Binding of Vav to Grb2 through dimerization of Src homology 3 domains

The protooncogenic protein Vav has the structure of an intracellular signal transducer. It is exclusively expressed in cells of hematopoietic lineage and plays a crucial role in hematopoietic cell differentiation. Here we report that both in cell extracts and within intact mammalian cells Vav binds to Grb2 (Sem-5/ASH/Drk), an adaptor molecule which plays a key role in Ras activation. The interaction became evident from a yeast two-hybrid screen and its specificity was demonstrated by in vitro binding assays. It is mediated by an unusual protein-protein binding reaction: dimerization of specific intact Src homology 3 domains of each of the partners. Signaling during hematopoietic lineage differentiation may therefore involve the tissue-specific signal transducer Vav linking into the ubiquitous pathway involving Grb2 and ultimately Ras

Weak Decays of Stable Open-bottom Tetraquark by SU(3) Symmetry Analysis

The exotic state $X(5568)$ which was observed by D0 Collaboration is very likely to be a tetraquark state with four different valence quark flavors, though the existence was not confirmed by other collaborations. The possibility of such state still generate lots of interests in theory. In the paper, we will study the properties of the state under the SU(3) flavor symmetry. This four quark state with a heavy bottom quark and three light quarks(anti-quark) can form a $6$ or $\overline {15}$ representation. The weak decays can be dominant and should be discussed carefully while such state is stable against the strong interaction. Therefor we will study the multi-body semileptonic and nonleptonic weak decays systematically. With the help of SU(3) flavor symmetry, we can give the Hamiltonian in the hadronic level, then obtain the parameterized irreducible amplitudes and the relations of different channels. At the end of the article, we collect some Cabibbo allowed two-body and three-body weak decay channels which can be used to reconstruct $X_{b6}$ states at the branching fraction up to be $10^{-5}$.Comment: 53 pages, 2 figure

Ultrasensitive detections in atomic and molecular physics: demonstration in molecular overtone spectroscopy

We consider several highly sensitive techniques commonly used in detection of atomic and molecular absorptions. Their basic operating principles and corresponding performances are summarized and compared. We then present our latest results on the ultrasensitive detection of molecular overtone transitions to illustrate the principle and application of the cavity-enhanced frequency-modulation (FM) spectroscopy. An external cavity is used to enhance the molecular response to the light field, and an FM technique is applied for shot-noise-limited signal recovery. A perfect match between the FM sideband frequency and the cavity free spectral range makes the detection process insensitive to the laser-frequency noise relative to the cavity, and, at the same time, overcomes the cavity bandwidth limit. Working with a 1.064-µm Nd:YAG laser, we obtained sub-Doppler overtone resonances of C2HD, C2H2, and CO2 molecules. A detection sensitivity of 5 x 10^-13 of integrated absorption (1 x 10^-14/cm) over 1-s averaging time has been achieved

Microwave and hard X-ray emissions during the impulsive phase of solar flares: Nonthermal electron spectrum and time delay

On the basis of the summing-up and analysis of the observations and theories about the impulsive microwave and hard X-ray bursts, the correlations between these two kinds of emissions were investigated. It is shown that it is only possible to explain the optically-thin microwave spectrum and its relations with the hard X-ray spectrum by means of the nonthermal source model. A simple nonthermal trap model in the mildly-relativistic case can consistently explain the main characteristics of the spectrum and the relative time delays

Software-Defined Lighting.

For much of the past century, indoor lighting has been based on incandescent or gas-discharge technology. But, with LED lighting experiencing a 20x/decade increase in flux density, 10x/decade decrease in cost, and linear improvements in luminous efficiency, solid-state lighting is finally cost-competitive with the status quo. As a result, LED lighting is projected to reach over 70% market penetration by 2030. This dissertation claims that solid-state lighting’s real potential has been barely explored, that now is the time to explore it, and that new lighting platforms and applications can drive lighting far beyond its roots as an illumination technology. Scaling laws make solid-state lighting competitive with conventional lighting, but two key features make solid-state lighting an enabler for many new applications: the high switching speeds possible using LEDs and the color palettes realizable with Red-Green-Blue-White (RGBW) multi-chip assemblies. For this dissertation, we have explored the post-illumination potential of LED lighting in applications as diverse as visible light communications, indoor positioning, smart dust time synchronization, and embedded device configuration, with an eventual eye toward supporting all of them using a shared lighting infrastructure under a unified system architecture that provides software-control over lighting. To explore the space of software-defined lighting (SDL), we design a compact, flexible, and networked SDL platform to allow researchers to rapidly test new ideas. Using this platform, we demonstrate the viability of several applications, including multi-luminaire synchronized communication to a photodiode receiver, communication to mobile phone cameras, and indoor positioning using unmodified mobile phones. We show that all these applications and many other potential applications can be simultaneously supported by a single lighting infrastructure under software control.PhDElectrical EngineeringUniversity of Michigan, Horace H. Rackham School of Graduate Studieshttp://deepblue.lib.umich.edu/bitstream/2027.42/111482/1/samkuo_1.pd