Observability of intermittent radio sources in galaxy groups and clusters

22 pages, 24 figures. This article has been accepted for publication in Monthly Notices of the Royal Astronomical Society © 2018 The Author(s). Published by Oxford University Press on behalf of the Royal Astronomical Society. All rights reserved.We have carried out numerical hydrodynamic simulations of radio jets from active galactic nuclei using the PLUTO simulation code, with the aim of investigating the effect of different environments and intermittency of energy injection on the resulting dynamics and observable properties of the jet-inflated lobes. Initially conical jets are simulated in poor group and cluster environments. We show that the environment into which a radio jet is propagating plays a large role in the resulting morphology, dynamics and observable properties of the radio source. The same jet collimates much later in a poor group compared to a cluster, which leads to pronounced differences in radio morphology. The intermittency of the jet also affects the observable properties of the radio source, and multiple hotspots are present for multiple outburst jets in the cluster environment. We quantify the detectability of active and quiescent phases, and find this to be strongly environment-dependent. We conclude that the dynamics and observational properties of jets depend strongly on the details of energy injection and environment.Peer reviewedFinal Accepted Versio

First--principles band alignments at the Si:anatase TiO2 interface

TiO2 has been identified as a promising electron transport layer in Si solar cells. Experiments have revealed that the Si:TiO2 interface undergoes structural changes depending on how it was fabricated. However, less is understood about the sensitivity of electronic properties, such as band alignments, to these changes. Here, we present first-principles calculations of band alignments between Si and anatase TiO2, investigating different surface orientations and terminations. By calculating vacuum-level alignments, we observe a large band offset reduction of 2.5 eV for the O-terminated Si slab compared to other terminations. Furthermore, a 0.5 eV increase is found for the anatase (101) surface compared to (001). We compare the band offsets obtained through vacuum alignment with four different heterostructure models. Even though the heterostructure models contain an excess of oxygen, their offsets agree well with vacuum-level alignments using stoichiometric or H-terminated slabs, and the reduction in band offsets seen for the O-terminated Si slab is not observed. Additionally, we have investigated different exchange-correlation treatments including PBE + U, postprocessing GW corrections, and the meta-GGA rSCAN functional. We find that rSCAN provides more accurate band offsets than PBE, but further corrections are still required to achieve <0.5 eV accuracy. Overall, our study quantifies the importance of surface termination and orientation for this interface

Dynamics of relativistic radio jets in asymmetric environments

© 2021 The Author(s) Published by Oxford University Press on behalf of Royal Astronomical Society. This is the accepted manuscript version of an article which has been published in final form at https://doi.org/10.1093/mnras/stab2917We have carried out relativistic three-dimensional simulations of high-power radio sources propagating into asymmetric cluster environments. We offset the environment by 0 or 1 core radii (equal to 144 kpc), and incline the jets by 0, 15, or 45{\deg} away from the environment centre. The different environment encountered by each radio lobe provides a unique opportunity to study the effect of environment on otherwise identical jets. We find that the jets become unstable towards the end of the simulations, even with a Lorentz factor of 5; they nevertheless develop typical FR II radio morphology. The jets propagating into denser environments have consistently shorter lobe lengths and brighter hotspots, while the axial ratio of the two lobes is similar. We reproduce the recently reported observational anti-correlation between lobe length asymmetry and environment asymmetry, corroborating the notion that observed large-scale radio lobe asymmetry can be driven by differences in the underlying environment.Peer reviewedFinal Accepted Versio

