Synthesis, antibacterial and antioxidant activities of new 1-alkyl-4-(1-alkyl-4-oxo-1,4-dihydroquinolin-2-yl)pyridinium bromides

AKAR, ZEYNEP/0000-0001-9262-8070WOS: 000330603900033PubMed: 24077525New 1-alkyl-4-(1-alkyl-4-oxo-1,4-dihydroquinolin-2-yl)pyridinium bromides (3a k) were synthesized from 1,4'-diazaflavone [2-pyridin-4-ylquinolin-4(1H)-one] and evaluated for antibacterial and antioxidant activities. A rapid one-pot preparation of 1,4'-diazaflavone (2) was done from 2'-amino substituted chalcone (1) by intramolecular Michael addition using solvent-free microwave heating. New N,N'-dialkyl substituted (C-5-C-15) 1,4'-diazaflavonium bromides were synthesized from compound 2 with corresponding alkyl halides. Compounds 3a k were active against six bacteria (MIC: 7.8-500.0 mu g/mL). They also showed good antioxidant activities in DPPI-1* scavenging (SC50: 45-133 mu g/mL) and ferric reducing/antioxidant power (14-141 p.M TEAC) tests. the biological activities decreased as alkyl chain length increased. the reason behind the obvious negative effect of alkyl chain elongation is unclear and requires investigations about the intermolecular interactions of these pyridinium salts with bioassay components. (C) 2013 Elsevier Masson SAS. All rights reserved.Karadeniz Technical UniversityKaradeniz Technical University; Scientific and Technological Research Council of TurkeyTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [TUBiTAK-109T388]This study was supported by grants from Karadeniz Technical University and the Scientific and Technological Research Council of Turkey (TUBiTAK-109T388)

Antimicrobial Activity and Analyses of Six Geranium L. Species with Headspace SPME and Hydrodistillation

WOS: 000392643400012A solid phase microextraction (SPME) method with gas chromatography-mass spectrometry (GC-MS) was used for analyses of the volatile compounds of six Geranium species; G. asphodeloides, G. psilostemon, G. purpureum, G. pyrenaicum, G. robertianum and G. sanguineum. the results were compared with those obtained by hydrodistillation. According to the results of the study, the major compounds identified in the SPME extracts were sabinen (33.5 %) (G. asphodeloides), caryophyllene (34.1 %, 21.7 %, 11.2 %) (G. psilostemon, G. purpureum and G. robertianum), germacrene D (25.2 %) (G. pyrenaicum), and alloaromadendrene (19.8 %) (G. sanguineum) whereas hydrodistillation (HD) essential oils were rich in benzene acetaldehyde (30 %, 25.7 %) (G. asphodeloides, G. sanguineum), caryophyllene (34.3 %, 11.3 %) (G. psilostemon and G. robertianum), hexadecanoic acid (36.2 %, 15.1 %) (G. purpureum and G. pyrenaicum). the oils were screened for antimicrobial activity against 10 microorganisms and showed antibacterial and antifungal activities against Staphylococcus aureus, Bacillus cereus, Mycobacterium smegmatis, Candida albicans and Saccharomyces cerevisiae