summit of the scientific approach. On the one hand, the adoption of constructivism by economists would turn their discipline into a science functionally close to natural sciences. On the other hand the Vygotskian constructivism, as a social and political philosophy, once accepted by economists, may lead them to become preachers of the communitarian liberalism with its emphasis on social responsibility, deliberative democracy, and discourse ethics. © 2015 The Journal of Economic Theory

Two disputes of methods, three constructivisms, and three liberalisms

The paper proposes to reconsider the methodology and history of economics radically, whether present day mainstream or heterodox versions of it. The profession of economists must definitely abandon Cartesian dualism and adopt Vygotskian constructivism. In fact constructivist economics already existed in the past and was cognitively very successful and socially very useful. It was the economics of Gustav Schmoller's historico-ethical school and the institutionalist economics of John R. Commons, traditions of which are totally ignored by the contemporary community of economists. The former tradition was based on Dilthey's hermeneutics and the latter on Peirce's pragmatism. It is worth to underline that hermeneutics and pragmatism are both predecessors of Vygotskian constructivism. During the last two decades a lot was written by economists on pragmatist, constructivist and discursive approaches to the methodology and history of economics, but those who wrote on these topics viewed them from the dualistic point of view. My paper is an appeal to economists to reconsider Methodenstreit. The dispute of methods between Schmoller and Menger can be considered as a repetition of a similar dispute taking place more than two hundred years earlier between Robert Boyle and Thomas Hobbes. Schmoller-Menger dispute started soon after the beginning of the institutionalisation of experimentally-oriented economics which happened with the creation in 1873 of the Vereinfür Sozialpolitik. Boyle-Hobbes dispute started in 1660, when the Royal Society of London had been founded, the cradle of the institution of science. Schmoller was one of the creators of the Verein, and Boyle was one of the founders of the Royal Society. The activities of both societies were similar in several respects: they represented efforts to collect data, working out of detailed reports and collective evaluation of obtained results. For Hobbes, as for Menger, the model of 'science' was geometry. Boyle and Schmoller privileged collecting and analysing data. Boyle did win the dispute, Schmoller did loose. It happened because of different attitudes of powerful groups in societies towards natural scientific experimental research and experimental social research. They were interested in the former, and they saw much more danger than benefit for them in the latter. On the contrary, they were interested in abstract theoretical constructions justifying the market vision of society and laissez-faire. This kind of constructions corresponded to deeply enrooted scholastic traditions of European universities to teach theology and linked with it philosophy. In the framework of these traditions, mathematics was considered as a summit of the scientific approach. On the one hand, the adoption of constructivism by economists would turn their discipline into a science functionally close to natural sciences. On the other hand the Vygotskian constructivism, as a social and political philosophy, once accepted by economists, may lead them to become preachers of the communitarian liberalism with its emphasis on social responsibility, deliberative democracy, and discourse ethics. © 2015 The Journal of Economic Theory

EPIDEMIOLOGICAL CHARACTERISTICS of OUTBREAKS of ACUTE INTESTINAL INFECTIONS IN BASHKORTOSTAN IN 2007-2011

The article presents data about epidemiological characteristics of outbreaks of acute intestinal infections in Bashkortostan for the five-year period, which were obtained in the course of analysis of annual reporting forms # 23 "Information of outbreaks of infectious diseases". Last few years the increasing number of outbreaks of acute intestinal infections and growing quantity of afflicted population are discovered, which is distinctly manifested in outbreaks, registered in organized groups of children and accompanied by steady spreading of pathogens spectrum (with prevalence of Salmonella), mainly transmitted (in 60-100 %) by food. The article also brings up the issue of the necessity of taking into account the identified characteristics of formation and manifestation of outbreaks of acute intestinal infections during the implementation of the system of epidemiological surveillance at regional and municipal levels, with optimization of all its components

Vibrational Spectra of a Mechanosensitive Channel

We report the simulated vibrational spectra of a mechanosensitive membrane channel in different gating states. Our results show that while linear absorption is insensitive to structural differences, linear dichroism and sum-frequency generation spectroscopies are sensitive to the orientation of the transmembrane helices, which is changing during the opening process. Linear dichroism cannot distinguish an intermediate structure from the closed structure, but sum-frequency generation can. In addition, we find that two-dimensional infrared spectroscopy can be used to distinguish all three investigated gating states of the mechanosensitive membrane channel.

