BF₃·Et₂O‑Catalyzed Formal [3 + 2] Reaction of Aziridinofullerenes with Carbonyl Compounds

The BF₃·Et₂O-catalyzed formal [3 + 2] reaction of aziridinofullerenes with various carbonyl compounds for the easy preparation of fullerooxazolidines has been developed. Moreover, the reaction of aziridinofullerene with ethyl formate affords the simplest fullerooxazole without substituent

Phylogenetic analyses of the NoV GII.P16-GII.2 sequences based on partial RdRp and full length capsid regions (VP1).

<p>(<b>A</b>) Phylogenetic tree of a 1061 bp region of RdRp. (<b>B</b>) Phylogenetic tree of a 1629bp region ofVP1. The trees were constructed using the Neighbor-Joining analysis and the evolutionary distances were computed using the Kimura 2-parameterþG method available in MEGA v7.0. Bootstrap values (>90%) are shown as percentages derived from 1,000 samplings at the nodes of the tree. The scale bars represent the number of nucleotide substitutions per site. The norovirus strains reported in this study were marked with solid black triangles.</p

Phylogenetic analyses of the NoV GII.P16-GII.2 sequences based on partial RdRp and full length capsid regions (VP1).

<p>(<b>A</b>) Phylogenetic tree of a 1061 bp region of RdRp. (<b>B</b>) Phylogenetic tree of a 1629bp region ofVP1. The trees were constructed using the Neighbor-Joining analysis and the evolutionary distances were computed using the Kimura 2-parameterþG method available in MEGA v7.0. Bootstrap values (>90%) are shown as percentages derived from 1,000 samplings at the nodes of the tree. The scale bars represent the number of nucleotide substitutions per site. The norovirus strains reported in this study were marked with solid black triangles.</p

List of primers used in the study.

<p>List of primers used in the study.</p

Norovirus outbreaks in Jiangsu, China.

<p>(<b>A</b>) Laboratory confirmed number of monthly NoV outbreaks occurring in Jiangsu province, China from December 2016 through March 2017. (<b>B</b>) Distribution of norovirus genotypes detected in Jiangsu from December 2016 through March 2017.</p

Amino acid differences between 29 NoV strains in the RdRp region.

<p>Green regions indicate the conserved residues organized into motifs involved in enzymatic activities. Dashes indicate lack sequence information. P16-16 represents GII.P16-GII.16 strain and P16-2 represents GII.P16-GII.2 strain.</p