Адаптационные возможности организма студентов, занимающихся лечебной физической культурой

The cardiointervalography method was used to study adaptation possibilities of students with vascular heart diseases and diseases of musculoskeletal system going to exercise therapy. The physical training organization with use exercise therapy favors the adaptation and functional reserve improvement, and the effect is more in 1st year study students with vascular heart diseases.Методом кардиоинтервалографии изучались адаптационные возможности студентов, имеющих заболевания сердечнососудистой системы и опорно-двигательного аппарата и занимающихся в группе лечебной физической культуры (ЛФК). Организация занятий по физическому воспитанию с использованием средств ЛФК способствует улучшению адаптации и функциональных резервов организма, причем в группе студентов 1-го курса с заболеваниями сердечно-сосудистой системы этот эффект выражен в большей степени

Differential Requirement for c-Jun N-terminal Kinase 1 in Lung Inflammation and Host Defense

The c-Jun N-terminal kinase (JNK) - 1 pathway has been implicated in the cellular response to stress in many tissues and models. JNK1 is known to play a role in a variety of signaling cascades, including those involved in lung disease pathogenesis. Recently, a role for JNK1 signaling in immune cell function has emerged. The goal of the present study was to determine the role of JNK1 in host defense against both bacterial and viral pneumonia, as well as the impact of JNK1 signaling on IL-17 mediated immunity. Wild type (WT) and JNK1 −/− mice were challenged with Escherichia coli, Staphylococcus aureus, or Influenza A. In addition, WT and JNK1 −/− mice and epithelial cells were stimulated with IL-17A. The impact of JNK1 deletion on pathogen clearance, inflammation, and histopathology was assessed. JNK1 was required for clearance of E. coli, inflammatory cell recruitment, and cytokine production. Interestingly, JNK1 deletion had only a small impact on the host response to S. aureus. JNK1 −/− mice had decreased Influenza A burden in viral pneumonia, yet displayed worsened morbidity. Finally, JNK1 was required for IL-17A mediated induction of inflammatory cytokines and antimicrobial peptides both in epithelial cells and the lung. These data identify JNK1 as an important signaling molecule in host defense and demonstrate a pathogen specific role in disease. Manipulation of the JNK1 pathway may represent a novel therapeutic target in pneumonia

Макро- и микроэлементы мононуклеаров крови у больных лекарственно-чувствительным и лекарственно-устойчивым туберкулезом легких

In article the results of the analysis of changes of the contents macro- and microelements (К+, Ca2+, Fe2+, Cu2+, Mn2+, Zn2+, Mg2+, Al3+) in lymphocytes and monocytes of peripheral blood in patients with infiltrative drug-sensitive and drug-resistant pulmonary tuberculosis before and on a background of realization standard antituberculosis therapy are discussedВ статье обсуждаются результаты анализа изменений содержания макро- и микроэлементов (К+, Ca2+, Fe2+, Cu2+, Mn2+, Zn2+, Mg2+, Al3+) в лимфоцитах и моноцитах периферической крови у больных c инфильтративным лекарственно-чувствительным и лекарственно-резистентным туберкулезом легких до и на фоне проведения стандартной противотуберкулезной терапии

Adaptation possibilities of students going to exercise therapy

The cardiointervalography method was used to study adaptation possibilities of students with vascular heart diseases and diseases of musculoskeletal system going to exercise therapy. The physical training organization with use exercise therapy favors the adaptation and functional reserve improvement, and the effect is more in 1st year study students with vascular heart diseases

Optogenetic regulation of transcription

Optogenetics has become widely recognized for its success in real-time control of brain neurons by utilizing non-mammalian photosensitive proteins to open or close membrane channels. Here we review a less well known type of optogenetic constructs that employs photosensitive proteins to transduce the signal to regulate gene transcription, and its possible use in medicine. One of the problems with existing gene therapies is that they could remain active indefinitely while not allowing regulated transgene production on demand. Optogenetic regulation of transcription (ORT) could potentially be used to regulate the production of a biological drug in situ, by repeatedly applying light to the tissue, and inducing expression of therapeutic transgenes when needed. Red and near infrared wavelengths, which are capable of penetration into tissues, have potential for therapeutic applications. Existing ORT systems are reviewed herein with these considerations in mind