PIP2-Binding Site in Kir Channels: Definition by Multiscale Biomolecular Simulations†

Phosphatidylinositol bisphosphate (PIP(2)) is an activator of mammalian inwardly rectifying potassium (Kir) channels. Multiscale simulations, via a sequential combination of coarse-grained and atomistic molecular dynamics, enabled exploration of the interactions of PIP(2) molecules within the inner leaflet of a lipid bilayer membrane with possible binding sites on Kir channels. Three Kir channel structures were investigated: X-ray structures of KirBac1.1 and of a Kir3.1-KirBac1.3 chimera and a homology model of Kir6.2. Coarse-grained simulations of the Kir channels in PIP(2)-containing lipid bilayers identified the PIP(2)-binding site on each channel. These models of the PIP(2)-channel complexes were refined by conversion to an atomistic representation followed by molecular dynamics simulation in a lipid bilayer. All three channels were revealed to contain a conserved binding site at the N-terminal end of the slide (M0) helix, at the interface between adjacent subunits of the channel. This binding site agrees with mutagenesis data and is in the proximity of the site occupied by a detergent molecule in the Kir chimera channel crystal. Polar contacts in the coarse-grained simulations corresponded to long-lived electrostatic and H-bonding interactions between the channel and PIP(2) in the atomistic simulations, enabling identification of key side chains

Исследования ледового режима на акватории Хатангского залива в море Лаптевых

The study was carried out to reveal characteristics of the ice regime of poorly explored water area of the Khatanga Bay in the South-Western part of the Laptev Sea. Actuality of the research is due to the high potential of hydrocarbon reserves in the license area «Khatangsky» of the PAO «NK «Rosneft Currently available methods of monitoring ice cover and hydrometeorological conditions throughout the year were used. The main features of the hydrological regime of the region in the ice-free period, reflected in the spatial distribution of thermohaline characteristics and sea level fluctuations, are shown. The area under investigation has specific features of the conditions for the formation of ice cover: the entire area is covered with the fast ice; the winter fresh water infl w from Khatanga and Anabar rivers results in the desalination of sea water, and this promotes formation of ice cover, which differs in crystal structure and texture from both fresh and sea ices. These factors do influence on the mechanical properties of ice, including its strength. It was found that the average and maximum values of strength of the smooth and deformed ice of the Khatanga Gulf are approximately twice as high as the similar values of the sea ice strength in the southern part of the Laptev Sea. The basic features of the spatial distribution of different types of deformations of the ice cover such as lines of ice hummocks, zones of homogeneous ice hummocking, and stamukhas had been determined.Цель исследований – выявить особенности ледового режима малоизученной акватории Хатангского залива в море Лаптевых. На основе круглогодичных исследований на стационаре «Хастыр» и весенних исследований с использованием вертолёта обнаружены новые особенности формирования ледяного покрова, связанные с притоком пресных вод и большого количества примесей, которые приводят к повышенной прочности льда. Установлено пространственное распределение различных видов деформированного льда

Molecular Biomechanics: The Molecular Basis of How Forces Regulate Cellular Function

Recent advances have led to the emergence of molecular biomechanics as an essential element of modern biology. These efforts focus on theoretical and experimental studies of the mechanics of proteins and nucleic acids, and the understanding of the molecular mechanisms of stress transmission, mechanosensing and mechanotransduction in living cells. In particular, single-molecule biomechanics studies of proteins and DNA, and mechanochemical coupling in biomolecular motors have demonstrated the critical importance of molecular mechanics as a new frontier in bioengineering and life sciences. To stimulate a more systematic study of the basic issues in molecular biomechanics, and attract a broader range of researchers to enter this emerging field, here we discuss its significance and relevance, describe the important issues to be addressed and the most critical questions to be answered, summarize both experimental and theoretical/computational challenges, and identify some short-term and long-term goals for the field. The needs to train young researchers in molecular biomechanics with a broader knowledge base, and to bridge and integrate molecular, subcellular and cellular level studies of biomechanics are articulated.National Institutes of Health (U.S.) (grant UO1HL80711-05 to GB)National Institutes of Health (U.S.) (grant R01GM076689-01)National Institutes of Health (U.S.) (grant R01AR033236-26)National Institutes of Health (U.S.) (grant R01GM087677-01A1)National Institutes of Health (U.S.) (grant R01AI44902)National Institutes of Health (U.S.) (grant R01AI38282)National Science Foundation (U.S.) (grant CMMI-0645054)National Science Foundation (U.S.) (grant CBET-0829205)National Science Foundation (U.S.) (grant CAREER-0955291

Matter Outflows from AGN: A Unifying Model

We discuss a self-consistent unified model of the matter outflows from AGNs based on a theoretical approach and involving data on AGN evolution and structure. The model includes a unified geometry, two-phase gas dynamics, radiation transfer, and absorption spectrum calculations in the UV and X-ray bands. We briefly discuss several questions about the mass sources of the flows, the covering factors, and the stability of the narrow absorption details.Comment: 6 figures, accepted for publication in Astrophysics and Space Scienc