PRAiSE: resolved spectral evolution in simulated radio sources

© 2021 The Authors. This is the accepted manuscript version of an article which has been published in final form at https://doi.org/10.1093/mnras/stac385We present a method for applying spatially resolved adiabatic and radiative loss processes to synthetic radio emission from hydrodynamic simulations of radio sources from active galactic nuclei (AGN). Lagrangian tracer particles, each representing an ensemble of electrons, are injected into simulations and the position, grid pressure, and time since the last strong shock are recorded. These quantities are used to track the losses of the electron packet through the radio source in a manner similar to the Radio AGN in Semi-analytic Environments (RAiSE) formalism, which uses global source properties to calculate the emissivity of each particle ex-situ. Freedom in the choice of observing parameters, including redshift, is provided through the post-processing nature of this approach. We apply this framework to simulations of jets in different environments, including asymmetric ones. We find a strong dependence of radio source properties on frequency and redshift, in good agreement with observations and previous modelling work. There is a strong evolution of radio spectra with redshift due to the more prominent inverse-Compton losses at high redshift. Radio sources in denser environments have flatter spectral indices, suggesting that spectral index asymmetry may be a useful environment tracer. We simulate intermediate Mach number jets that disrupt before reaching the tip of the lobe, and find that these retain an edge-brightened Fanaroff-Riley Type II morphology, with the most prominent emission remaining near the tip of the lobes for all environments and redshifts we study.Peer reviewe

The effect of sacubitril/valsartan compared to olmesartan on cardiovascular remodelling in subjects with essential hypertension: the results of a randomized, double-blind, active-controlled study

Aims: Progressive aortic stiffening eventually leads to left ventricular (LV) hypertrophy and heart failure if left untreated. Anti-hypertensive agents have been shown to reverse this to some extent. The effects of sacubitril/valsartan (LCZ696), a dual-action angiotensin receptor blocker (ARB), and neprilysin inhibitor, on arterial stiffness and LV remodelling have not been investigated. Methods and results: This was a randomized, multi-centre, double-blind, double-dummy, active-controlled, parallel group, study to compare the effects on cardiovascular remodelling of sacubitril/valsartan with those of olmesartan in patients with hypertension and elevated pulse pressure. Magnetic resonance imaging scans were used to assess LV mass and local aortic distensibility, at baseline and at 12 and 52 weeks after initiation of treatment. Central pulse and systolic pressure were determined using a SphymoCor® XCEL device at each time point. A total of 114 patients were included, with 57 in each treatment group. The mean age was 59.8 years, and 67.5% were male. Demographic characteristics did not vary between the two sets of patients. Left ventricular mass index decreased to a greater extent in the sacubitril/valsartan group compared to the olmesartan group from baseline to 12 weeks (−6.36 vs. −2.32 g/m2; P = 0.039) and from baseline to 52 weeks (−6.83 vs. −3.55 g/m2; P = 0.029). These differences remained significant after adjustment for systolic blood pressure (SBP) at follow-up (P = 0.036 and 0.019 at 12 and 52 weeks, respectively) and similar signals (though formally non-significant) were observed after adjusting for changes in SBP (P = 0.0612 and P = 0.0529, respectively). There were no significant differences in local distensibility changes from baseline to 12 or 52 weeks between the two groups; however, there was a larger reduction in central pulse pressure for the sacubitril/valsartan group compared to the olmesartan group (P = 0.010). Conclusion: Since LV mass change correlates with cardiovascular prognosis, the greater reductions in LV mass indicate valuable advantages of sacubitril/valsartan compared to olmesartan. The finding that LV mass index decrease might be to some extent independent of SBP suggests that the effect of the dual-acting agent may go beyond those due to its BP-lowering ability

The yeast lgl family member Sro7p is an effector of the secretory Rab GTPase Sec4p

Rab guanosine triphosphatases regulate intracellular membrane traffic by binding specific effector proteins. The yeast Rab Sec4p plays multiple roles in the polarized transport of post-Golgi vesicles to, and their subsequent fusion with, the plasma membrane, suggesting the involvement of several effectors. Yet, only one Sec4p effector has been documented to date: the exocyst protein Sec15p. The exocyst is an octameric protein complex required for tethering secretory vesicles, which is a prerequisite for membrane fusion. In this study, we describe the identification of a second Sec4p effector, Sro7p, which is a member of the lethal giant larvae tumor suppressor family. Sec4-GTP binds to Sro7p in cell extracts as well as to purified Sro7p, and the two proteins can be coimmunoprecipitated. Furthermore, we demonstrate the formation of a ternary complex of Sec4-GTP, Sro7p, and the t-SNARE Sec9p. Genetic data support our conclusion that Sro7p functions downstream of Sec4p and further imply that Sro7p and the exocyst share partially overlapping functions, possibly in SNARE regulation