Особенности онкологической заболеваемости населения Томской области (1990—2001 гг.)

A cancer incidence in general and in its separate nosologic forms (stomach cancer, liver cancer, cancer of lung, skin cancer, breast cancer, cervical cancer, prostate cancer, thyroid gland cancer and hemoblastosis cancer) has been studied in the population of Tomsk and Tomsk region within 1990—2001 taking into account ages and sexes. The dynamics of the cancer incidence in general and in separate forms of malignant neoplasms has been cited and the prognosis of this process up to 2007 has been done. An analysis of the main risk factors has been made.Изучена онкологическая заболеваемость в целом и ее отдельными нозологическими формами (рак желудка, рак печени, рак легкого, рак кожи, рак молочной железы, рак шейки матки, рак предстательной железы, рак щитовидной железы и гемобластозы) населения Томской области и г. Томска с учетом возраста и пола за 1990—2001 гг. Приводится динамика онкологической заболеваемости населения в целом и отдельными формами злокачественных новообразований и дан прогноз этого процесса на период до 2007 г. Дается анализ основных факторов риска

Matrix metalloproteinase system in blood serum in patients with squamous cell head and neck carcinomas

The concentrations of matrix metalloproteinases (MMP-2, -3, -9) and their tissue inhibitors (TIMP-1, -2) were studied in blood serum of 193 patients with squamous cell head and neck carcinoma (SCHNC) and in 38 healthy donors using immunoenzymatic assay. The decreased MMP-3 and TIMP-1, -2 levels were found in patients with oral cavity tumors as compared to patients with laryngeal cancer. The serum MMP-9 and TIMP-1 levels were significantly higher in head and neck cancer patients than in healthy subjects. High TIMP-1 and MMP-9 levels in blood serum of patients with SCHNC should be greatly attended for detection of their predictive and prognostic significances