The importance of studying inherited hematological disorders in ancient Anatolian populations

Before analysis of DNA from ancient remains was possible, anthropologists studied evolution and migration patterns using data obtained from population genetic studies on modern populations combined with data obtained from morphological evaluations of ancient remains. Currently, DNA analysis of ancient populations is making a valuable contribution to these efforts. Researchers that perform ancient DNA analysis prefer to study polymorphisms on the Y chromosome or mitochondrial DNA because the results are easier to statistically evaluate. To evaluate polymorphisms on diploid genomes, which are more informative, only mutations that have been extensively examined in modern populations should be chosen. The most extensively evaluated mutations are those related to prevalent inherited disorders. As such, beta-thalassemia, sickle cell anemia, FVL mutation of globin and the factor V genes are good candidates for DNA studies in ancient populations. These mutations are common in Anatolia, host to many civilizations since the Paleolithic period. This history makes Anatolia a good place for conducting research that could enhance our understanding of human evolution and migration patterns

Allele distribution data for 16 short tandem repeat loci in Bolu

Dogan Alakoc, Yesim/0000-0001-6650-6133WOS: 000281832100022Aim: To examine the short tandem repeat (STR) data of Bolu population and compare the data with previously published population studies and with the data of a neighboring province, Duzce (a former district of Bolu), which became a province after the earthquake in 1999. Materials and methods: Blood samples were taken from 175 unrelated individuals. DNA was isolated using a DNA Kit and the amplification was performed using an AmpFeSTR Identifier kit. Genotyping was carried out by an ABI Prism 310 genetic analyzer by using a reference ladder. Several parameters, such as allele frequencies, Hardy-Weinberg equilibrium, power of exclusion, power of discrimination, pairwise comparison, were calculated and correction test was used to confirm significant differences found in the comparative analysis Results: According to their power of exclusion and power of discrimination values, the most discriminating loci were D18S51 and D2S1338 whereas TPOX appears to be the least The most discriminating loci and paternity index were found to be different in Bolu and its former district, Duzce, which is an interesting result. Conclusion: The results indicate the importance of local population studies, because in regions where migration occurs and marriages between members of different ethnic groups are not socially acceptable, genetic data are affected.Abant Izzet Baysal University Scientific Research FoundationAbant Izzet Baysal UniversityThis research was supported by the Abant Izzet Baysal University Scientific Research Foundation